The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
MicroRNA‐30a inhibits epithelial‐to‐mesenchymal transition by targeting Snai1 and is downregulated in non‐small cell lung cancer
Open accessAbstract
MicroRNAs (miRNAs) are small non‐coding RNAs which regulate gene expression by base‐pairing to the 3′‐UTR of the target mRNA. Recently, miRNAs have been shown to regulate cancer metastasis, however, central molecular mechanisms of this ability still need to be investigated. Epithelial to mesenchymal transition (EMT), which is characterized especially by repression of E‐cadherin expression and increased cell motility, is an essential component of cancer metastasis and progression. In the present study, we found that Snai1, a known transcriptional repressor of E‐cadherin and modulator of EMT, is post‐transcriptionally targeted by miRNA‐30a in non‐small cell lung cancer (NSCLC). Consistent with this, microRNA‐30a expression was found inversely proportional to the invasive potential of various NSCLC cell lines, correlating positively with E‐cadherin (epithelial marker) and negatively with N‐cadherin (mesenchymal marker) expression. Forced re‐introduction of miR‐30a significantly altered cell morphology, in vitro invasion and migration of invasive cell lines, this being paralleled by a downregulation of Snai1 and upregulation of E‐cadherin expression. Using a chicken embryonic metastasis assay, we found that miR‐30a suppresses in vivo distant metastasis to the lungs and liver. Finally, we screened the expression of miR‐30a in 64 consecutively resected NSCLC patients and found that, in 81% of the patients, expression of miR‐30a was downregulated significantly (p < 0.0001) in tumors compared to corresponding normal tissues. These results suggest that miR‐30a targets Snai1, inhibits invasion and metastasis, and is downregulated in NSCLC.
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The Versatile Role of microRNA-30a in Human Cancer
Wang, C., Yang, X., Chen, Y., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471111 · Cited by 3,409
Anoikis molecular pathways and its role in cancer progression
Paoli, P., Giannoni, E., & Chiarugi, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.026 · Cited by 1,160
Epithelial-mesenchymal transitions: insights from development
Lim, J., & Thiery, J. P. (2012) · Development · doi:10.1242/dev.071209 · Cited by 661
Lung cancer epigenetics: From knowledge to applications
Duruisseaux, M., & Esteller, M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.005 · Cited by 283
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Metadata
- Authors
- Kumarswamy, R., Mudduluru, G., Ceppi, P., Muppala, S., Kozlowski, M., Niklinski, J., Papotti, M., & Allgayer, H.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2011-08-08
- Volume
- 130
- Issue
- 9
- Pages
- 2044-2053
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1966347977
- Cited by
- 298
- References
- 38
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kumarswamy, R., Mudduluru, G., Ceppi, P., Muppala, S., Kozlowski, M., Niklinski, J., Papotti, M., & Allgayer, H. (2012). MicroRNA‐30a inhibits epithelial‐to‐mesenchymal transition by targeting Snai1 and is downregulated in non‐small cell lung cancer. International Journal of Cancer. https://doi.org/10.1002/ijc.26218
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