The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pancreatic cancer microenvironment
Open accessAbstract
Pancreatic ductal adenocarcinoma remains an extremely aggressive malignancy that is virtually therapy‐resistant and has therefore one of the worst prognoses of all human cancers. The focus of research, which had been placed mostly on genetic and epigenetic alterations of the cancer cells themselves, has shifted gradually towards the microenvironment. The cancer microenvironment consists of various components, including fibroblasts, endothelial cells, immune cells, and endocrine cells, that interact with each other and the cancer cells in a complex fashion. This interplay has implications for pancreatic cancer cell growth, migration and invasion, angiogenesis, and immunological recognition of cancer cells. Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells to improve the outcome of this deadly disease. © 2007 Wiley‐Liss, Inc.
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Maitra, A., Adsay, N. V., Argani, P., Iacobuzio-Donahue, C., De Marzo, A., Cameron, J. L., Yeo, C. J., & Hruban, R. H. (2003) · Modern Pathology · doi:10.1097/01.mp.0000086072.56290.fb · Cited by 429
Cited by
Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.22 · Cited by 1,982
Self-citationTherapeutic developments in pancreatic cancer: current and future perspectives
Neoptolemos, J. P., Kleeff, J., Michl, P., Costello, E., Greenhalf, W., & Palmer, D. H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0005-x · Cited by 1,170
Self-citationBarry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
Pylayeva-Gupta, Y., Lee, K. E., Hajdu, C. H., Miller, G., & Bar-Sagi, D. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.024 · Cited by 721
“The progression of pancreatic neoplasia is accompanied by cellular and molecular alterations in both the parenchymal and stromal compartments of the pancreas (Kleeff et al., 2007).”
BackgroundInfluentialLongati, P., Jia, X., Eimer, J., Wagman, A., Witt, M.-R., Rehnmark, S., Verbeke, C., Toftgård, R., Löhr, M., & Heuchel, R. L. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-95 · Cited by 394
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Metadata
- Authors
- Kleeff, J., Beckhove, P., Esposito, I., Herzig, S., Huber, P. E., Löhr, J. M., & Friess, H.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2007-05-29
- Volume
- 121
- Issue
- 4
- Pages
- 699-705
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2040018919
- Cited by
- 225
- References
- 1
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kleeff, J., Beckhove, P., Esposito, I., Herzig, S., Huber, P. E., Löhr, J. M., & Friess, H. (2007). Pancreatic cancer microenvironment. International Journal of Cancer. https://doi.org/10.1002/ijc.22871
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