The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas
Abstract
The frequency of Ki‐ras gene mutations was studied in 100 paraffin‐embedded sections obtained from 63 pancreatic adenocarcinomas by in vitro amplification of target sequences via polymerase chain reaction (PCR) and selective oligonucleotide hybridization. Forty‐seven (75%) of the tumors contained a Ki‐ras mutation at codon 12. No predominant amino acid substitution or nucleotide transition at this codon was observed. Two carcinomas exhibited 2 distinct Ki‐ras mutations. No particular correlation could be established between the incidence of Ki‐ras mutation and clinical parameters (sex, age, survival), tumor grade or tumor stage.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
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Cited by
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Genetic, Immunohistochemical, and Clinical Features of Medullary Carcinoma of the Pancreas
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Ras gene mutation and amplification in human nonmelanoma skin cancers
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Metadata
- Authors
- Grünewald, K., Lyons, J., Fröhlich, A., Feichtinger, H., Weger, R. A., Schwab, G., Janssen, J. W. G., & Bartram, C. R.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1989-06-15
- Volume
- 43
- Issue
- 6
- Pages
- 1037-1041
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2050760539
- Cited by
- 290
- References
- 14
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas. https://app.cochat.ai/papers/10.1002/ijc.2910430614
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- Grünewald, K., Lyons, J., Fröhlich, A., Feichtinger, H., Weger, R. A., Schwab, G., Janssen, J. W. G., & Bartram, C. R. (1989). High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas. International Journal of Cancer. https://doi.org/10.1002/ijc.2910430614
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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