Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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Molecular mechanisms of mTOR-mediated translational control

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The emerging mechanisms of isoform-specific PI3K signalling

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The nuts and bolts of AGC protein kinases

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The PI3K Pathway As Drug Target in Human Cancer

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

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The multifunctional NS1 protein of influenza A viruses

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Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.

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Protein kinases: evolution of dynamic regulatory proteins

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The Identification of 2-(1 H -Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2- d ]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

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CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

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Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

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Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

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Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

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Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

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The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

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The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

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Targeting phosphoinositide 3-kinase—Moving towards therapy

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PTEN-deficient cancers depend on PIK3CB

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Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

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PI 3‐kinase is a dual specificity enzyme: autoregulation by an intrinsic protein‐serine kinase activity.

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A helix scaffold for the assembly of active protein kinases

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Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

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Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

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An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

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Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

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Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

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Rare cancer-specific mutations in PIK3CA show gain of function

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Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

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The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ

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Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

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The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

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Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

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Emerging common themes in regulation of PIKKs and PI3Ks

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A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

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The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

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Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

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Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

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Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling

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Structural Evolution of the Protein Kinase-Like Superfamily

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Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

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Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase

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Defining the conserved internal architecture of a protein kinase

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Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide

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Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase

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Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

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Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence

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Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

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Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ

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A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

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Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

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Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

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Regulation of the p85/p110α Phosphatidylinositol 3′-Kinase

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Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex

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Agonist-dependent Recruitment of Phosphoinositide 3-Kinase to the Membrane by β-Adrenergic Receptor Kinase 1

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Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils

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Activity of any class IA PI3K isoform can sustain cell proliferation and survival

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Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair

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p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ

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SHP-1 Regulates Lck-induced Phosphatidylinositol 3-Kinase Phosphorylation and Activity

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Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN

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Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α

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The p85 Regulatory Subunit Controls Sequential Activation of Phosphoinositide 3-Kinase by Tyr Kinases and Ras

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PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes

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Characterization of p87PIKAP, a Novel Regulatory Subunit of Phosphoinositide 3-Kinase γ That Is Highly Expressed in Heart and Interacts with PDE3B

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PI3K inhibition in inflammation: Toward tailored therapies for specific diseases

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Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

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Role of class II phosphoinositide 3-kinase in cell signalling

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Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

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PDK1: The Major Transducer of PI 3-Kinase Actions

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Oncogenic signaling of class I PI3K isoforms

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Phosphoinositide 3-kinases as drug targets in cancer

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Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

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BYL719, a new α‐specific PI3K inhibitor: Single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma

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PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

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The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

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Calmodulin and PI3K Signaling in KRAS Cancers

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A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

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Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

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Two modes of integrin activation form a binary molecular switch in adhesion maturation

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate

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The structural basis for Ras activation of PI3Kα lipid kinase

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The Structural Basis of PI3K Cancer Mutations: From Mechanism to Therapy

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Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

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The structural basis for mTOR function

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Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes

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Using Hydrogen–Deuterium Exchange Mass Spectrometry to Examine Protein–Membrane Interactions

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PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors

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Properties of FDA-approved small molecule phosphatidylinositol 3-kinase inhibitors prescribed for the treatment of malignancies

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Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα

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In Silico Modeling

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Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking

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Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity

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Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

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Structure of the human ATM kinase and mechanism of Nbs1 binding

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KLF4 mediates the link between TGF-β1-induced gene transcription and H3 acetylation in vascular smooth muscle cells

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Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth

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Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease

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Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange–MS (HDX–MS)

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p87 and p101 Subunits Are Distinct Regulators Determining Class IB Phosphoinositide 3-Kinase (PI3K) Specificity

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microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion

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Does Ras Activate Raf and PI3K Allosterically?

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Role of Phosphatidylinositol 3,4,5-Trisphosphate in Cell Signaling

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Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction

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The PI3K/Akt/mTOR axis in colorectal cancer: Oncogenic alterations, non‐coding RNAs, therapeutic opportunities, and the emerging role of nanoparticles

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Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

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A Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma

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The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions

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Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease

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IFC - Author Index

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Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3- kinase Inhibitor Reveals a Switch Governing

Potency, L. K. (2008)

PI3-Kinase Inhibition

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