A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity
Open accessAbstract
NK cells are involved in the immune response against viral and microbial infections and tumors. In contrast to B and T cells, NK cells employ various modes of immune recognition. An important mode of immune recognition employed by NK cells is "induced self recognition" exemplified by the NKG2D receptor–ligand system. The NKG2D immunoreceptor, expressed by NK cells, and by activated CD8+ T cells and macrophages, recognizes one of several cell surface ligands that are distantly related to MHC class I molecules (i.e. H60 and Rae1 proteins in mice, and MHC class I chain‐related proteins and UL‐16‐binding proteins in humans). These ligands are not expressed abundantly by most normal cells but are up‐regulated on cells exposed to various forms of cellular insults.Here we report the cloning of another ligand for NKG2D; transcripts of this ligand are found in a wide variety of tissues and in various tumor cells. Cross‐linking of NKG2D with the novel ligand potently activated NK cells and macrophages. Tumor cells ectopically expressing the molecule were efficiently rejected by naive mice, and induced strong protective immunity to the parental, ligand‐negative tumor cells.
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Transplanted tumor cells expressing NKG2D ligands are rejected by NK cells and, in some cases, T cells.
“Previous studies from our laboratory demonstrated that transplanted tumor cells expressing NKG2D ligands are rejected by NK cells and, in some cases, T cells (Diefenbach et al., 2000, 2001, 2003)”
From p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells (2013) · cites this paper as Diefenbach et al., 2003
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617 · see citing works
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., & Spies, T. A. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 3,000 · see citing works
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902 · see citing works
In search of the ‘missing self’: MHC molecules and NK cell recognition
Ljunggren, H.-G., & Kärre, K. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90097-s · Cited by 2,687 · see citing works
Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267 · see citing works
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918 · see citing works
Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis
Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Biassoni, R., & Moretta, L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.197 · Cited by 1,773 · see citing works
[31] PHD: Predicting one-dimensional protein structure by profile-based neural networks
Rost, B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66033-9 · Cited by 1,282 · see citing works
Cosman, D. J., Müllberg, J., Sutherland, C. L., Chin, W. A., Armitage, R. J., Fanslow, W. C., Kubin, M. Z., & Chalupny, N. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00095-4 · Cited by 1,228 · see citing works
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142 · see citing works
Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
Diefenbach, A., Jensen, E. R., Jamieson, A. M., & Raulet, D. H. (2001) · Nature · doi:10.1038/35093109 · Cited by 1,083 · see citing works
Self-citationBroad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
Groh, V., Rhinehart, R. L., Secrist, H., Bauer, S., Grabstein, K. H., & Spies, T. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6879 · Cited by 1,026 · see citing works
Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells
Groh, V., Rhinehart, R. L., Randolph‐Habecker, J., Topp, M. S., Riddell, S. R., & Spies, T. A. (2001) · Nature Immunology · doi:10.1038/85321 · Cited by 949 · see citing works
Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N., & Raulet, D. H. (2000) · Nature Immunology · doi:10.1038/77793 · Cited by 878 · see citing works
Self-citationRole of hemolysin for the intracellular growth of Listeria monocytogenes.
Portnoy, P. S., Jacks, P. S., & Hinrichs, D. J. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1459 · Cited by 872 · see citing works
Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice
Cerwenka, A., Bakker, A. B. H., McClanahan, T., Wagner, J., Wu, J., Phillips, J. H., & Lanier, L. L. (2000) · Immunity · doi:10.1016/s1074-7613(00)80222-8 · Cited by 695 · see citing works
Functional annotation of a full-length mouse cDNA collection
Kawai, J., Shinagawa, A., Shibata, K., Yoshino, M., Itoh, M., Ishii, Y., Arakawa, T., Hara, A., Fukunishi, Y., Konno, H., et al. (2001) · Nature · doi:10.1038/35055500 · Cited by 665 · see citing works
The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing
Jamieson, A. M., Diefenbach, A., McMahon, C. W., Xiong, N., Carlyle, J. R., & Raulet, D. H. (2002) · Immunity · doi:10.1016/s1074-7613(02)00333-3 · Cited by 647 · see citing works
Self-citationRegulation of the Natural Killer Cell Receptor Repertoire
Raulet, D. H., Vance, R. E., & McMahon, C. W. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.291 · Cited by 520 · see citing works
Self-citationDiefenbach, A., Tomasello, E., Lucas, M., Jamieson, A. M., Hsia, J. K., Vivier, É., & Raulet, D. H. (2002) · Nature Immunology · doi:10.1038/ni858 · Cited by 453 · see citing works
Self-citationNKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
Gilfillan, S., Ho, E. L., Cella, M., Yokoyama, W. M., & Colonna, M. (2002) · Nature Immunology · doi:10.1038/ni857 · Cited by 437 · see citing works
Diefenbach, A., Schindler, H., Donhauser, N., Lorenz, E., Laskay, T., MacMicking, J. D., Röllinghoff, M., Gresser, I., & Bogdan, C. (1998) · Immunity · doi:10.1016/s1074-7613(00)80460-4 · Cited by 368 · see citing works
Self-citationCarayannopoulos, L. N., Naidenko, O. V., Fremont, D. H., & Yokoyama, W. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4079 · Cited by 274 · see citing works
Tieng, V., Bouguénec, C. L., du Merle, L., Bertheau, P., Desreumaux, P., Janin, A., Charron, D. J., & Toubert, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032668099 · Cited by 235 · see citing works
The Molecular and Functional Characterization of a Dominant Minor H Antigen, H60
Malarkannan, S., Shih, P. P., Eden, P. A., Horng, T., Zuberi, A. R., Christianson, G. J., Roopenian, D. C., & Shastri, N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3501 · Cited by 233 · see citing works
The innate immune response to tumors and its role in the induction of T‐cell immunity
Diefenbach, A., & Raulet, D. H. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18802.x · Cited by 229 · see citing works
Self-citationStrategies for target cell recognition by natural killer cells
Diefenbach, A., & Raulet, D. H. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1810114.x · Cited by 210 · see citing works
Self-citationMCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo
Krmpotić, A., Busch, D. H., Bubić, I., Gebhardt, F. E., Hengel, H., Hasan, M., Scalzo, A. A., Koszinowski, U. H., & Jonjić, S. (2002) · Nature Immunology · doi:10.1038/ni799 · Cited by 208 · see citing works
Verkaik, N. S., Esveldt, R. E., van Heemst, D., Brüggenwirth, H. T., Hoeijmakers, J. H. J., Zdzienicka, M. Z., & van Gent, D. C. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200203)32:3 · Cited by 189 · see citing works
Hayakawa, Y., Kelly, J. M., Westwood, J. A., Darcy, P. K., Diefenbach, A., Raulet, D. H., & Smyth, M. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5377 · Cited by 185 · see citing works
Self-citationA Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2–q25.3
Radosavljevic, M., Cuillerier, B., Wilson, M. J., Clément, O., Wicker, S., Gilfillan, S., Beck, S., Trowsdale, J., & Bahram, S. (2002) · Genomics · doi:10.1006/geno.2001.6673 · Cited by 160 · see citing works
Vance, R. E., Tanamachi, D. M., Hanke, T., & Raulet, D. H. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271222 · Cited by 116 · see citing works
Self-citationMolecular Competition for NKG2D
O’Callaghan, C. A., Cerwenka, A., Willcox, B. E., Lanier, L. L., & Björkman, P. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00187-x · Cited by 115 · see citing works
Nomura, M., Zou, Z., Joh, T., Takihara, Y., Matsuda, Y., & Shimada, K. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021517 · Cited by 99 · see citing works
Zou, Z., Nomura, M., Takihara, Y., Yasunaga, T., & 島田, 和. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021242 · Cited by 90 · see citing works
Onda, H., Ohkubo, S., Shintani, Y., Ogi, K., Kikuchi, K., Tanaka, H., Yamamoto, K., Tsuji, I., Ishibashi, Y., Yamada, T., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5149 · Cited by 30 · see citing works
Tanamachi, D. M., Hanke, T., Takizawa, H., Jamieson, A. M., & Raulet, D. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.307 · Cited by 29 · see citing works
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Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
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The Immunobiology of Cancer Immunosurveillance and Immunoediting
Dunn, G. P., Old, L. J., & Schreiber, R. D. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.017 · Cited by 3,036 · see citing works
Lanier, L. L. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,765 · see citing works
Roles of the NKG2D immunoreceptor and its ligands
Raulet, D. H. (2003) · Nature reviews. Immunology · doi:10.1038/nri1199 · Cited by 1,351 · see citing works
Self-citationThe DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
Gasser, S., Orsulic, S., Brown, E. J., & Raulet, D. H. (2005) · Nature · doi:10.1038/nature03884 · Cited by 1,308 · see citing works
Self-citationNatural Killer Cells: Development, Maturation, and Clinical Utilization
Abel, A. M., Yang, C., Thakar, M. S., & Malarkannan, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01869 · Cited by 1,150 · see citing works
Smyth, M. J., Dunn, G. P., & Schreiber, R. D. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)90001-7 · Cited by 872 · see citing works
Regulation of Ligands for the NKG2D Activating Receptor
Raulet, D. H., Gasser, S., Gowen, B. G., Deng, W., & Jung, H. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095951 · Cited by 850 · see citing works
Self-citationThe Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy
Paul, S., & Lal, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01124 · Cited by 829 · see citing works
NK cells and cancer immunosurveillance
Waldhauer, I., & Steinle, A. (2008) · Oncogene · doi:10.1038/onc.2008.267 · Cited by 682 · see citing works
Self-tolerance of natural killer cells
Raulet, D. H., & Vance, R. E. (2006) · Nature reviews. Immunology · doi:10.1038/nri1863 · Cited by 603 · see citing works
Self-citationActivating and inhibitory receptors of natural killer cells
Pegram, H. J., Andrews, D. M., Smyth, M. J., Darcy, P. K., & Kershaw, M. H. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.78 · Cited by 557 · see citing works
Regulation of immune cell function and differentiation by the NKG2D receptor
Zafirova, B., Wensveen, F. M., Gulin, M., & Polić, B. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0797-0 · Cited by 538 · see citing works
Effect of NKG2D ligand expression on host immune responses
Champsaur, M., & Lanier, L. L. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00893.x · Cited by 489 · see citing works
Natural Killer Cells and Cancer
Wu, J., & Lanier, L. L. (2003) · Advances in cancer research · doi:10.1016/s0065-230x(03)90004-2 · Cited by 435 · see citing works
Iannello, A., Thompson, T. W., Ardolino, M., Lowe, S. W., & Raulet, D. H. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130783 · Cited by 414 · see citing works
Self-citationInterplay of natural killer cells and their receptors with the adaptive immune response
Raulet, D. H. (2004) · Nature Immunology · doi:10.1038/ni1114 · Cited by 413 · see citing works
Self-citationNKG2D ligands in tumor immunity
Nausch, N., & Cerwenka, A. (2008) · Oncogene · doi:10.1038/onc.2008.272 · Cited by 409 · see citing works
Oncogenic stress sensed by the immune system: role of natural killer cell receptors
Raulet, D. H., & Guerra, N. (2009) · Nature reviews. Immunology · doi:10.1038/nri2604 · Cited by 396 · see citing works
Self-citationOlson, J. A., Leveson-Gower, D. B., Gill, S. I., Baker, J. B., Beilhack, A., & Negrin, R. S. (2010) · Blood · doi:10.1182/blood-2009-05-222190 · Cited by 387 · see citing works
Promiscuity and the single receptor: NKG2D
Eagle, R. A., & Trowsdale, J. (2007) · Nature Reviews Immunology · doi:10.1038/nri2144 · Cited by 374 · see citing works
Reprogramming of CTLs into natural killer–like cells in celiac disease
Meresse, B., Curran, S. A., Ciszewski, C., Orbelyan, G., Setty, M., Bhagat, G., Lee, L., Tretiakova, M., Semrad, C., Kistner, E., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060028 · Cited by 322 · see citing works
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
Cao, W., Bover, L. C., Cho, M., Wen, X., Hanabuchi, S., Bao, M., Rosen, D. B., Wang, Y., Shaw, J. L., Du, Q., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090547 · Cited by 310 · see citing works
Andoniou, C. E., van Dommelen, S. L. H., Voigt, V., Andrews, D. M., Brizard, G., Asselin‐Paturel, C., Delale, T., Stacey, K. J., Trinchieri, G., & Degli‐Esposti, M. A. (2005) · Nature Immunology · doi:10.1038/ni1244 · Cited by 283 · see citing works
Viral modulation of NK cell immunity
Lodoen, M. B., & Lanier, L. L. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1066 · Cited by 234 · see citing works
Coudert, J. D., Zimmer, J., Tomasello, E., Cebecauer, M., Colonna, M., Vivier, É., & Held, W. (2005) · Blood · doi:10.1182/blood-2005-03-0918 · Cited by 226 · see citing works
Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor
Hamerman, J. A., Ogasawara, K., & Lanier, L. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2001 · Cited by 205 · see citing works
Cytomegalovirus Immune Evasion
Powers, C., DeFilippis, V. R., Malouli, D., & Früh, K. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-77349-8_19 · Cited by 186 · see citing works
Cancer and Innate Immune System Interactions
Liu, Y., & Zeng, G. (2012) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3182518e83 · Cited by 185 · see citing works
Rölle, A., Mousavi‐Jazi, M., Eriksson, M., Odeberg, J., Söderberg‐Nauclér, C., Cosman, D. J., Kärre, K., & Cerboni, C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.902 · Cited by 185 · see citing works
RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Lam, A. R., Bert, N. L., Ho, S. S. W., Shen, Y. J., Tang, M. L. F., Xiong, G. M., Croxford, J. L., Koo, C. X., Ishii, K. J., Akira, S., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1703 · Cited by 179 · see citing works
Self-citationThe DNA Damage Response Arouses the Immune System
Gasser, S., & Raulet, D. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4603 · Cited by 178 · see citing works
Self-citationNKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer
Smyth, M. J., Swann, J. B., Kelly, J. M., Cretney, E., Yokoyama, W. M., Diefenbach, A., Sayers, T. J., & Hayakawa, Y. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041522 · Cited by 169 · see citing works
Self-citationMarshall, A. S. J., Willment, J. A., Lin, H., Williams, D. L., Gordon, S., & Brown, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313127200 · Cited by 164 · see citing works
Regulation of ligands for the activating receptor NKG2D
Mistry, A. R., & O’Callaghan, C. A. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02652.x · Cited by 160 · see citing works
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors
André, P., Castriconi, R., Espéli, M., Anfossi, N., Juarez, T., Hüe, S., Conway, H., Romagné, F., Dondero, A., Nanni, M., et al. (2004) · European Journal of Immunology · doi:10.1002/eji.200324705 · Cited by 157 · see citing works
Self-citationKrmpotić, A., Hasan, M., Loewendorf, A. I., Saulig, T., Halenius, A., Roviš, T. L., Polić, B., Bubić, I., Kriegeskorte, A. K., Pugel, E. P., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041617 · Cited by 149 · see citing works
The role of the NKG2D receptor for tumor immunity
Coudert, J. D., & Held, W. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.008 · Cited by 136 · see citing works
Lo, H. C., Xu, Z., Kim, I. S., Pingel, B. C., Aguirre, S., Kodali, S., Liu, J., Zhang, W., Muscarella, A. M., Hein, S., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0068-9 · Cited by 131 · see citing works
Gillard, G. O., Bivas‐Benita, M., Hovav, A., Grandpre, L. E., Panas, M. W., Seaman, M. S., Haynes, B. F., & Letvin, N. L. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002141 · Cited by 130 · see citing works
IL-21 Enhances Tumor Rejection through a NKG2D-Dependent Mechanism
Takaki, R., Hayakawa, Y., Nelson, A., Sivakumar, P. V., Hughes, S. D., Smyth, M. J., & Lanier, L. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2167 · Cited by 126 · see citing works
Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
Bloch‐Queyrat, C., Fondanèche, M., Chen, R., Yin, L., Relouzat, F., Veillette, A., Fischer, A., & Latour, S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050449 · Cited by 124 · see citing works
Gleimer, M., & Parham, P. (2003) · Immunity · doi:10.1016/s1074-7613(03)00272-3 · Cited by 121 · see citing works
Genetics, genomics, and evolutionary biology of NKG 2D ligands
Carapito, R., & Bahram, S. (2015) · Immunological Reviews · doi:10.1111/imr.12328 · Cited by 118 · see citing works
Li, C., Ge, B., Nicotra, M. L., Stern, J. N. H., Kopcow, H. D., Chen, X., & Strominger, J. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712310105 · Cited by 114 · see citing works
Immunosurveillance and immunotherapy of tumors by innate immune cells
Iannello, A., Thompson, T. W., Ardolino, M., Marcus, A., & Raulet, D. H. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.11.001 · Cited by 105 · see citing works
Self-citationWhang, M. I., Guerra, N., & Raulet, D. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802439 · Cited by 99 · see citing works
Self-citationCao, W., & Bover, L. C. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00867.x · Cited by 98 · see citing works
Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress
Nice, T. J., Coscoy, L., & Raulet, D. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081335 · Cited by 97 · see citing works
Self-citationZalfa, C., & Paust, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.633205 · Cited by 95 · see citing works
Tietze, J. K., Wilkins, D. E. C., Sckisel, G. D., Bouchlaka, M. N., Alderson, K. L., Weiss, J. M., Ames, E., Bruhn, K. W., Craft, N. A., Wiltrout, R. H., et al. (2012) · Blood · doi:10.1182/blood-2011-07-369736 · Cited by 94 · see citing works
Upshaw, J. L., & Leibson, P. J. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.03.001 · Cited by 94 · see citing works
Takada, A., Yoshida, S., Kajikawa, M., Miyatake, Y., Tomaru, U., Sakai, M., Chiba, H., Maenaka, K., Kohda, D., Fugo, K., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1678 · Cited by 89 · see citing works
The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease
Stojanovic, A., Correia, M. P., & Cerwenka, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00827 · Cited by 86 · see citing works
NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
Siemaszko, J., Marzec-Przyszlak, A., & Bogunia‐Kubik, K. (2021) · Cells · doi:10.3390/cells10061420 · Cited by 88 · see citing works
Human Natural Killer Receptors, Co‐Receptors, and Their Ligands
Biassoni, R. (2009) · Current Protocols in Immunology · doi:10.1002/0471142735.im1410s84 · Cited by 80 · see citing works
Mace, E. M., Monkley, S. J., Critchley, D. R., & Takei, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.948 · Cited by 74 · see citing works
Innate Immune Recognition and Suppression of Tumors
Hayakawa, Y., & Smyth, M. J. (2006) · Advances in cancer research · doi:10.1016/s0065-230x(06)95008-8 · Cited by 71 · see citing works
Konjević, G. M., Martinović, K. M., Jurišić, V., Babović, N. L., & Spužić, I. (2009) · Biomarkers · doi:10.1080/13547500902814658 · Cited by 69 · see citing works
Zloza, A., Kohlhapp, F. J., Lyons, G. E., Schenkel, J. M., Moore, T. V., Lacek, A. T., O’Sullivan, J. A., Varanasi, V., Williams, J. W., Jagoda, M. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2683 · Cited by 66 · see citing works
Rodríguez‐Rodero, S., Gonzalez, S. R., Rodrigo, L., Fernández-Morera, J. L., Martı́nez-Borra, J., López‐Vázquez, A., & López‐Larrea, C. (2007) · European Journal of Immunology · doi:10.1002/eji.200737031 · Cited by 65 · see citing works
Ras Activation Induces Expression of Raet1 Family NK Receptor Ligands
Liu, X. V., Ho, S. S. W., Tan, J. J., Kamran, N., & Gasser, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200965 · Cited by 60 · see citing works
Recognition of infected cells by natural killer cells
Carayannopoulos, L. N., & Yokoyama, W. M. (2003) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.11.003 · Cited by 60 · see citing works
NKG2D receptor–mediated NK cell function is regulated by inhibitory Ly49 receptors
Regunathan, J., Chen, Y., Wang, D., & Malarkannan, S. (2004) · Blood · doi:10.1182/blood-2004-03-1075 · Cited by 58 · see citing works
NK Cell Receptors as Tools in Cancer Immunotherapy
Sentman, C. L., Barber, M. A., Barber, A. E., & Zhang, T. (2006) · Advances in cancer research · doi:10.1016/s0065-230x(06)95007-6 · Cited by 56 · see citing works
Wu, J. D., Atteridge, C. L., Wang, X., Seya, T., & Plymate, S. R. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1305 · Cited by 55 · see citing works
Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis
Wang, Y., Liu, C., Fang, Y., Liu, X., Li, W., Liu, S., Liu, Y., Liu, Y., Charreyre, C., Audonnet, J.-C., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-68 · Cited by 53 · see citing works
The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors
Sun, J. C.-Y., & Lanier, L. L. (2009) · Viruses · doi:10.3390/v1030362 · Cited by 52 · see citing works
Immunology of naturally transmissible tumours
Siddle, H. V. T., & Kaufman, J. (2014) · Immunology · doi:10.1111/imm.12377 · Cited by 49 · see citing works
Involvement of an NKG2D Ligand H60c in Epidermal Dendritic T Cell-Mediated Wound Repair
Yoshida, S., Mohamed, R. H., Kajikawa, M., Koizumi, J., Minami, T., Fugo, K., Otsuka, N., Maenaka, K., Yagita∥, H., Chiba, H., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102886 · Cited by 49 · see citing works
Markiewicz, M. A., Wise, E. L., Buchwald, Z. S., Pinto, A. K., Zafirova, B., Polić, B., & Shaw, A. S. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.014 · Cited by 42 · see citing works
Shanker, A., Buferne, M., & Schmitt‐Verhulst, A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03150.x · Cited by 42 · see citing works
Murine NKG2D ligands: “Double, double toil and trouble”
Samarakoon, A., Chu, H., & Malarkannan, S. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.09.035 · Cited by 41 · see citing works
Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response
Jonjić, S. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00085 · Cited by 41 · see citing works
Activation of Natural Killer Cells: Underlying Molecular Mechanisms Revealed
Backström, E., Kristensson, K., & Ljunggren, H. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01475.x · Cited by 41 · see citing works
NKG2D-Dependent Activation of Dendritic Epidermal T Cells in Contact Hypersensitivity
Nielsen, M. M., Dyring‐Andersen, B., Schmidt, J. D., Witherden, D. A., Lovato, P., Woetmann, A., Ødum, N., Poulsen, S. S., Havran, W. L., Geisler, C., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.23 · Cited by 40 · see citing works
Vahlne, G., Becker, S., Brodin, P., & Johansson, M. H. (2007) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2007.02026.x · Cited by 39 · see citing works
Konjević, G. M., Martinović, K. M., Vuletić, A. M., Jurišić, V., & Spužić, I. (2009) · The Journal of Membrane Biology · doi:10.1007/s00232-009-9191-3 · Cited by 35 · see citing works
Zhan, X., Ander, B. P., Jickling, G. C., Turner, R. J., Stamova, B. S., Xu, H., Liu, D., Davis, R. R., & Sharp, F. R. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.189 · Cited by 35 · see citing works
Immunogenetics of the NKG2D ligand gene family
Kasahara, M., & Yoshida, S. (2012) · Immunogenetics · doi:10.1007/s00251-012-0638-9 · Cited by 35 · see citing works
Adekiya, T. A., Aruleba, R. T., Khanyile, S., Masamba, P., Oyinloye, B. E., & Kappo, A. P. (2017) · Vaccines · doi:10.3390/vaccines6010001 · Cited by 34 · see citing works
RAE‐1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres
Popa, N., Cédile, O., Pollet‐Villard, X., Bagnis, C., Durbec, P. L., & Boucraut, J. (2010) · Glia · doi:10.1002/glia.21074 · Cited by 33 · see citing works
Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer
Arina, A., Murillo, O., Dubrot, J., Azpilikueta, A., Alfaro, C., Perez‐Gracia, J. L., Bendandi, M., Palencia, B., Hervás‐Stubbs, S., & Melero, I. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.5.599 · Cited by 32 · see citing works
Fernández-Morera, J. L., Rodríguez‐Rodero, S., Lahoz, C., Tuñon, A., Astudillo, A., García‐Suárez, O., Martı́nez-Borra, J., López‐Vázquez, A., Rodrigo, L., Gonzalez, S. R., et al. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.01.021 · Cited by 32 · see citing works
Deng, M., Guo, R., Zang, S., Rao, J., Li, M., Tang, X., Xia, C., Li, M., Zhang, Z., & He, Q. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c02567 · Cited by 31 · see citing works
Human Natural Killer Receptors, Co‐Receptors, and Their Ligands
Biassoni, R., & Malnati, M. (2018) · Current Protocols in Immunology · doi:10.1002/cpim.47 · Cited by 30 · see citing works
The balancing act: Inhibitory Ly49 regulate NKG2D-mediated NK cell functions
Malarkannan, S. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.04.002 · Cited by 29 · see citing works
Imbalance of NKG2D and its inhibitory counterparts: How does tumor escape from innate immunity?
Zhang, C., Zhang, J., Wei, H., & Tian, Z. (2005) · International Immunopharmacology · doi:10.1016/j.intimp.2005.03.003 · Cited by 28 · see citing works
Zhang, Y., Liang, K., Zhou, X., Zhang, X., Xu, H. J., Dai, H., Song, X., Yang, X., Liu, B., Shi, T., et al. (2023) · Cancer Science · doi:10.1111/cas.15828 · Cited by 27 · see citing works
Konjević, G. M., Martinović, K. M., Vuletić, A. M., & Radenković, S. (2010) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2010.06.013 · Cited by 27 · see citing works
Gillard, G. O., Bivas‐Benita, M., Hovav, A., Grandpre, L. E., Panas, M. W., Seaman, M. S., Haynes, B. F., & Letvin, N. L. (2011) · PLoS Pathogens · doi:10.1371/annotation/b29086ef-e08d-444c-8113-18a6dd429a7c · Cited by 26 · see citing works
Tabayoyong, W., Salas, J. G., Bonde, S., & Zavazava, N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901807 · Cited by 25 · see citing works
Cancer immunotherapy and heat-shock proteins: promises and challenges
Manjili, M. H., Wang, X., MacDonald, I. J., Arnouk, H., Yang, G., Pritchard, M. T., & Subjeck, J. R. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.3.363 · Cited by 25 · see citing works
New twist on the regulation of NKG2D ligand expression
Cerwenka, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090225 · Cited by 24 · see citing works
Raju, S., Kretzmer, L. Z., Koues, O. I., Payton, J. E., Oltz, E. M., Cashen, A. F., Polić, B., Schreiber, R. D., Shaw, A. S., & Markiewicz, M. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501982 · Cited by 24 · see citing works
Orozco‐Morales, M., Sánchez‐García, F. J., Cancela, I. G., Hernández‐Pedro, N., Costoya, J. A., de la Cruz, V. P., Moreno‐Jiménez, S., Sotelo, J., & Pineda, B. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0209-x · Cited by 23 · see citing works
Kondo, M., Maruoka, T., Otsuka, N., Kasamatsu, J., Fugo, K., Hanzawa, N., & Kasahara, M. (2010) · Immunogenetics · doi:10.1007/s00251-010-0438-z · Cited by 23 · see citing works
Abdool, K., Cretney, E., Brooks, A. D., Kelly, J. M., Swann, J. B., Shanker, A., Bere, E. W., Yokoyama, W. M., Ortaldo, J. R., Smyth, M. J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.4.2575 · Cited by 23 · see citing works
Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity
Hyka‐Nouspikel, N., & Phillips, J. H. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00456.x · Cited by 22 · see citing works
Comparative genomics of the NKG 2D ligand gene family
Kasahara, M., & Sutoh, Y. (2015) · Immunological Reviews · doi:10.1111/imr.12320 · Cited by 18 · see citing works
Modular Activating Receptors in Innate and Adaptive Immunity
Berry, R., & Call, M. E. (2017) · Biochemistry · doi:10.1021/acs.biochem.6b01291 · Cited by 17 · see citing works
- Authors
- Diefenbach, A., Hsia, J. K., Hsiung, M. B., & Raulet, D. H.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Raulet, David H.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2003-01-27
- Volume
- 33
- Issue
- 2
- Pages
- 381-391
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2090487140
- Cited by
- 170
- References
- 41
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 5 · 2012: 10
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- NKG2D, NKG2D ligands, natural killer cells, macrophages, antitumor immunity, Rae1, tumor rejection, NK cell activation
- MeSH terms
- Amino Acid Sequence, Animals, Carrier Proteins, Cloning, Molecular, Cytotoxicity, Immunologic, Interferons, Killer Cells, Natural, Ligands, Macrophages, Membrane Proteins, Molecular Sequence Data, Neoplasm Transplantation, Neoplasms, Organ Specificity, Receptors, Immunologic, Recombinant Fusion Proteins, RNA, Messenger, Transfection, Transplantation, Isogeneic, Tumor Cells, Cultured, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens, Lymphoma, T-Cell, Sequence Alignment, Genes, RAG-1, Sequence Homology, Amino Acid, Protein Structure, Tertiary, Mice, Knockout, Mice, Receptors, Natural Killer Cell, NK Cell Lectin-Like Receptor Subfamily K
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