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Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

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Backer, J.M., Myers, M.G., Shoelson, S.E., Chin, D.J., Sun, X.J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E.Y., Schlessinger, J.·1992·The EMBO Journal

DOI 10.1002/j.1460-2075.1992.tb05426.x

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
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Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.
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Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
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Phosphatidylinositol-3-OH kinase direct target of Ras
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
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IRS proteins and the common path to diabetes
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Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting
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Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
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Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
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Expression and function of IRS-1 in insulin signal transmission.
Sun, X. J., Miralpeix, M., Myers, M. G., Glasheen, E. M., Backer, J. M., Kahn, C. R., & White, M. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41723-1 · Cited by 326
Self-citation
Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
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Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling
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Hon, W.-C., Berndt, A., & Williams, R. L. (2012) · Oncogene · doi:10.1038/onc.2011.532 · Cited by 129
Melatonin stimulates glucose transport via insulin receptor substrate‐1/phosphatidylinositol 3‐kinase pathway in C2C12 murine skeletal muscle cells
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Specific Increase in p85α Expression in Response to Dexamethasone Is Associated with Inhibition of Insulin-like Growth Factor-I Stimulated Phosphatidylinositol 3-Kinase Activity in Cultured Muscle Cells
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Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
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Authors: Backer, J. M., Myers, M. G., Shoelson, S. E., Chin, D. J., Sun, X. J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E. Y., & Schlessinger, J.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1992-09
Volume: 11
Issue: 9
Pages: 3469-3479
ISSN: 0261-4189 (ISSN-L)
DOI: 10.1002/j.1460-2075.1992.tb05426.x
OpenAlex: W1547466369
Cited by: 1,008
References: 2
FWCI: 35.63
Type: journal article
Language: en
Open access: bronze

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Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

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