The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
Open accessAbstract
Merkel cell polyomavirus (MCV) is a newly‐discovered human tumor virus found in ∼80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown. We developed a MCV virus‐like particle (VLP) enzyme‐linked immunoassay (EIA) that does not cross‐react with human BK or murine polyomaviruses. Peptide mapping of the MCV VP1 gene and immunoblotting with denatured MCV VLP are less sensitive than the MCV EIA in detecting MCV antibodies suggesting antibody reactivity in this assay primarily targets conformational but not linear epitopes. Among MCC patients, all 21 (100%) patients tested with MCV‐positive tumors had high serum MCV IgG but not high MCV IgM levels. Only 3 of 6 (50%) MCC patients with MCV‐negative tumors were positive for MCV antibodies. Sera from most adults, including 107 of 166 (64%) blood donors, 63 of 100 (63%) commercial donors and 37 of 50 (74%) systemic lupus erythematosus patients, show evidence for prior MCV exposure. Age‐specific MCV prevalence was determined by examining a cross‐sectional distribution of 150 Langerhans cell histiocytosis (an unrelated neoplasm) patient sera. MCV prevalence increases from 50% among children age 15 years or younger to 80% among persons older than 50 years. We did not find evidence for vertical transmission among infants. Although past exposure to MCV is common among all adult groups, MCC patients have a markedly elevated MCV IgG response compared with control patients. Our study demonstrates that MCV is a widespread but previously unrecognized human infection. © 2009 UICC
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Cites
Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
Feng, H., Shuda, M., Chang, Y., & Moore, P. S. (2008) · Science · doi:10.1126/science.1152586 · Cited by 3,208
Self-citationA Controlled Trial of a Human Papillomavirus Type 16 Vaccine
Koutsky, L. A., Ault, K. A., Wheeler, C. M., Brown, D. R., Barr, E., Alvarez, F. B., Chiacchierini, L. M., & Jansen, K. U. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020586 · Cited by 1,602
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
Shuda, M., Feng, H., Kwun, H. J., Rosen, S. T., Gjoerup, O., Moore, P. S., & Chang, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806526105 · Cited by 728
Self-citationIdentification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections
Gaynor, A. M., Nissen, M. D., Whiley, D. M., Mackay, I. M., Lambert, S. B., Wu, G., Brennan, D. C., Storch, G. A., Sloots, T. P., & Wang, D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030064 · Cited by 707
Identification of a Third Human Polyomavirus
Allander, T., Andreasson, K., Gupta, S., Bjerkner, A., Bogdanovic, G., Persson, M. A. A., Dalianis, T., Ramqvist, T., & Andersson, B. (2007) · Journal of Virology · doi:10.1128/jvi.00028-07 · Cited by 659
Merkel cell carcinoma and HIV infection
Engels, E. A., Frisch, M., Goedert, J. J., Biggar, R. J., & Miller, R. W. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07668-7 · Cited by 550
Efficient Intracellular Assembly of Papillomaviral Vectors
Buck, C. B., Pastrana, D. V., Lowy, D. R., & Schiller, J. T. (2004) · Journal of Virology · doi:10.1128/jvi.78.2.751-757.2004 · Cited by 489
Self-citationShuda, M., Arora, R., Kwun, H. J., Feng, H., Sarid, R., Fernández‐Figueras, M., Tolstov, Y., Gjoerup, O., Mansukhani, M. M., Swerdlow, S. H., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24510 · Cited by 373
Self-citationKassem, A., Schöpflin, A., Diaz, C., Weyers, W., Stickeler, E., Werner, M., & zur Hausen, A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0949 · Cited by 369
Pastrana, D. V., Buck, C. B., Pang, Y.-Y. S., Thompson, C. D., Castle, P. E., FitzGerald, P. C., Krüger Kjaer, S., Lowy, D. R., & Schiller, J. T. (2004) · Virology · doi:10.1016/j.virol.2003.12.027 · Cited by 357
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Cited by
Why do viruses cause cancer? Highlights of the first century of human tumour virology
Moore, P. S., & Chang, Y. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2961 · Cited by 745
Self-citationMerkel cell carcinoma: Current US incidence and projected increases based on changing demographics
Paulson, K. G., Park, S. Y., Vandeven, N. A., Lachance, K., Thomas, H., Chapuis, A. G., Harms, K. L., Thompson, J. A., Bhatia, S., Stang, A., et al. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.10.028 · Cited by 528
Shuda, M., Arora, R., Kwun, H. J., Feng, H., Sarid, R., Fernández‐Figueras, M., Tolstov, Y., Gjoerup, O., Mansukhani, M. M., Swerdlow, S. H., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24510 · Cited by 373
Self-citationMucin biopolymers as broad-spectrum antiviral agents
Lieleg, O., Lieleg, C., Bloom, J., Buck, C. B., & Ribbeck, K. (2012) · Biomacromolecules · doi:10.1021/bm3001292 · Cited by 167
Self-citationLi, J., Wang, X., Diaz, J., Tsang, S. H., Buck, C. B., & You, J. (2013) · Journal of Virology · doi:10.1128/jvi.01216-13 · Cited by 128
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Metadata
- Authors
- Tolstov, Y. L., Pastrana, D. V., Feng, H., Becker, J. C., Jenkins, F. J., Moschos, S., Chang, Y., Buck, C. B., & Moore, P. S.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2009-07-14
- Volume
- 125
- Issue
- 6
- Pages
- 1250-1256
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2141975379
- Cited by
- 339
- References
- 22
- FWCI
- 14.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tolstov, Y. L., Pastrana, D. V., Feng, H., Becker, J. C., Jenkins, F. J., Moschos, S., Chang, Y., Buck, C. B., & Moore, P. S. (2009). Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. International Journal of Cancer. https://doi.org/10.1002/ijc.24509
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