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Cited by 62Cancer Immunotherapy and BiomarkersCervical Cancer and HPV ResearchGene expression and cancer classification

HPVTIMER: A shiny web application for tumor immune estimation in human papillomavirus‐associated cancers

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Liu, Liying, Xie, Yanan, Yang, Hong, Lin, Anqi, Dong, Minjun, Wang, Haitao, Zhang, Cangang, Liu, Zaoqu +4 more·2023·iMeta
DOI 10.1002/imt2.130PMC PMC10989930
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Abstract

The tumor immune microenvironment (TIME) is closely associated with tumor formation, particularly linked to the human papillomavirus (HPV), and regulates tumor initiation, proliferation, infiltration, and metastasis. With the rise of immunotherapy, an increasing amount of sample data used for TIME exploration is available in databases. However, no currently available web tool enables a comprehensive exploration of the TIME of HPV‐associated cancers by leveraging these data. We have developed a web tool called HPV‐associated Tumor Immune MicroEnvironment ExploreR (HPVTIMER), which provides a comprehensive analysis platform that integrates over 10,000 genes and 2290 tumor samples from 65 transcriptome data sets across 8 cancer types sourced from the Gene Expression Omnibus (GEO) database. The tool features four built‐in analysis modules, namely, the differential expression analysis module, correlation analysis module, immune infiltration analysis module, and pathway analysis module. These modules enable users to perform systematic and vertical analyses. We used several analytical modules in HPVTIMER to briefly explore the role of CDKN2A in head and neck squamous cell carcinomas. We expect that HPVTIMER will help users explore the immune microenvironment of HPV‐associated cancers and uncover potential immune regulatory mechanisms and immunotherapeutic targets. HPVTIMER is available at http://www.hpvtimer.com/ .

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  • Virus-associated TME may be related to the dynamic transformation and activity of immune cells.

    “Virus-associated tumor microenvironment (TME) may be related to the dynamic transformation and activity of immune cells103.”

    From Microbiome meets immunotherapy: unlocking the hidden predictors of immune checkpoint inhibitors (2025) · cites this paper as [103]

    The Introduction (page unavailable) links the HPV-associated tumor immune microenvironment to altered immune-cell activation, trafficking, and abundance. It does not establish dynamic transformation over time, and its discussion is limited to HPV-associated cancers rather than virus-associated tumors generally. (LLM, conf=0.82)

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References 63 · Cited by 62

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Authors
Liu, L., Xie, Y., Yang, H., Lin, A., Dong, M., Wang, H., Zhang, C., Liu, Z., Cheng, Q., Zhang, J., Yuan, S., & Luo, P.
Affiliations
  • Zhujiang Hospital (CN)
  • Sir Run Run Shaw Hospital (CN)
  • National Institutes of Health (US)
  • Xi'an Jiaotong University (CN)
  • First Affiliated Hospital of Zhengzhou University (CN)
  • Central South University (CN)
  • University of Hong Kong - Shenzhen Hospital (CN)
Corresponding author
  • Cheng, Quan
  • Zhang, Jian
  • Yuan, Shuofeng
  • Luo, Peng
ORCID
Venue
iMeta
Publisher
Wiley
Published
2023-08
Volume
2
Issue
3
Pages
e130-e130
ISSN
2770-596X (ISSN-L)
DOI
10.1002/imt2.130
PMC
PMC10989930
OpenAlex
W4385786406
Cited by
62
References
63
Citations by year
2026: 17 · 2025: 37 · 2024: 6 · 2023: 2
FWCI
8.02
Type
journal article
Language
en
Open access
Licence
Locations
  • iMeta (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81772457, 81802257, 81871859, 82172750, 82172811)
  • Science and Technology Planning Project of Guangdong Province (2019A030317020)
  • Natural Science Foundation of Guangdong Province (2018A030313846, 2021A1515012593)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Keywords
tumor immune microenvironment, HPV-associated head and neck squamous cell carcinoma, immune cell infiltration, differential gene expression, pathway analysis, immunotherapy targets, web application, CDKN2A

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