Cited by 170Immune Cell Function and InteractionImmunotherapy and Immune Responsesinterferon and immune responses

A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity

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Diefenbach, Andreas, Hsia, Jennifer K., Hsiung, Ming‐Yu B., Raulet, David H.·2003·European Journal of Immunology

Abstract

NK cells are involved in the immune response against viral and microbial infections and tumors. In contrast to B and T cells, NK cells employ various modes of immune recognition. An important mode of immune recognition employed by NK cells is "induced self recognition" exemplified by the NKG2D receptor–ligand system. The NKG2D immunoreceptor, expressed by NK cells, and by activated CD8+ T cells and macrophages, recognizes one of several cell surface ligands that are distantly related to MHC class I molecules (i.e. H60 and Rae1 proteins in mice, and MHC class I chain‐related proteins and UL‐16‐binding proteins in humans). These ligands are not expressed abundantly by most normal cells but are up‐regulated on cells exposed to various forms of cellular insults.Here we report the cloning of another ligand for NKG2D; transcripts of this ligand are found in a wide variety of tissues and in various tumor cells. Cross‐linking of NKG2D with the novel ligand potently activated NK cells and macrophages. Tumor cells ectopically expressing the molecule were efficiently rejected by naive mice, and induced strong protective immunity to the parental, ligand‐negative tumor cells.

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Authors
Diefenbach, A., Hsia, J. K., Hsiung, M. B., & Raulet, D. H.
Affiliations
University of California, Berkeley (US)
Corresponding author
Raulet, David H.
Venue
European Journal of Immunology
Publisher
Wiley
Published
2003-01-27
Volume
33
Issue
2
Pages
381-391
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
OpenAlex
W2090487140
Cited by
170
References
41
Citations by year
2026: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 10
FWCI
4.65
Type
journal article
Language
en
Open access
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
NKG2D, NKG2D ligands, natural killer cells, macrophages, antitumor immunity, Rae1, tumor rejection, NK cell activation
MeSH terms
Amino Acid Sequence, Animals, Carrier Proteins, Cloning, Molecular, Cytotoxicity, Immunologic, Interferons, Killer Cells, Natural, Ligands, Macrophages, Membrane Proteins, Molecular Sequence Data, Neoplasm Transplantation, Neoplasms, Organ Specificity, Receptors, Immunologic, Recombinant Fusion Proteins, RNA, Messenger, Transfection, Transplantation, Isogeneic, Tumor Cells, Cultured, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens, Lymphoma, T-Cell, Sequence Alignment, Genes, RAG-1, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Mice, Knockout, Mice, Receptors, Natural Killer Cell, NK Cell Lectin-Like Receptor Subfamily K

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