The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
Phosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Cited by
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Rho GTPases and their effector proteins
BISHOP, A. L., & HALL, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,575
ROCKs: multifunctional kinases in cell behaviour
Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y., & Kaibuchi, K. (1997) · Science · doi:10.1126/science.275.5304.1308 · Cited by 1,077
Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity
Amano, M., Nakayama, M., & Kaibuchi, K. (2010) · Cytoskeleton · doi:10.1002/cm.20472 · Cited by 994
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915
Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. M., & Narumiya, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3044 · Cited by 823
Self-citationRho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions
Julian, L., & Olson, M. F. (2014) · Small GTPases · doi:10.4161/sgtp.29846 · Cited by 550
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
Perona, R., Montaner, S., Saniger, L., Sánchez-Pérez, I., Bravo, R., & Lacal, J. C. (1997) · Genes & Development · doi:10.1101/gad.11.4.463 · Cited by 519
Poltavets, V., Kochetkova, M., Pitson, S. M., & Samuel, M. S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00431 · Cited by 377
Taxonomy and function of C1 protein kinase C homology domains
Hurley, J. H., Newton, A. C., Parker, P. J., Blumberg, P. M., & Nishizuka, Y. (1997) · Protein Science · doi:10.1002/pro.5560060228 · Cited by 362
PDK1 Regulates Cancer Cell Motility by Antagonising Inhibition of ROCK1 by RhoE
Pinner, S., & Sahai, E. (2008) · Nature Cell Biology · doi:10.1038/ncb1675 · Cited by 267
Rho kinase in the regulation of cell death and survival
Shi, J., & Wei, L. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0009-7 · Cited by 254
ROCK inhibition in models of neurodegeneration and its potential for clinical translation
Koch, J. C., Tatenhorst, L., Roser, A.-E., Saal, K.-A., Tönges, L., & Lingor, P. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.03.008 · Cited by 239
Knipe, R. S., Tager, A. M., & Liao, J. K. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009381 · Cited by 233
Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
Zhang, W., Vazquez, L., Apperson, M., & Kennedy, M. B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00096.1999 · Cited by 190
Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue
Ihara, K., Muraguchi, S., Kato, M., Shimizu, T., Shirakawa, M., Kuroda, S., Kaibuchi, K., & Hakoshima, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9656 · Cited by 190
Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK
Pedrini, S., Carter, T. L., Prendergast, G., Petanceska, S., Ehrlich, M. E., & Gandy, S. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020018 · Cited by 154
Takata, M., Tanaka, H., Kimura, M., Nagahara, Y., Tanaka, K., Kawasaki, K., Seto, M., Tsuruma, K., Shimazawa, M., & Hara, H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12277 · Cited by 131
The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytes
Miñambres, R., Guasch, R. M., Perez-Aragó, A., & Guerri, C. (2006) · Journal of Cell Science · doi:10.1242/jcs.02723 · Cited by 94
Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2
Singh, U. S., Kunar, M. T., Kao, Y., & Baker, K. M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2413 · Cited by 88
The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair
Oggero, S., Austin-Williams, S., & Norling, L. V. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01479 · Cited by 85
Nalkurthi, C., Schroder, W. A., Melino, M., Irvine, K. M., Nyuydzefe, M., Chen, W., Liu, J., Teng, M. W. L., Hill, G. R., Bertolino, P., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2021.100386 · Cited by 75
Dual Roles for RHOA/RHO-Kinase In the Regulated Trafficking of a Voltage-sensitive Potassium Channel
Stirling, L., Williams, M. R., & Morielli, A. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1074 · Cited by 45
Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington’s Disease
Narayanan, K. L., Chopra, V., Rosas, H. D., Malarick, K., & Hersch, S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9147-9 · Cited by 37
Torres-Cruz, F. M., Rodríguez-Cruz, F., Escobar-Herrera, J., Barragán-Andrade, N., Basurto-Islas, G., Ripova, D., Ávila, J., & Garcia-Sierra, F. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150396 · Cited by 19
Metadata
- Authors
- Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Saito, Y., Kakizuka, A., Morii, N., & Narumiya, S.
- Venue
- The EMBO Journal
- Published
- 1996-04
- Volume
- 15
- Issue
- 8
- Pages
- 1885-1893
- ISSN
- 0261-4189 (ISSN-L)
- OpenAlex
- W81352928
- Cited by
- 887
- References
- 3
- FWCI
- 18.93
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.