Cited by 254Cancer-related Molecular PathwaysLymphoma Diagnosis and TreatmentViral-associated cancers and disorders

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p53 is frequently mutated in Burkitt's lymphoma cell lines

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Farrell, P.J., Allan, G.J., Shanahan, F., Vousden, K.H., Crook, T.·1991·The EMBO Journal

DOI 10.1002/j.1460-2075.1991.tb07837.xPMC PMC452998

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Abstract

A panel of 12 Burkitt's lymphoma cell lines and four other B cell lines were tested for the presence of mutations in p53. Protein analysis using a mutant-specific antibody and sequencing of both cDNA and genomic DNA revealed changes relative to the standard p53 protein sequence in 12 of the 16 lines studied, including 10 of the BL lines. Mutation of p53 in the BL lines was usually accompanied by loss of the other allele of p53. Testing of the mutated p53 cDNAs for gain of transforming activity or loss of growth suppression activity showed that several of the BL mutants were functionally altered from wild-type p53.

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DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937
Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose
Aviv, H., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1408 · Cited by 6,636
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765
Mutations in the p53 gene occur in diverse human tumour types
Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hosteller, R., Cleary, K. R., Signer, S. H., Davidson, N. E., Baylin, S., Devilee, P., et al. (1989) · Nature · doi:10.1038/342705a0 · Cited by 2,730
Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.
McMaster, G. K., & Carmichael, G. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.4835 · Cited by 2,406
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.
Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764

Show all 59 references

Research works printed but not linked: 13

Aviv,H. and Leder,P. (1972) Proc. Nat!. Acad. Sci. USA, 64, 1408-1412.
Dalla-Favera,R., Brejni,M., Erikson,J., Patterson,D., Gallo, R.C. and Croce,C.M. (1982) Proc. Natl. Acad. Sci. USA, 79, 7824-7827.
Eliyahu,D., Michalovitz,D., Eliyahu,S., Pinhasi-Kimhi,O. and Oren,M. (1989) Proc. Natl. Acad. Sci. USA, 86, 8763-8767.
Hinuma,Y. and Grace,J.T. (1967) Proc. Soc. Exp. Biol. Med., 124, 107-111.
Hollstein,M.C., Metcalf,R.A., Welsh,J.A., Montesano,R. and Harris,C.C. (1990) Proc. Natl. Acad. Sci. USA, 87, 9958-9961.
Lenoir,G.M., Vuillaume,M. and Bonnardel,C. (1985) IARC Publications No 60, pp. 309-318.
McMaster,G.K. and Carmichael,G.C. (1977) Proc. Natl. Acad. Sci. USA, 74, 4835-4838.
Miller,G., Shope,T., Lisco,H., Stitt,D. and Lipman,M. (1972) Proc. Natl. Acad. Sci. USA, 69, 383-387
Rodrigues,N.R., Rowan,A., Smith,M.E.G., Kerr,I.B., Bodmer,W.F., Gannon,J.F. and Lane,D.P. (1990) Proc. Natl. Acad. Sci. USA, 87, 7555 -7559.
Sanger,F., Nicklen,S. and Coulson,A.R. (1977) Proc. Natl. Acad. Sci. USA, 74, 5463-5467.
Thomas,P.S. (1980) Proc. Natl. Acad. Sci. USA, 77, 5201-5205.
van Santen,V., Cheung,A. and Kieff,E. (1981) Proc. Natl. Acad. Sci. USA, 78, 1930-1934
zur Hausen,H., Schulte-Holthausen,H., Klein,G., Henle,W., Henle,G., Clifford,P. and Santesson,L. (1970) Nature, 228, 1056-1058. Received on April 30, 1991; revised on June 5, 1991 Note added in proof Mutations of p53 in BL have also been reported recently by Gaidano et al. (1991) (Proc. Natl. Acad. Sci. USA, 88. 5413-5417).

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Rowe, M., Fitzsimmons, L., & Bell, A. I. (2014) · 癌症：英文版 · doi:10.5732/cjc.014.10190 · Cited by 80
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Fitzsimmons, L., & Kelly, G. L. (2017) · Viruses · doi:10.3390/v9110339 · Cited by 79
Immunolocalization of Human p14ARF to the Granular Component of the Interphase Nucleolus
Lindström, M. S., Klangby, U., Inoue, R., Pisa, P., Wiman, K. G., & Asker, C. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4854 · Cited by 77
Lowp53 protein expression in salivary gland tumours compared with lung carcinomas
Soini, Y., Kamel, D., Nuorva, K., Lane, D. P., Vähäkangas, K., & Pääkkö, P. K. (1992) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01606914 · Cited by 75
Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity
Chen, W., & Cooper, N. R. (1996) · Journal of Virology · doi:10.1128/jvi.70.7.4849-4853.1996 · Cited by 72
p53 alterations in human leukemia–lymphoma cell lines: in vitroartifact or prerequisite for cell immortalization?
Drexler, H. G., Fombonne, S., Matsuo, Y., Hu, Z.-B., Hamaguchi, H., & Uphoff, C. (2000) · Leukemia · doi:10.1038/sj.leu.2401604 · Cited by 71
Inhibition of S-Phase Cyclin-Dependent Kinase Activity Blocks Expression of Epstein-Barr Virus Immediate-Early and Early Genes, Preventing Viral Lytic Replication
Kudoh, A., Daikoku, T., Sugaya, Y., Isomura, H., Fujita, M., Kiyono, T., Nishiyama, Y., & Tsurumi, T. (2003) · Journal of Virology · doi:10.1128/jvi.78.1.104-115.2004 · Cited by 67
EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins
Fitzsimmons, L., Cartlidge, R., Chang, C. W. T., Sejic, N., Galbraith, L. C. A., Suraweera, C. D., Croom-Carter, D. S. G., Dewson, G., Tierney, R. J., Bell, A. I., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0435-1 · Cited by 67
Epstein–Barr virus and its role in the pathogenesis of Burkitt's lymphoma: An unresolved issue
Bornkamm, G. W. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.07.002 · Cited by 64
Initial testing of the MDM2 inhibitor RG7112 by the pediatric preclinical testing program
Carol, H., Reynolds, C. P., Kang, M. H., Keir, S. T., Maris, J. M., Gorlick, R. G., Kolb, E. A., Billups, C. A., Geier, B., Kurmasheva, R. T., et al. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24235 · Cited by 64
p53 Immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours
Soini, Y., Vähäkangas, K., Nuorva, K., Kamel, D., Lane, D. P., & Pääkkö, P. K. (1992) · The Journal of Pathology · doi:10.1002/path.1711680106 · Cited by 62
The Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic Mice
Wilson, J. B., & Levine, A. J. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77633-5_48 · Cited by 62
Viruses and tumours – an update
Talbot, S. J., & Crawford, D. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2003.11.039 · Cited by 61
Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas
Soini, Y., Pääkkö, P. K., Nuorva, K., Kamel, D., Lane, D. P., & Vähäkangas, K. (1992) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01611179 · Cited by 61
Inactivation of the ARF–MDM-2–p53 pathway in sporadic Burkitt's lymphoma in children
Wilda, M., Bruch, J., Harder, L., Rawer, D., Reiter, A., Borkhardt, A., & Woessmann, W. (2003) · Leukemia · doi:10.1038/sj.leu.2403254 · Cited by 59
Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas
Nakamura, H., Said, J. W., Cw, M., & Koeffler, H. (1993) · Blood · doi:10.1182/blood.v82.3.920.920 · Cited by 60
UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation
Wu, H., & Leng, R. P. (2011) · Cell Cycle · doi:10.4161/cc.10.12.15882 · Cited by 59
Inactivation of Nuclear Factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells
Nazari, M., Ghorbani, A., Hekmatdoost, A., Jeddi‐Tehrani, M., & Zand, H. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.053 · Cited by 58
Bcl-2 Does Not Protect Burkitt's Lymphoma Cells From Oxidant-Induced Cell Death
Lee, Y.-J., & Shacter, E. B. (1997) · Blood · doi:10.1182/blood.v89.12.4480 · Cited by 58
Expression of p16INK4A and p14ARF in hematological malignancies
Taniguchi, T., Chikatsu, N., Takahashi, S., Fujita, A., Uchimaru, K., Asano, S., Fujita, T., & Motokura, T. (1999) · Leukemia · doi:10.1038/sj.leu.2401557 · Cited by 55
Alterations of the p53 tumor suppressor gene in diffuse large cell lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes
Farrugia, M. M., Duan, L., Reis, M., Ngan, B., & Berinstein, N. L. (1994) · Blood · doi:10.1182/blood.v83.1.191.191 · Cited by 54
Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma.
Sun, Y., Nakamura, K., Wendel, E. J., & Colburn, N. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2827 · Cited by 54
Resistance to TGF-β1 correlates with a reduction of TGF-β type II receptor expression in Burkitt’s lymphoma and Epstein–Barr virus-transformed B lymphoblastoid cell lines
Inman, G. J., & Allday, M. J. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-6-1567 · Cited by 53
Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus
Sinclair, A. J., & Farrell, P. J. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5461-5468.1995 · Cited by 52
Self-citation
DNA Methylation and cancer
Spruck, C., Rideout, W. M., & Jones, P. A. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9118-9_22 · Cited by 52
Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and In Vivo Studies
Angelova, A. L., Aprahamian, M., Balboni, G., Delecluse, H., Feederle, R., Kiprianova, I., Grekova, S. P., Galabov, A. S., Witzens‐Harig, M., Ho, A. D., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.78 · Cited by 51
Mycosis fungoides: Expression of C-myc p62 p53, bcl-2and PCNA Proteins and Absence of Association with Epstein-Barr Virus
Kanavaros, P., Ioannidou, D., Tzardi, M. N., Datseris, G., Katsantonis, J., Delidis, G., & Tosca, A. D. (1994) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80423-1 · Cited by 51
The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults.
Banker, D. E., Radich, J. P., Becker, A., Kerkof, K., Norwood, T. H., Willman, C. L., & Appelbaum, F. R. (1998) · PubMed · Cited by 49
Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: Frequent loss of 19p13.3 and gain of 19q13.1-13.2
Höglund, M., Gorunova, L., Andrén‐Sandberg, Å., Dawiskiba, S., Mitelman, F., & Johansson, B. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199801)21:1 · Cited by 57
Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-γ activation and NF-κB suppression
Zand, H., Rahimipour, A., Salimi, S., & Shafiee, S. M. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9838-x · Cited by 49
Viruses and Lymphomas
Pagano, J. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmp020056 · Cited by 49
p53 Mutations, c-myc and bcl-2 Rearrangements in Human Non-Hodgkin's Lymphoma Cell Lines
Chang, H., Blondal, J. A., Benchimol, S., Minden, M. D., & Messner, H. A. (1995) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199509059672 · Cited by 45
Alterations of the p53 gene in Epstein-Barr virus-associated immunodeficiency-related lymphomas
Edwards, R. H., & Raab‐Traub, N. (1994) · Journal of Virology · doi:10.1128/jvi.68.3.1309-1315.1994 · Cited by 44

Authors: Farrell, P. J., Allan, G. J., Shanahan, F., Vousden, K. H., & Crook, T.
Affiliations: St Mary's Hospital (GB)
ORCID: Farrell, P.J.
Shanahan, F.
Vousden, K.H.
Crook, T.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1991-10-01
Volume: 10
Issue: 10
Pages: 2879-2887
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1991.tb07837.x
PMC: PMC452998
OpenAlex: W196344020
Cited by: 254
References: 59
Citations by year: 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 12 · 2013: 1 · 2012: 14
FWCI: 9.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: p53, Burkitt lymphoma, TP53 mutation, B-cell lymphoma cell lines, loss of heterozygosity, tumor suppressor
MeSH terms: Alleles, Amino Acid Sequence, Animals, Base Sequence, Burkitt Lymphoma, DNA, DNA, Neoplasm, Humans, Molecular Sequence Data, Mutation, Precipitin Tests, RNA, Neoplasm, Tumor Cells, Cultured, Blotting, Southern, Blotting, Northern, Blotting, Western, Polymerase Chain Reaction, Tumor Suppressor Protein p53

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p53 is frequently mutated in Burkitt's lymphoma cell lines

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