The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A continuous tumor‐cell line from a human lung carcinoma with properties of type II alveolar epithelial cells
Abstract
The A549 tumor‐cell line, initiated from a human alveolar cell carcinoma, has been continuously propagated in vitro for more than 3 years (more than 1,000 cell generations). These cells have a human karyotype and appear to have been derived from a single parent cell. All A549 cells examined by electron microscopy at both early and late passage levels contain multilamellar cytoplasmic inclusion bodies typical of those found in type II alveolar epithelial cells of the lung. At early and late passage levels, the cells synthesize lecithin with a high percentage of disaturated fatty acids utilizing the cytidine diphosphocholine pathway; such a pattern of phospholipid synthesis is expected for cells believed to be responsible for pulmonary surfactant synthesis. The A549 cell line should permit in vitro analysis of human surfactant synthesis and secretion and possibly provide a source of human surfactant for therapeutic intervention in pulmonary disease states characterized by surfactant deficiency.
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Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Banded Marker Chromosomes as Indicators of Intraspecies Cellular Contamination
Nelson-Rees, W. A., Flandermeyer, R. R., & Hawthorne, P. K. (1974) · Science · doi:10.1126/science.184.4141.1093 · Cited by 210
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Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1715 · Cited by 471
Stretch induces cytokine release by alveolar epithelial cells in vitro
Vlahakis, N. E., Schroeder, M. A., Limper, A. H., & Hubmayr, R. D. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.1.l167 · Cited by 389
Metadata
- Authors
- Lieber, M., Todaro, G., Smith, B., Szakal, A., & Nelson‐Rees, W.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1976-01-15
- Volume
- 17
- Issue
- 1
- Pages
- 62-70
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2059944938
- Cited by
- 1,283
- References
- 2
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lieber, M., Todaro, G., Smith, B., Szakal, A., & Nelson‐Rees, W. (1976). A continuous tumor‐cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. International Journal of Cancer. https://doi.org/10.1002/ijc.2910170110
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