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p53 is frequently mutated in Burkitt's lymphoma cell lines
Open accessAbstract
A panel of 12 Burkitt's lymphoma cell lines and four other B cell lines were tested for the presence of mutations in p53. Protein analysis using a mutant-specific antibody and sequencing of both cDNA and genomic DNA revealed changes relative to the standard p53 protein sequence in 12 of the 16 lines studied, including 10 of the BL lines. Mutation of p53 in the BL lines was usually accompanied by loss of the other allele of p53. Testing of the mutated p53 cDNAs for gain of transforming activity or loss of growth suppression activity showed that several of the BL mutants were functionally altered from wild-type p53.
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“The cell line RAJI, which harbors the loss-of-function mutant alleles R213Q and Y234H [34–36] for p53 targets including TLR3 and p21 (Supplementary Figure S4A), was treated with the reactivating drugs RITA [36] and PRIMA-1 [37] as well as with the anticancer drugs doxorubicin (DXR) and 5-fluorouracil (5FU) to induce p53.”
From Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells (2016) · cites this paper as [35]
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Metadata
- Authors
- Farrell, P. J., Allan, G. J., Shanahan, F., Vousden, K. H., & Crook, T.
- Affiliations
- St Mary's Hospital (GB)
- Venue
- The EMBO Journal
- Published
- 1991-10-01
- Volume
- 10
- Issue
- 10
- Pages
- 2879-2887
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC452998
- OpenAlex
- W196344020
- Cited by
- 254
- References
- 59
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 12 · 2013: 1 · 2012: 14
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- p53, Burkitt lymphoma, TP53 mutation, B-cell lymphoma cell lines, loss of heterozygosity, tumor suppressor
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Base Sequence, Burkitt Lymphoma, DNA, DNA, Neoplasm, Humans, Molecular Sequence Data, Mutation, Precipitin Tests, RNA, Neoplasm, Tumor Cells, Cultured, Blotting, Southern, Blotting, Northern, Blotting, Western, Polymerase Chain Reaction, Tumor Suppressor Protein p53
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