Cited by 139Adrenal and Paraganglionic TumorsCancer-related Molecular PathwaysChromatin Remodeling and Cancer

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p53 Mutations in sporadic adrenocortical tumors

Ohgaki, H., Kleihues, P., Heitz, P. U.·1993·International Journal of Cancer

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Abstract

Non-familial human adrenocortical adenomas and carcinomas were screened for mutations in exons 5-8 of the p53 tumor suppressor gene by single-strand-conformation-polymorphism (SSCP) analysis, followed by direct sequencing of PCR-amplified DNA. Point mutations in codons 12, 13 and 61 in H-ras, K-ras and N-ras proto-oncogenes were similarly assessed by direct DNA sequencing. Three out of 15 primary adrenocortical carcinomas (20%) contained a mis-sense point mutation in the conserved regions (exons 5 and 8) of the p53 gene. Mutations were located in codon 157 (GTC-->TTC; Val-->Phe), codon 163 (TAC-->AAC; Tyr-->Asn), and codon 273 (CGT-->TGT; Arg-->Cys). The mutation in codon 157 was detected in the primary tumor as well as in brain and lymph-node metastases. Among 18 adrenocortical adenomas, there was only a single non-miscoding mutation in codon 295 (CCT-->CCC; Pro-->Pro). These data suggest that mutational inactivation of the p53 gene occurs in a minority (20%) of sporadic adrenocortical carcinomas and that these mutations constitute a late event in the multi-step process of malignant transformation. No ras mutations were detected in any of these tumors, suggesting that these genes are not involved in the development of tumors originating from the adrenal cortex.

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Authors: Ohgaki, H., Kleihues, P., & Heitz, P. U.
Affiliations: University Hospital Zurich (CH)
Corresponding author: Kleihues, P.
ORCID: Ohgaki, H.
Venue: International Journal of Cancer
Publisher: Wiley
Published: 1993-05-28
Volume: 54
Issue: 3
Pages: 408-410
ISSN: 0020-7136 (ISSN-L)
1097-0215
DOI: 10.1002/ijc.2910540310
OpenAlex: W2033246829
Cited by: 139
References: 29
Citations by year: 2026: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 8
FWCI: 5.86
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4798 d)
Locations: International Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: TP53 mutation, adrenocortical carcinoma, adrenal adenoma, adrenal cortex neoplasms, H-Ras, KRAS, NRAS, Ras proto-oncogene, metastatic cancer, malignant transformation, tumor suppressor inactivation
MeSH terms: Adenoma, Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Base Sequence, Carcinoma, Chromosomes, Human, Pair 17, Codon, DNA, Single-Stranded, Exons, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Genes, ras, Genes, p53, Point Mutation

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p53 Mutations in sporadic adrenocortical tumors

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