The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
p53 Mutations in sporadic adrenocortical tumors
Abstract
Non-familial human adrenocortical adenomas and carcinomas were screened for mutations in exons 5-8 of the p53 tumor suppressor gene by single-strand-conformation-polymorphism (SSCP) analysis, followed by direct sequencing of PCR-amplified DNA. Point mutations in codons 12, 13 and 61 in H-ras, K-ras and N-ras proto-oncogenes were similarly assessed by direct DNA sequencing. Three out of 15 primary adrenocortical carcinomas (20%) contained a mis-sense point mutation in the conserved regions (exons 5 and 8) of the p53 gene. Mutations were located in codon 157 (GTC-->TTC; Val-->Phe), codon 163 (TAC-->AAC; Tyr-->Asn), and codon 273 (CGT-->TGT; Arg-->Cys). The mutation in codon 157 was detected in the primary tumor as well as in brain and lymph-node metastases. Among 18 adrenocortical adenomas, there was only a single non-miscoding mutation in codon 295 (CCT-->CCC; Pro-->Pro). These data suggest that mutational inactivation of the p53 gene occurs in a minority (20%) of sporadic adrenocortical carcinomas and that these mutations constitute a late event in the multi-step process of malignant transformation. No ras mutations were detected in any of these tumors, suggesting that these genes are not involved in the development of tumors originating from the adrenal cortex.
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“High-grade ACCs are enriched for mutations of TP53 (14, 140–142) and/or CTNNB1 (143–149), and these mutations tend to be mutually exclusive (reviewed in Ref. 150).”
From Adrenocortical carcinoma (2014) · cites this paper as [140]
In the citing paper
“TP53 located on 17p13 is the most commonly mutated gene in ACC, present in at least one-third of ACCs (140, 142, 202).”
From Adrenocortical carcinoma (2014) · cites this paper as [140]
Citations
Cites
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
ras oncogenes in human cancer: a review.
Bos, J. L. (1989) · PubMed · Cited by 5,061
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765
Orita, M., Suzuki, Y., Sekiya, T., & Hayashi, K. (1989) · Genomics · doi:10.1016/0888-7543(89)90129-8 · Cited by 3,419
Mutations in the p53 gene occur in diverse human tumour types
Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hosteller, R., Cleary, K. R., Signer, S. H., Davidson, N. E., Baylin, S., Devilee, P., et al. (1989) · Nature · doi:10.1038/342705a0 · Cited by 2,730
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome
Srivastava, S. K., Zou, Z., Pirollo, K. F., Blattner, W. A., & Chang, E. H. (1990) · Nature · doi:10.1038/348747a0 · Cited by 1,210
Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.
Weinberg, R. A. (1989) · PubMed · Cited by 952
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920
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Molecular and Genetics Perspectives on Primary Adrenocortical Hyperfunction Disorders
Kim, S., Chaudhary, P. K., & Kim, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111341 · Cited by 4
Elevated levels of p53 protein in adrenocortical carcinomas from Costa Rica
Hildesheim, A., Herrero, R., Johnson, J., Bratti, C., Bhatia, K. G., MAGRATH, I. T., & Fraumeni, J. F. (1995) · European Journal of Cancer · doi:10.1016/0959-8049(94)00465-h · Cited by 3
Molecular genetics of adrenal cortical tumors
Kjellman, M., Roshani, L., Bäckdahl, M., & Larsson, C. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199902000-00012 · Cited by 3
Bragayrac, L. A. N., & Schwaab, T. (2019) · Springer eBooks · doi:10.1007/978-3-319-42603-7_41-1 · Cited by 2
Adrenocortical Tumors and Oncogenes
Reincke, M. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-101-5_16 · Cited by 2
Coexpression of p53 and tissue transglutaminase genes in human normal and pathologic adrenal tissues
Adleff, V., Rácz, K., Szende, B., Tóth, M., Moldvay, J., Varga, I., Bezzegh, A., Szegedi, Z., & Gláz, E. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00004-1 · Cited by 2
Cytogenetic Abnormalities Associated with Endocrine Neoplasia
Grebe, S. K. G., Eberhardt, N. L., & Jenkins, R. B. (1997) · Humana Press eBooks · doi:10.1007/978-1-4612-3952-9_14 · Cited by 2
Cellular and Molecular Pathology of Adrenocortical Carcinoma
Else, T. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_9 · Cited by 1
Li–Fraumeni syndrome: a role for surgical pathologists?
Dickson, B. C. (2012) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2012.01.003 · Cited by 1
Loss of heterozygosity analysis to diagnose adrenal cortical carcinoma
MANSUKHANI, M. M., & Greenebaum, E. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990825)87:4 · Cited by 1
Analysis of Clinical Features of Korean Patients with Adrenocortical Carcinoma
Yoon, C. H., Jung, T. S., Jung, H. S., Lee, E. Y., Bae, S. J., Kim, J. Y., Chung, J. H., Min, Y., Lee, M., Lee, M., et al. (2006) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2006.21.1.47 · Cited by 1
Desai, M., Bathini, P., Bee, H., & Kancha, R. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-1802-3_19 · Cited by 1
Molekulare Grundlagen von Erkrankungen der Nebenniere
Reincke, M., Peter, M., Neumann, H. P. H., Bender, B., & Gimm, O. (2001) · Springer eBooks · doi:10.1007/978-3-642-56858-9_10
Regulation and Function of GATA Transcription Factors in Adrenocortical Tumors and Granulosa Cells
Parviainen, H. (2011) · Työväentutkimus Vuosikirja
GATA TRANSCRIPTION FACTORS IN THE DEVELOPMENT AND TUMORS OF THE ADRENAL CORTEX
Kiiveri, S. (2004) · Työväentutkimus Vuosikirja
Laforga, J. B., & Aranda, I. (1999) · Diagnostic Cytopathology · doi:10.1002/(sici)1097-0339(199912)21:6
Importância da via do mevalonato nas neoplasias do córtex adrenal
Valassi, H. P. L. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2011.tde-18022011-122810
Benign and Malignant Diseases of the Adrenal Cortex
McNicol, A. M. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-1707-2_21
The adrenal glands and tumors of extra-adrenal paraganglia
McNicol, A. M., & Lack, E. E. (2015) · Cambridge University Press eBooks · doi:10.1017/9781139137201.045
Zambetti, G. P., & Ribeiro, R. C. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_12
Local Control of Steroid Hormone Biosynthesis
Hofland, J. (2012) · EUR Research Repository (Erasmus University Rotterdam)
Neuroendocrine TumorsPractice Guidelines in Oncology
Shah, M. H., Shibata, S., Strosberg, J., Vauthey, J., White, R. R., Yao, J. C., Freedman-Cass, D. A., Dwyer, M. A., Kulke, M. H., Benson, A. B., et al. (2012)
Genetics of Adrenocortical Cancers
Assié, G., & Bertherat, J. Y. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_4
21and Malignant Diseases of the Adrenal Cortex
Couvelard, A. (2010)
McNicol, A. M. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-396-1_8
El antimilitarismo en el movimiento antiguerra
Barranco, C. P. (2003) · Africa América Latina, cuadernos: Revista de análisis sur-norte para una cooperación solidaria
Higham, C. E., Coen, J. J., Boland, G. W., & Trainer, P. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-560-2_4
Jouinot, A., Libé, R., & Bertherat, J. Y. (2022) · doi:10.1093/med/9780198870197.003.0096
Bragayrac, L. A. N., & Schwaab, T. (2019) · Springer eBooks · doi:10.1007/978-3-319-42623-5_41
Adrenocortical Carcinoma: Genetics and Molecular Markers
Jouinot, A., & Assié, G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64281-2
Grossman, R. F., & Clark, O. H. (1994) · World Journal of Surgery · doi:10.1007/bf00353736
New diagnostic and therapeutic approaches in adrenocortical cancer.
Khan, T. S. (2004) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Adrenocortical carcinoma: Genetics and molecular markers
Šojat, A. S., Jouinot, A., & Assié, G. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00277-6
Metadata
- Authors
- Ohgaki, H., Kleihues, P., & Heitz, P. U.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Kleihues, P.
- ORCID
- Ohgaki, H.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1993-05-28
- Volume
- 54
- Issue
- 3
- Pages
- 408-410
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2033246829
- Cited by
- 139
- References
- 29
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 8
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- TP53 mutation, adrenocortical carcinoma, adrenal adenoma, adrenal cortex neoplasms, H-Ras, KRAS, NRAS, Ras proto-oncogene, metastatic cancer, malignant transformation, tumor suppressor inactivation
- MeSH terms
- Adenoma, Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Base Sequence, Carcinoma, Chromosomes, Human, Pair 17, Codon, DNA, Single-Stranded, Exons, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Genes, ras, Genes, p53, Point Mutation
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