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Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

Schu, Peter V., Takegawa, Kaoru, Fry, Michael J., Stack, Jeffrey H., Waterfield, Michael D., Emr, Scott D.·1993·Science
DOI 10.1126/science.8385367
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Abstract

The VPS 34 gene product (Vps34p) is required for protein sorting to the lysosome-like vacuole of the yeast Saccharomyces cerevisiae . Vps34p shares significant sequence similarity with the catalytic subunit of bovine phosphatidylinositol (PI) 3-kinase [the 110-kilodalton (p110) subunit of PI 3-kinase], which is known to interact with activated cell surface receptor tyrosine kinases. Yeast strains deleted for the VPS 34 gene or carrying vps 34 point mutations lacked detectable PI 3-kinase activity and exhibited severe defects in vacuolar protein sorting. Overexpression of Vps34p resulted in an increase in PI 3-kinase activity, and this activity was specifically precipitated with antisera to Vps34p. VPS 34 encodes a yeast PI 3-kinase, and this enzyme appears to regulate intracellular protein trafficking decisions.

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Research works printed but not linked: 35

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Metadata

Authors
Schu, P. V., Takegawa, K., Fry, M. J., Stack, J. H., Waterfield, M. D., & Emr, S. D.
Affiliations
  • Division of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093.
  • Ludwig Institute for Cancer Research, London, W1P 8BT, United Kingdom.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-04-02
Volume
260
Issue
5104
Pages
88-91
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.8385367
Cited by
778
References
0
Language
en

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