CoChat
Sign Up
Cited by 85Extracellular vesicles in diseaseAngiogenesis and VEGF in CancerCaveolin-1 and cellular processes

The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair

Open access
Oggero, Silvia, Austin-Williams, Shani, Norling, Lucy Victoria·2019·Frontiers in Pharmacology
DOI 10.3389/fphar.2019.01479PMC PMC6928593
Open this paper in CoChat — free accountOpen PDF

Abstract

Extracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space. Composed of a lipid bilayer encompassing both soluble cytosolic material and nuclear components, these organelles have been recently described as novel regulators of intercellular communication between adjacent and remote cells. Due to their diversified composition and biological content, they portray specific signatures of cellular activation and pathological processes, their potential as diagnostic and prognostic biomarkers has raised significant interest in cardiovascular diseases. Circulating vesicles, especially those released from platelets, leukocytes, and endothelial cells are found to play a critical role in activating several fundamental cells within the vasculature, including endothelial cells and vascular smooth muscle cells. Their intrinsic activity and immunomodulatory properties lends them to not only promote vascular inflammation, but also enhance tissue regeneration, vascular repair, and indeed resolution. In this review we aim to recapitulate the recent findings concerning the roles played by EVs that originate from different circulating cells, with particular reference to their action on the endothelium. We focus herein, on the interaction of platelet and leukocyte EVs with the endothelium. In addition, their potential biological function in promoting tissue resolution and vascular repair will also be discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphar.2019.01479

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Platelet EVs can carry regulatory and pro-neurogenic factors.

    “Given that platelet EVs can also carry regulatory and pro‐neurogenic factors, 50 , 51 , 52 this profile may reflect an altered platelet state favoring vesicle‐mediated communication over thrombosis.”

    From Plasma extracellular vesicles from <i>APOE3</i> Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease (2026) · cites this paper as [50]

    The “Extracellular Vesicles in Vascular Inflammation” section reports that platelet-derived EVs carry growth factors and other components with immunomodulatory effects. The “EVs in Tissue Resolution and Repair” section discusses neurogenesis, but attributes it to mesenchymal stem cell-derived EVs, not platelet EVs. This source therefore supports regulatory cargo but not the pro-neurogenic part of the claim. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 232

  1. Abad Hussein M N Nieuwland R. Hau C. M. Evers L. M. Meesters E. W. Sturk A. (2005). Cell-derived microparticles contain caspase 3 in vitro and in vivo. J. Thromb. Haemost. 3, 888– 896. 10.1111/j.1538-7836.2005.01240.x 15869582 · DOI
  2. Admyre C. Johansson S. M. Qazi K. R. Filén J.-J. Lahesmaa R. Norman M. (2007). Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 179, 1969– 1978. 10.4049/jimmunol.179.3.1969 17641064 · DOI
  3. Aharon A. Tamari T. Brenner B. (2008). Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells. Thromb. Haemost. 100, 878– 885. 10.1160/TH07-11-0691 18989533 · DOI
  4. Arslan F. Lai R. C. Smeets M. B. Akeroyd L. Choo A. Aguor E. N. E. (2013). Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res. 10, 301– 312. 10.1016/j.scr.2013.01.002 23399448 · DOI
  5. Badimon L. Padró T. Vilahur G. (2012). Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. Eur. Hear. J. Acute Cardiovasc. Care 1, 60– 74. 10.1177/2048872612441582 PMC3760546 24062891 · DOI
  6. Bala S. Marcos M. Kodys K. Csak T. Catalano D. Mandrekar P. (2011). Up-regulation of MicroRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease. J. Biol. Chem. 286, 1436– 1444. 10.1074/jbc.M110.145870 21062749 PMC3020752 · DOI
  7. Balaj L. Lessard R. Dai L. Cho Y.-J. Pomeroy S. L. Breakefield X. O. (2011). Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat. Commun. 2, 180. 10.1038/ncomms1180 21285958 PMC3040683 · DOI
  8. Banks W. A. Gray A. M. Erickson M. A. Salameh T. S. Damodarasamy M. Sheibani N. (2015). Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J. Neuroinflammation 12, 223. 10.1186/s12974-015-0434-1 26608623 PMC4660627 · DOI · Paper page
  9. Bao H. Yao Q.-P. Huang K. Chen X.-H. Han Y. Jiang Z.-L. (2017). Platelet-derived miR-142-3p induces apoptosis of endothelial cells in hypertension. Cell. Mol. Biol. 63, 3. 10.14715/cmb/2017.63.4.1 28478796 · DOI
  10. Bao H. Chen Y.-X. Huang K. Zhuang F. Bao M. Han Y. (2018). Platelet-derived microparticles promote endothelial cell proliferation in hypertension via miR-142-3p. FASEB J. 32, 3912– 3923. 10.1096/fj.201701073R 29481306 · DOI
  11. Bardelli C. Amoruso A. Federici Canova D. Fresu L. Balbo P. Neri T. (2012). Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. Br. J. Pharmacol. 165, 716– 728. 10.1111/j.1476-5381.2011.01593.x 21745193 PMC3315043 · DOI
  12. Barry O. P. Praticò D. Lawson J. A. FitzGerald G. A. (1997). Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J. Clin. Invest. 99, 2118– 2127. 10.1172/JCI119385 9151784 PMC508042 · DOI
  13. Barry O. P. Kazanietz M. G. Praticò D. FitzGerald G. A. (1999). Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/Mitogen-activated protein kinase-dependent pathway. J. Biol. Chem. 274, 7545– 7556. 10.1074/jbc.274.11.7545 10066822 · DOI
  14. Barwari T. Joshi A. Mayr M. (2016). MicroRNAs in cardiovascular disease. J. Am. Coll. Cardiol. 68, 2577– 2584. 10.1016/j.jacc.2016.09.945 27931616 · DOI
  15. Beaudoin A. R. Grondin G. (1991). Shedding of vesicular material from the cell surface of eukaryotic cells: different cellular phenomena. Biochim. Biophys. Acta-Rev. Biomembr. 1071, 203– 219. 10.1016/0304-4157(91)90014-N 1958687 · DOI
  16. Bonifacino J. S. Glick B. S. (2004). The mechanisms of vesicle budding and fusion. Cell 116, 153– 166. 10.1016/S0092-8674(03)01079-1 14744428 · DOI
  17. Bretz N. P. Ridinger J. Rupp A.-K. Rimbach K. Keller S. Rupp C. (2013). Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via toll-like receptor signaling. J. Biol. Chem. 288, 36691– 36702. 10.1074/jbc.M113.512806 24225954 PMC3868779 · DOI
  18. Brill A. Dashevsky O. Rivo J. Gozal Y. Varon D. (2005). Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. Cardiovasc. Res. 67, 30– 38. 10.1016/j.cardiores.2005.04.007 15878159 · DOI
  19. Brodsky S. V. Malinowski K. Golightly M. Jesty J. Goligorsky M. S. (2002). Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential. Circulation 106, 2372– 2378. 10.1161/01.CIR.0000033972.90653.AF 12403669 · DOI
  20. Brogan P. A. Shah V. Brachet C. Harnden A. Mant D. Klein N. (2004). Endothelial and platelet microparticles in vasculitis of the young. Arthritis Rheumatol. 50, 927– 936. 10.1002/art.20199 15022336 · DOI
  21. Brown G. T. McIntyre T. M. (2011). Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β–Rich Microparticles. J. Immunol. 186, 5489– 5496. 10.4049/jimmunol.1001623 21430222 PMC3100655 · DOI
  22. Buschow S. I. Nolte-‘t Hoen E. N. M. van Niel G. Pols M. S. Broeke T. Lauwen M. (2009). MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic 10, 1528– 1542. 10.1111/j.1600-0854.2009.00963.x 19682328 · DOI
  23. Bustos M. Saadi S. Platt J. L. (2001). Platelet-mediated activation of endothelial cells: implications for the pathogenesis of transplant rejection1. Transplantation 72, 509– 515. 10.1097/00007890-200108150-00025 11502984 · DOI
  24. Cambier L. Couto G. Ibrahim A. Echavez A. K. Valle J. Liu W. (2017). Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL -10 expression and secretion. EMBO Mol. Med. 9, 337– 352. 10.15252/emmm.201606924 28167565 PMC5331234 · DOI
  25. Chairoungdua A. Smith D. L. Pochard P. Hull M. Caplan M. J. (2010). Exosome release of β-catenin: A novel mechanism that antagonizes Wnt signaling. J. Cell Biol. 190, 1079– 1091. 10.1083/jcb.201002049 20837771 PMC3101591 · DOI
  26. Charrin S. Jouannet S. Boucheix C. Rubinstein E. (2014). Tetraspanins at a glance. J. Cell Sci. 127, 3641– 3648. 10.1242/jcs.154906 25128561 · DOI
  27. Chen Q. Wang H. Liu Y. Song Y. Lai L. Han Q. (2012). Inducible microrna-223 down-regulation promotes tlr-triggered il-6 and il-1β production in macrophages by targeting stAT3. PloS One 7, e42971. 10.1371/journal.pone.0042971 22937006 PMC3427313 · DOI
  28. Chen L. Wang Y. Pan Y. Zhang L. Shen C. Qin G. (2013). Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury. Biochem. Biophys. Res. Commun. 431, 566– 571. 10.1016/j.bbrc.2013.01.015 23318173 PMC3732190 · DOI
  29. Chironi G. Simon A. Hugel B. Pino M. D. Gariepy J. Freyssinet J. M. (2006). Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects. Arterioscler. Thromb. Vasc. Biol. 26, 2775– 2780. 10.1161/01.ATV.0000249639.36915.04 17038634 · DOI
  30. Chistiakov D. A. Sobenin I. A. Orekhov A. N. (2012). Strategies to deliver microRNAs as potential therapeutics in the treatment of cardiovascular pathology. Drug Deliv. 19, 392– 405. 10.3109/10717544.2012.738436 23173580 · DOI
  31. Chiva-Blanch G. Suades R. Crespo J. Vilahur G. Arderiu G. Padró T. (2016). CD3 + /CD45 + and SMA-α + circulating microparticles are increased in individuals at high cardiovascular risk who will develop a major cardiovascular event. Int. J. Cardiol. 208, 147– 149. 10.1016/j.ijcard.2016.01.211 26859321 · DOI
  32. Christersson C. Thulin Å. Siegbahn A. (2017). Microparticles during long-term follow-up after acute myocardial infarction: association to atherosclerotic burden and risk of cardiovascular events. Thromb. Haemost. 117, 1571– 1581. 10.1160/TH16-11-0837 28424820 · DOI
  33. Cines D. B. McMillan R. (2005). Management of adult idiopathic thrombocytopenic purpura. Annu. Rev. Med. 56, 425– 442. 10.1146/annurev.med.56.082103.104644 15660520 · DOI
  34. Ciullo A. Biemmi V. Milano G. Bolis S. Cervio E. Fertig E. T. (2019). Exosomal expression of CXCR4 targets cardioprotective vesicles to myocardial infarction and improves outcome after systemic administration. Int. J. Mol. Sci. 20, 468. 10.3390/ijms20030468 PMC6386845 30678240 · DOI
  35. Clarke L. A. Hong Y. Eleftheriou D. Shah V. Arrigoni F. Klein N. J. (2010). Endothelial injury and repair in systemic vasculitis of the young. Arthritis Rheumatol. 62, 1770– 1780. 10.1002/art.27418 20178138 · DOI
  36. Coleman M. L. Sahai E. A. Yeo M. Bosch M. Dewar A. Olson M. F. (2001). Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat. Cell Biol. 3, 339– 345. 10.1038/35070009 11283606 · DOI
  37. Collino F. Deregibus M. C. Bruno S. Sterpone L. Aghemo G. Viltono L. (2010). Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PloS One 5, e11803. 10.1371/journal.pone.0011803 20668554 PMC2910725 · DOI · Paper page
  38. Combes V. Simon A. C. Grau G. E. Arnoux D. Camoin L. Sabatier F. (1999). In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J. Clin. Invest. 104, 93– 102. 10.1172/JCI4985 10393703 PMC408397 · DOI
  39. Connor D. E. Exner T. Ma D. D. F. Joseph J. E. (2009). Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT. Blood Coagul. Fibrinolysis 20, 558– 564. 10.1097/MBC.0b013e32832ee915 19593114 · DOI
  40. Connor D. E. Exner T. Ma D. D. F. Joseph J. E. (2010). The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb. Haemost. 103, 1044– 1052. 10.1160/TH09-09-0644 20390225 · DOI
  41. Conti L. Hiscott J. Papacchini M. Roulston A. Wainberg M. A. Belardelli F. (1997). Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages. Cell Growth Differ. 8, 435– 442. 9101089
  42. Cordazzo C. Neri T. Petrini S. Lombardi S. Balìa C. Cianchetti S. (2013). Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway. Thromb. Res. 131, e168– e174. 10.1016/j.thromres.2013.01.019 23414567 · DOI
  43. Dalli J. Serhan C. N. (2012). Specific lipid mediator signatures of human phagocytes: Microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood 120, e60– e72. 10.1182/blood-2012-04-423525 22904297 PMC3471524 · DOI
  44. Dalli J. Norling L. V. Renshaw D. Cooper D. Leung K. Y. Perretti M. (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood 112, 2512– 2519. 10.1182/blood-2008-02-140533 18594025 · DOI
  45. Dalli J. Montero-Melendez T. Norling L. V. Yin X. Hinds C. Haskard D. (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol. Cell. Proteomics 12, 2205– 2219. 10.1074/mcp.M113.028589 23660474 PMC3734580 · DOI
  46. Dalvi P. Sun B. Tang N. Pulliam L. (2017). Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Sci. Rep. 7, 9954. 10.1038/s41598-017-10449-0 28855621 PMC5577170 · DOI
  47. Daniel L. Fakhouri F. Joly D. Mouthon L. Nusbaum P. Grunfeld J.-P. (2006). Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis. Kidney Int. 69, 1416– 1423. 10.1038/sj.ki.5000306 16531979 · DOI
  48. Dasgupta S. K. Abdel-Monem H. Niravath P. Le A. Bellera R. V. Langlois K. (2009). Lactadherin and clearance of platelet-derived microvesicles. Blood 113, 1332– 1339. 10.1182/blood-2008-07-167148 19023116 PMC2637196 · DOI
  49. Davidson S. M. Riquelme J. A. Takov K. Vicencio J. M. Boi-Doku C. Khoo V. (2018a). Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro. J. Cell. Mol. Med. 22, 141– 151. 10.1111/jcmm.13302 28840975 PMC5742744 · DOI
  50. Davidson S. M. Riquelme J. A. Zheng Y. Vicencio J. M. Lavandero S. Yellon D. M. (2018b). Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning. Sci. Rep. 8, 15885. 10.1038/s41598-018-34357-z 30367147 PMC6203728 · DOI
  51. De Couto G. Liu W. Tseliou E. Sun B. Makkar N. Kanazawa H. (2015). Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction. J. Clin. Invest. 125, 3147– 3162. 10.1172/JCI81321 26214527 PMC4563759 · DOI
  52. Deatherage B. L. Cookson B. T. (2012). Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life. Infect. Immun. 80, 1948– 1957. 10.1128/IAI.06014-11 22409932 PMC3370574 · DOI
  53. Diehl K. H. Hull R. Morton D. Pfister R. Rabemampianina Y. Smith D. (2001). A good practice guide to the administration of substances and removal of blood, including routes and volumes. J. Appl. Toxicol. 21, 15– 23. 10.1002/jat.727 11180276 · DOI
  54. Diehl P. Fricke A. Sander L. Stamm J. Bassler N. Htun N. (2012). Microparticles: Major transport vehicles for distinct microRNAs in circulation. Cardiovasc. Res. 93, 633– 644. 10.1093/cvr/cvs007 22258631 PMC3291092 · DOI
  55. Dignat-George F. Boulanger C. M. (2011). The many faces of endothelial microparticles. Arterioscler. Thromb. Vasc. Biol. 31, 27– 33. 10.1161/ATVBAHA.110.218123 21160065 · DOI
  56. Doeppner T. R. Herz J. Görgens A. Schlechter J. Ludwig A.-K. Radtke S. (2015). Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl. Med. 4, 1131– 1143. 10.5966/sctm.2015-0078 26339036 PMC4572905 · DOI
  57. Duchez A.-C. Boudreau L. H. Naika G. S. Bollinger J. Belleannée C. Cloutier N. (2015). Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A 2 -IIA. Proc. Natl. Acad. Sci. 112, E3564– E3573. 10.1073/pnas.1507905112 26106157 PMC4500271 · DOI
  58. Ekström K. Omar O. Granéli C. Wang X. Vazirisani F. Thomsen P. (2013). Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells. PloS ONE 8, e75227. 10.1371/journal.pone.0075227 24058665 PMC3776724 · DOI
  59. El Andaloussi S. Mäger I. Breakefield X. O. Wood M. J. A. (2013). Extracellular vesicles: Biology and emerging therapeutic opportunities. Nat. Rev. Drug Discovery 12, 347– 357. 10.1038/nrd3978 23584393 · DOI · Paper page
  60. Elmore S. (2007). Apoptosis: A review of programmed cell death. Toxicol. Pathol. 35, 495– 516. 10.1080/01926230701320337 17562483 PMC2117903 · DOI · Paper page
  61. Erdbruegger U. Grossheim M. Hertel B. Wyss K. Kirsch T. Woywodt A. (2008). Diagnostic role of endothelial microparticles in vasculitis. Rheumatology 47, 1820– 1825. 10.1093/rheumatology/ken373 18927191 · DOI
  62. Essayagh S. Xuereb J.-M. Terrisse A.-D. Tellier-Cirioni L. Pipy B. Sié P. (2007). Microparticles from apoptotic monocytes induce transient platelet recruitment and tissue factor expression by cultured human vascular endothelial cells via a redox-sensitive mechanism. Thromb. Haemost. 98, 831– 837. 10.1160/TH07-02-0082 17938808 · DOI
  63. Faure V. Dou L. Sabatier F. Cerini C. Sampol J. Berland Y. (2006). Elevation of circulating endothelial microparticles in patients with chronic renal failure. J. Thromb. Haemost. 4, 566– 573. 10.1111/j.1538-7836.2005.01780.x 16405517 · DOI
  64. Feng B. Chen Y. Luo Y. Chen M. Li X. Ni Y. (2010). Circulating level of microparticles and their correlation with arterial elasticity and endothelium-dependent dilation in patients with type 2 diabetes mellitus. Atherosclerosis 208, 264– 269. 10.1016/j.atherosclerosis.2009.06.037 19674745 · DOI
  65. Feng Y. Huang W. Wani M. Yu X. Ashraf M. (2014). Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PloS One 9, e88685. 10.1371/journal.pone.0088685 24558412 PMC3928277 · DOI
  66. Flaumenhaft R. Mairuhu A. Italiano J. (2010). Platelet- and Megakaryocyte-Derived Microparticles. Semin. Thromb. Hemost. 36, 881– 887. 10.1055/s-0030-1267042 21049389 · DOI
  67. Fonseca P. Vardaki I. Occhionero A. Panaretakis T. (2016). “Metabolic and signaling functions of cancer cell-derived extracellular vesicles,” in. Int. Rev. Cell Mol. Biol. 326, 175– 199. 10.1016/bs.ircmb.2016.04.004 27572129 · DOI
  68. Forlow S. B. McEver R. P. Nollert M. U. (2000). Leukocyte-leukocyte interactions mediated by platelet microparticles under flow. Blood 95, 1317– 1323. 10.1182/blood.V95.4.1317.004k30_1317_1323 10666205 · DOI
  69. Furlan J. C. Fang J. Silver F. L. (2016). Outcomes after acute ischemic stroke in patients with thrombocytopenia or thrombocytosis. J. Neurol. Sci. 362, 198– 203. 10.1016/j.jns.2016.01.044 26944147 · DOI
  70. Gaetani E. Del Zompo F. Marcantoni M. Gatto I. Giarretta I. Porfidia A. (2018). Microparticles produced by activated platelets carry a potent and functionally active angiogenic signal in subjects with Crohn’s disease. Int. J. Mol. Sci. 19, 2921. 10.3390/ijms19102921 PMC6212893 30261608 · DOI
  71. Gasser O. Schifferli J. A. (2004). Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104, 2543– 2548. 10.1182/blood-2004-01-0361 15213101 · DOI
  72. Gasser O. Hess C. Miot S. Deon C. Sanchez J. C. Schifferli J. ür. A. (2003). Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp. Cell Res. 285, 243– 257. 10.1016/S0014-4827(03)00055-7 12706119 · DOI
  73. Gidlöf O. van der Brug M. öhman J. Gilje P. Olde B. Wahlestedt C. (2013). Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression. Blood 121, 3908– 3917. 10.1182/blood-2012-10-461798 23493781 · DOI
  74. Gkaliagkousi E. Passacquale G. Douma S. Zamboulis C. Ferro A. (2010). Platelet activation in essential hypertension: implications for antiplatelet treatment. Am. J. Hypertens. 23, 229– 236. 10.1038/ajh.2009.247 20094035 · DOI
  75. Goñi F. M. Alonso A. (2009). Effects of ceramide and other simple sphingolipids on membrane lateral structure. Biochim. Biophys. Acta - Biomembr. 1788, 169– 177. 10.1016/j.bbamem.2008.09.002 18848519 · DOI
  76. Goichot B. Grunebaum L. Desprez D. Vinzio S. Meyer L. Schlienger J. L. (2006). Circulating procoagulant microparticles in obesity. Diabetes Metab. 32, 82– 85. 10.1016/S1262-3636(07)70251-3 16523191 · DOI
  77. Gomez I. Ward B. Evans P. Hellewell P. Ridger V. (2015). YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna. Heart 101, A122– A123. 10.1136/heartjnl-2015-308066.225 · DOI
  78. Gomez I. Ward B. Souilhol C. Recarti C. Ariaans M. Johnston J. (2018). Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. bioRxiv 319392. 10.1101/319392 PMC6954269 31924781 · DOI
  79. Guescini M. Genedani S. Stocchi V. Agnati L. F. (2010). Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J. Neural Transm. 117, 1– 4. 10.1007/s00702-009-0288-8 19680595 · DOI
  80. Halkein J. Tabruyn S. P. Ricke-Hoch M. Haghikia A. Nguyen N. Q. N. Scherr M. (2013). MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J. Clin. Invest. 123, 2143– 2154. 10.1172/JCI64365 23619365 PMC3638905 · DOI
  81. Happonen K. E. Tran S. Mörgelin M. Prince R. Calzavarini S. Angelillo-Scherrer A. (2016). The Gas6-Axl protein interaction mediates endothelial uptake of platelet microparticles. J. Biol. Chem. 291, 10586– 10601. 10.1074/jbc.M115.699058 27006397 PMC4865908 · DOI
  82. Hargett L. A. Bauer N. N. (2013). On the origin of microparticles: from “platelet dust” to mediators of intercellular communication. Pulm. Circ. 3, 329– 340. 10.4103/2045-8932.114760 24015332 PMC3757826 · DOI
  83. Hawrylowicz C. M. (1991). Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J. Exp. Med. 174, 785– 790. 10.1084/jem.174.4.785 1680957 PMC2118954 · DOI
  84. Hay J. C. Scheller R. H. (1997). SNARES and NSF in targeted membrane fusion. Curr. Opin. Cell Biol. 9, 505– 512. 10.1016/S0955-0674(97)80026-9 9261050 · DOI
  85. Headland S. E. Norling L. V. (2015). The resolution of inflammation: principles and challenges. Semin. Immunol. 27, 149– 160. 10.1016/j.smim.2015.03.014 25911383 · DOI
  86. Headland S. E. Jones H. R. Norling L. V. Kim A. Souza P. R. Corsiero E. (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Sci. Transl. Med. 7, 315ra190– 315ra190. 10.1126/scitranslmed.aac5608 PMC6034622 26606969 · DOI
  87. Hedlund M. Stenqvist A.-C. Nagaeva O. Kjellberg L. Wulff M. Baranov V. (2009). Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: Evidence for Immunosuppressive Function. J. Immunol. 183, 340– 351. 10.4049/jimmunol.0803477 19542445 · DOI
  88. Heemskerk J. W. M. Vuist W. M. J. Feijge M. A. H. Reutelingsperger C. P. M. Lindhout T. (1997). Collagen but not fibrinogen surfaces induce Bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: Evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses. Blood 90, 2615– 2625. 10.1182/blood.V90.7.2615.2615_2615_2625 9326228 · DOI
  89. Heiss C. Amabile N. Lee A. C. Real W. M. Schick S. F. Lao D. (2008). Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function. sustained vascular injury and blunted nitric oxide production. J. Am. Coll. Cardiol. 51, 1760– 1771. 10.1016/j.jacc.2008.01.040 18452782 · DOI
  90. Hess C. Sadallah S. Hefti A. Landmann R. Schifferdi J. A. (1998). Ectosomes released by human neutrophils are specialized functional units. Mol. Immunol. 35, 354. 10.1016/s0161-5890(98)90627-7 10510400 · DOI
  91. Hessvik N. P. Øverbye A. Brech A. Torgersen M. L. Jakobsen I. S. Sandvig K. (2016). PIKfyve inhibition increases exosome release and induces secretory autophagy. Cell. Mol. Life Sci. 73, 4717– 4737. 10.1007/s00018-016-2309-8 27438886 PMC11108566 · DOI · Paper page
  92. Holvoet P. Vanhaverbeke M. Bloch K. Baatsen P. Sinnaeve P. Janssens S. (2016). Low MT-CO1 in monocytes and microvesicles is associated with outcome in patients with coronary artery disease. J. Am. Heart Assoc. 5, e004207. 10.1161/JAHA.116.004207 27919931 PMC5210432 · DOI
  93. Hong Y. Eleftheriou D. Hussain A. A. K. Price-Kuehne F. E. Savage C. O. Jayne D. (2012). Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles. J. Am. Soc Nephrol. 23, 49– 62. 10.1681/ASN.2011030298 22052057 PMC3269928 · DOI
  94. Hosseinkhani B. Kuypers S. van den Akker N. M. S. Molin D. G. M. Michiels L. (2018). Extracellular vesicles work as a functional inflammatory mediator between vascular endothelial cells and immune Cells. Front. Immunol. 9, 1789. 10.3389/fimmu.2018.01789 30131806 PMC6091278 · DOI
  95. Huber J. Vales A. Mitulovic G. Blumer M. Schmid R. Witztum J. L. (2002). Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler. Thromb. Vasc. Biol. 22, 101– 107. 10.1161/hq0102.101525 11788468 · DOI
  96. Hunter M. P. Ismail N. Zhang X. Aguda B. D. Lee E. J. Yu L. (2008). Detection of microRNA Expression in Human Peripheral Blood Microvesicles. PloS ONE 3, e3694. 10.1371/journal.pone.0003694 19002258 PMC2577891 · DOI
  97. Hyenne V. Ghoroghi S. Collot M. Bons J. Follain G. Harlepp S. (2019). Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo. Dev. Cell 48, 554– 572. e7. 10.1016/j.devcel.2019.01.014 30745140 · DOI
  98. Ishizaki T. Maekawa M. Fujisawa K. Okawa K. Iwamatsu A. Fujita A. (1996). The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15, 1885– 1893. 10.1002/j.1460-2075.1996.tb00539.x 8617235 PMC450107 · DOI
  99. Italiano J. E. Mairuhu A. T. Flaumenhaft R. (2010). Clinical relevance of microparticles from platelets and megakaryocytes. Curr. Opin. Hematol. 17, 578– 584. 10.1097/MOH.0b013e32833e77ee 20739880 PMC3082287 · DOI
  100. Janowska-Wieczorek A. Wysoczynski M. Kijowski J. Marquez-Curtis L. Machalinski B. Ratajczak J. (2005). Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int. J. Cancer 113, 752– 760. 10.1002/ijc.20657 15499615 · DOI
  101. Jansen F. Yang X. Hoyer F. F. Paul K. Heiermann N. Becher M. U. (2012). Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis. Arterioscler. Thromb. Vasc. Biol. 32, 1925– 1935. 10.1161/ATVBAHA.112.253229 22701020 · DOI
  102. Jansen F. Yang X. Hoelscher M. Cattelan A. Schmitz T. Proebsting S. (2013). Endothelial microparticle-mediated transfer of microRNA-126 promotes vascular endothelial cell repair via spred1 and is abrogated in glucose-damaged endothelial microparticles. Circulation 128, 2026– 2038. 10.1161/CIRCULATIONAHA.113.001720 24014835 · DOI
  103. Jansen F. Yang X. Proebsting S. Hoelscher M. Przybilla D. Baumann K. (2014). MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease. J. Am. Heart Assoc. 27;3 (6), e001249. 10.1161/JAHA.114.001249 PMC4338711 25349183 · DOI
  104. Jansen F. Yang X. Baumann K. Przybilla D. Schmitz T. Flender A. (2015). Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism. J. Cell. Mol. Med. 19, 2202– 2214. 10.1111/jcmm.12607 26081516 PMC4568925 · DOI
  105. Jansen F. Stumpf T. Proebsting S. Franklin B. S. Wenzel D. Pfeifer P. (2017). Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6. J. Mol. Cell. Cardiol. 104, 43– 52. 10.1016/j.yjmcc.2016.12.005 28143713 · DOI
  106. Jeppesen D. K. Fenix A. M. Franklin J. L. Higginbotham J. N. Zhang Q. Zimmerman L. J. (2019). Reassessment of exosome composition. Cell 177, 428– 445. e18. 10.1016/j.cell.2019.02.029 30951670 PMC6664447 · DOI · Paper page
  107. Jimenez J. J. Jy W. Mauro L. M. Soderland C. Horstman L. L. Ahn Y. S. (2003). Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb. Res. 109, 175– 180. 10.1016/S0049-3848(03)00064-1 12757771 · DOI
  108. Johnstone R. M. Bianchini A. Teng K. (1989). Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions. Blood 74, 1844– 1851. papers3//publication/uuid/308E8E64-F5F8-4023-A648-08B98C24F304 2790208
  109. Jung K. H. Chu K. Lee S. T. Park H. K. Bahn J. J. Kim D. H. (2009). Circulating endothelial microparticles as a marker of cerebrovascular disease. Ann. Neurol. 66, 191– 199. 10.1002/ana.21681 19743467 · DOI
  110. Kagawa H. Komiyama Y. Nakamura S. Miyake T. Miyazaki Y. Hamamoto K. (1998). Expression of functional tissue factor on small vesicles of lipopolysaccharide-stimulated human vascular endothelial cells. Thromb. Res. 91, 297– 304. 10.1016/S0049-3848(98)00108-X 9772011 · DOI
  111. Kajimoto T. Okada T. Miya S. Zhang L. Nakamura S. (2013). Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. Nat. Commun. 4, 2712. 10.1038/ncomms3712 24231649 · DOI
  112. Kanhai D. A. Visseren F. L. J. Van Der Graaf Y. Schoneveld A. H. Catanzariti L. M. Timmers L. (2013). Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease. Int. J. Cardiol. 168, 2358– 2363. 10.1016/j.ijcard.2013.01.231 23484740 · DOI
  113. Kannan M. Mohan K. V. K. Kulkarni S. Atreya C. (2009). Membrane array-based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis. Transfusion 49, 1443– 1450. 10.1111/j.1537-2995.2009.02140.x 19389023 · DOI
  114. Kanuri S. H. Ipe J. Kassab K. Gao H. Liu Y. Skaar T. C. (2018). Next generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction. Atherosclerosis 278, 232– 239. 10.1016/j.atherosclerosis.2018.09.021 30336307 PMC6350783 · DOI
  115. Khaspekova S. G. Antonova O. A. Shustova O. N. Yakushkin V. V. Golubeva N. V. Titaeva E. V. (2016). Activity of tissue factor in microparticles produced in vitro by endothelial cells, monocytes, granulocytes, and platelets. Biochem. 81, 114– 121. 10.1134/S000629791602005X 27260391 · DOI
  116. Kim H. K. Song K. S. Chung J. H. Lee K. R. Lee S. N. (2004). Platelet microparticles induce angiogenesis in vitro. Br. J. Haematol. 124, 376– 384. 10.1046/j.1365-2141.2003.04773.x 14717787 · DOI
  117. Kim S.-H. Lechman E. R. Bianco N. Menon R. Keravala A. Nash J. (2005). Exosomes derived from IL-10-Treated dendritic cells can suppress inflammation and collagen-induced arthritis. J. Immunol. 174, 6440– 6448. 10.4049/jimmunol.174.10.6440 15879146 · DOI
  118. Kim S. H. Bianco N. R. Shufesky W. J. Morelli A. E. Robbins P. D. (2007). MHC Class II + Exosomes in plasma suppress inflammation in an antigen-specific and fas ligand/fas-dependent manner. J. Immunol. 179, 2235– 2241. 10.4049/jimmunol.179.4.2235 17675484 · DOI
  119. Koga H. Sugiyama S. Kugiyama K. Watanabe K. Fukushima H. Tanaka T. (2005). Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. J. Am. Coll. Cardiol. 45, 1622– 1630. 10.1016/j.jacc.2005.02.047 15893178 · DOI
  120. Koga H. Sugiyama S. Kugiyama K. Fukushima H. Watanabe K. Sakamoto T. (2006). Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease. Eur. Heart J. 27, 817– 823. 10.1093/eurheartj/ehi746 16434416 · DOI
  121. Kuravi S. J. Harrison P. Rainger G. E. Nash G. B. (2019). Ability of platelet-derived extracellular vesicles to promote neutrophil-endothelial cell interactions. Inflammation 42, 290– 305. 10.1007/s10753-018-0893-5 30218321 PMC6394582 · DOI
  122. Lacroix R. Sabatier F. Mialhe A. Basire A. Pannell R. Borghi H. (2007). Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. Blood 110, 2432– 2439. 10.1182/blood-2007-02-069997 17606760 PMC2495018 · DOI
  123. Laffont B. Corduan A. Plé H. Duchez A.-C. Cloutier N. Boilard E. (2013). Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles. Blood 122, 253– 261. 10.1182/blood-2013-03-492801 23652806 · DOI
  124. Laffont B. Corduan A. Rousseau M. Duchez A. C. Lee C. H. C. Boilard E. (2016). Platelet microparticles reprogram macrophage gene expression and function. Thromb. Haemost. 115, 311– 323. 10.1160/TH15-05-0389 26333874 · DOI
  125. Lai R. C. Arslan F. Lee M. M. Sze N. S. K. Choo A. Chen T. S. (2010). Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 4, 214– 222. 10.1016/j.scr.2009.12.003 20138817 · DOI · Paper page
  126. Landry P. Plante I. Ouellet D. L. Perron M. P. Rousseau G. Provost P. (2009). Existence of a microRNA pathway in anucleate platelets. Nat. Struct. Mol. Biol. 16, 961– 966. 10.1038/nsmb.1651 19668211 PMC2911476 · DOI
  127. Lee Y. J. Jy W. Horstman L. L. Janania J. Reyes Y. Kelley R. E. (1993). Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias. Thromb. Res. 72, 295– 304. 10.1016/0049-3848(93)90138-E 8303669 · DOI
  128. Leung T. Chen X. Q. Manser E. Lim L. (1996). The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16, 5313– 5327. 10.1128/mcb.16.10.5313 8816443 PMC231530 · DOI
  129. Li B. Antonyak M. A. Zhang J. Cerione R. A. (2012a). RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene 31, 4740– 4749. 10.1038/onc.2011.636 22266864 PMC3607381 · DOI
  130. Li X. Li J.-J. Yang J.-Y. Wang D.-S. Zhao W. Song W.-J. (2012b). Tolerance induction by exosomes from immature dendritic cells and rapamycin in a mouse cardiac allograft model. PloS One 7, e44045. 10.1371/journal.pone.0044045 22952868 PMC3430614 · DOI
  131. Li J. Zhang Y. Liu Y. Dai X. Li W. Cai X. (2013a). Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis. J. Biol. Chem. 288, 23586– 23596. 10.1074/jbc.M113.489302 23766514 PMC3949332 · DOI
  132. Li J. Zhang Y. Liu Y. Dai X. Li W. Cai X. (2013b). Microvesicle-mediated transfer of MicroRNA-150 from monocytes to endothelial cells promotes angiogenesis. J. Biol. Chem. 288, 23586– 23596. 10.1074/jbc.M113.489302 23766514 PMC3949332 · DOI
  133. Li M. Zhang X. Yu J. Wu X. Sun L. (2017). Monocyte-derived procoagulant microvesicles induced by high glucose can be attenuated by the antioxidant N-Acetyl-L-Cysteine, partly through the P38/MAPK pathway. Metab. Syndr. Relat. Disord. 15, 521– 526. 10.1089/met.2017.0089 29125808 · DOI
  134. Lim K. Sumagin R. Hyun Y.-M. (2013). Extravasating neutrophil-derived microparticles preserve vascular barrier function in inflamed tissue. Immune Netw. 13, 102. 10.4110/in.2013.13.3.102 23885224 PMC3718920 · DOI
  135. Lindemann S. Tolley N. D. Dixon D. A. McIntyre T. M. Prescott S. M. Zimmerman G. A. (2001). Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis. J. Cell Biol. 154, 485– 490. 10.1083/jcb.200105058 11489912 PMC2196422 · DOI
  136. Lorincz A. M. Schutte M. Timar C. I. Veres D. S. Kittel A. McLeish K. R. (2015). Functionally and morphologically distinct populations of extracellular vesicles produced by human neutrophilic granulocytes. J. Leukoc. Biol. 98, 583– 589. 10.1189/jlb.3vma1014-514r 25986013 · DOI
  137. Ludwig A. K. Giebel B. (2012). Exosomes: small vesicles participating in intercellular communication. Int. J. Biochem. Cell Biol. 44, 11– 15. 10.1016/j.biocel.2011.10.005 22024155 · DOI
  138. Luther K. M. Haar L. McGuinness M. Wang Y. Lynch T. Phan A. (2018). Exosomal miR-21a-5p mediates cardioprotection by mesenchymal stem cells. J. Mol. Cell. Cardiol. 119, 125– 137. 10.1016/j.yjmcc.2018.04.012 29698635 · DOI
  139. Ma X. Becker Buscaglia L. E. Barker J. R. Li Y. (2011). MicroRNAs in NF- B signaling. J. Mol. Cell Biol. 3, 159– 166. 10.1093/jmcb/mjr007 21502305 PMC3104013 · DOI
  140. Mack M. Kleinschmidt A. Brühl H. Klier C. Nelson P. J. Cihak J. (2000). Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection. Nat. Med. 6, 769– 775. 10.1038/77498 10888925 · DOI
  141. MacKie A. R. Klyachko E. Thorne T. Schultz K. M. Millay M. Ito A. (2012). Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction. Circ. Res. 111, 312– 321. 10.1161/CIRCRESAHA.112.266015 22581926 PMC3511820 · DOI
  142. Majka M. Kijowski J. Lesko E. Zupanska B. Ratajczak M. Z. (2007). Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/progenitor cells - Implication for the pathogenesis of immune thrombocytopenias. Folia Histochem. Cytobiol. 45, 27– 32. 17378242
  143. Maki M. Takahara T. Shibata H. (2016). Multifaceted roles of ALG-2 in Ca2+-regulated membrane trafficking. Int. J. Mol. Sci. 17, 1401. 10.3390/ijms17091401 PMC5037681 27571067 · DOI
  144. Marrachelli V. G. Mastronardi M. L. Sarr M. Soleti R. Leonetti D. Martínez M. C. (2013). Sonic hedgehog carried by microparticles corrects angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice. PloS One 8, e72861. 10.1371/journal.pone.0072861 23977364 PMC3745429 · DOI
  145. Mastronardi M. L. Mostefai H. A. Soleti R. Agouni A. Martínez M. C. Andriantsitohaina R. (2011). Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells. Fundam. Clin. Pharmacol. 25, 653– 660. 10.1111/j.1472-8206.2010.00898.x 21105910 · DOI
  146. Matsui T. Amano M. Yamamoto T. Chihara K. Nakafuku M. Ito M. (1996). Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 15, 2208– 2216. 10.1002/j.1460-2075.1996.tb00574.x 8641286 PMC450144 · DOI
  147. Mause S. F. Von Hundelshausen P. Zernecke A. Koenen R. R. Weber C. (2005). Platelet microparticles: A transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler. Thromb. Vasc. Biol. 25, 1512– 1518. 10.1161/01.ATV.0000170133.43608.37 15890969 · DOI
  148. Mayourian J. Ceholski D. K. Gorski P. A. Mathiyalagan P. Murphy J. F. Salazar S. I. (2018). Exosomal microRNA-21-5p mediates mesenchymal stem cell paracrine effects on human cardiac tissue contractility. Circ. Res. 122, 933– 944. 10.1161/CIRCRESAHA.118.312420 29449318 PMC5986183 · DOI
  149. Mesri M. Altieri D. C. (1998). Endothelial cell activation by leukocyte microparticles. J. Immunol. 161, 4382– 4387. 9780216
  150. Mitra S. Wewers M. D. Sarkar A. (2015). Mononuclear phagocyte-derived microparticulate Caspase-1 induces pulmonary vascular endothelial cell injury. PloS One 10, e0145607. 10.1371/journal.pone.0145607 26710067 PMC4692444 · DOI
  151. Morel O. Toti F. Hugel B. Bakouboula B. Camoin-Jau L. Dignat-George F. (2006). Procoagulant Microparticles. Arterioscler. Thromb. Vasc. Biol. 26, 2594– 2604. 10.1161/01.ATV.0000246775.14471.26 16990554 · DOI
  152. Morel O. Ohlmann P. Epailly E. Bakouboula B. Zobairi F. Jesel L. (2008). Endothelial cell activation contributes to the release of procoagulant microparticles during acute cardiac allograft rejection. J. Hear. Lung Transplant. 27, 38– 45. 10.1016/j.healun.2007.09.031 18187085 · DOI
  153. Morel O. Toti F. Morel N. Freyssinet J.-M. (2009). Microparticles in endothelial cell and vascular homeostasis: are they really noxious? Haematologica 94, 313– 317. 10.3324/haematol.2009.003657 19252173 PMC2649364 · DOI
  154. Mostefai H. A. Meziani F. Mastronardi M. L. Agouni A. Heymes C. Sargentini C. (2008). Circulating microparticles from patients with septic shock exert protective role in vascular function. Am. J. Respir. Crit. Care Med. 178, 1148– 1155. 10.1164/rccm.200712-1835OC 18723433 · DOI
  155. Nadkarni S. Lashin H. Hollywood J. Dasgupta B. Mason J. C. Perretti M. (2019). Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: A potential involvement of immune cell cross-talk. Clin. Sci. 133, 839– 851. 10.1042/CS20180415 30898854 PMC6449535 · DOI
  156. Nazari-Jahantigh M. Wei Y. Noels H. Akhtar S. Zhou Z. Koenen R. R. (2012). MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J. Clin. Invest. 122, 4190– 4202. 10.1172/JCI61716 23041630 PMC3484435 · DOI
  157. Ng Y. H. Rome S. Jalabert A. Forterre A. Singh H. Hincks C. L. (2013). Endometrial exosomes/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation. PloS One 8, e58502. 10.1371/journal.pone.0058502 23516492 PMC3596344 · DOI
  158. Nguyen M.-A. Karunakaran D. Geoffrion M. Cheng H. S. Tandoc K. Perisic Matic L. (2018). Extracellular vesicles secreted by atherogenic macrophages transfer MicroRNA to inhibit cell migration. Arterioscler. Thromb. Vasc. Biol. 38, 49– 63. 10.1161/ATVBAHA.117.309795 28882869 PMC5884694 · DOI
  159. Njock M. S. Cheng H. S. Dang L. T. Nazari-Jahantigh M. Lau A. C. Boudreau E. (2015). Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood 125, 3202– 3212. 10.1182/blood-2014-11-611046 25838349 PMC4440888 · DOI
  160. Nomura S. Suzuki M. Katsura K. Xie G. L. Miyazaki Y. Miyake T. (1995). Platelet-derived microparticles may influence the development of atherosclerosis in diabetes mellitus. Atherosclerosis 116, 235– 240. 10.1016/0021-9150(95)05551-7 7575778 · DOI
  161. Nomura S. Shouzu A. Omoto S. Nishikawa M. Iwasaka T. Fukuhara S. (2004). Activated platelet and oxidized LDL induce endothelial membrane vesiculation: clinical significance of endothelial cell-derived microparticles in patients with type 2 diabetes. Clin. Appl. Thromb. 10, 205– 215. 10.1177/107602960401000302 15247977 · DOI
  162. Nomura S. (2001). High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis 158, 277– 287. 10.1016/S0021-9150(01)00433-6 11583705 · DOI
  163. Norling L. V. Spite M. Yang R. Flower R. J. Perretti M. Serhan C. N. (2011). Cutting edge: humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J. Immunol. 186, 5543– 5547. 10.4049/jimmunol.1003865 21460209 PMC3145138 · DOI
  164. Odintsova E. Van Niel G. Conjeaud H. Raposo G. Iwamoto R. Mekada E. (2013). Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor. J. Biol. Chem. 288, 26323– 26334. 10.1074/jbc.M112.439380 23897813 PMC3764837 · DOI
  165. Ong S. G. Lee W. H. Huang M. Dey D. Kodo K. Sanchez-Freire V. (2014). Cross talk of combined gene and cell therapy in ischemic heart disease role of exosomal MicroRNA transfer. Circulation 130, S60– S69. 10.1161/CIRCULATIONAHA.113.007917 25200057 PMC4862832 · DOI
  166. Ou Z. J. Chang F. J. Luo D. Liao X. L. Wang Z. P. Zhang X. (2011). Endothelium-derived microparticles inhibit angiogenesis in the heart and enhance the inhibitory effects of hypercholesterolemia on angiogenesis. Am. J. Physiol. - Endocrinol. Metab. 300, 661– 668. 10.1152/ajpendo.00611.2010 21245463 · DOI
  167. Owens A. P. Mackman N. (2011). Microparticles in Hemostasis and Thrombosis. Circ. Res. 108, 1284– 1297. 10.1161/CIRCRESAHA.110.233056 21566224 PMC3144708 · DOI
  168. Pérez-Casal M. Downey C. Cutillas-Moreno B. Zuzel M. Fukudome K. Ton C. H. (2009). Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects. Haematologica 94, 387– 394. 10.3324/haematol.13547 19211643 PMC2649352 · DOI
  169. Pan Y. Liang H. Liu H. Li D. Chen X. Li L. (2014). platelet-secreted MicroRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor. J. Immunol. 192, 437– 446. 10.4049/jimmunol.1301790 24307738 · DOI
  170. Pasquet J.-M. Dachary-Prigent J. Nurden A. T. (1998). Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagen. Biochem. J. 333, 591– 599. 10.1042/bj3330591 9677317 PMC1219621 · DOI
  171. Perez-Pujol S. Marker P. H. Key N. S. (2007). Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytom. Part A 71A, 38– 45. 10.1002/cyto.a.20354 17216623 · DOI
  172. Peterson D. B. Sander T. Kaul S. Wakim B. T. Halligan B. Twigger S. (2008). Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. Proteomics 8, 2430– 2446. 10.1002/pmic.200701029 18563738 PMC4753841 · DOI
  173. Pfrieger F. W. Vitale N. (2018). Cholesterol and the journey of extracellular vesicles. J. Lipid Res. 59, 2255– 2261. 10.1194/jlr.R084210 29678958 PMC6277151 · DOI
  174. Pierce G. F. (1989). Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J. Cell Biol. 109, 429– 440. 10.1083/jcb.109.1.429 2745556 PMC2115493 · DOI
  175. Pinto S. M. Nirujogi R. S. Rojas P. L. Patil A. H. Manda S. S. Subbannayya Y. (2015). Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532– 544. 10.1002/pmic.201400303 25367039 PMC4528959 · DOI
  176. Preston R. A. Jy W. Jimenez J. J. Mauro L. M. Horstman L. L. Valle M. (2003). Effects of severe hypertension on endothelial and platelet microparticles. Hypertension 41, 211– 217. 10.1161/01.HYP.0000049760.15764.2D 12574084 · DOI
  177. Rauschenberger L. Staar D. Thom K. Scharf C. Venz S. Homuth G. (2016). Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment. Prostate 76, 409– 424. 10.1002/pros.23132 26643154 · DOI
  178. Rectenwald J. E. Myers D. D. Hawley A. E. Longo C. Henke P. K. Guire K. E. (2005). D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis: a pilot study. Thromb. Haemost. 94, 1312– 1317. 10.1160/TH05-06-0426 16411411 · DOI
  179. Rhys H. I. Dell’ Accio F. Pitzalis C. Moore A. Norling L. V. Perretti M. (2018). Neutrophil microvesicles from healthy control and rheumatoid arthritis patients prevent the inflammatory activation of macrophages. EBioMedicine 29, 60– 69. 10.1016/j.ebiom.2018.02.003 29449195 PMC5925578 · DOI
  180. Ridger V. C. Boulanger C. M. Angelillo-Scherrer A. Badimon L. Blanc-Brude O. Bochaton-Piallat M. L. (2017). Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology. Thromb. Haemost. 117, 1296– 1316. 10.1160/TH16-12-0943 28569921 · DOI
  181. Ross R. (1986). The pathogenesis of atherosclerosis — an update. N. Engl. J. Med. 314, 488– 500. 10.1056/NEJM198602203140806 3511384 · DOI
  182. Sáez T. de Vos P. Kuipers J. Sobrevia L. Faas M. M. (2019). Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions. Immunobiology 224, 325– 333. 10.1016/j.imbio.2019.02.004 30827721 · DOI
  183. Sabatier F. Roux V. Anfosso F. Camoin L. Sampol J. Dignat-George F. (2002). Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor–dependent procoagulant activity. Blood 99, 3962– 3970. 10.1182/blood.V99.11.3962 12010795 · DOI
  184. Sadallah S. Amicarella F. Eken C. Iezzi G. Schifferli J. (2014). Ectosomes released by platelets induce differentiation of CD4+ T cells into T regulatory cells. Thromb. Haemost. 112, 1219– 1229. 10.1160/th14-03-0281 25209750 · DOI
  185. Sarkar A. Mitra S. Mehta S. Raices R. Wewers M. D. (2009). Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PloS One 4, e7140. 10.1371/journal.pone.0007140 19779610 PMC2744928 · DOI
  186. Shet A. S. Aras O. Gupta K. Hass M. J. Rausch D. J. Saba N. (2003). Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood 102, 2678– 2683. 10.1182/blood-2003-03-0693 12805058 · DOI
  187. Shimazu T. Inami N. Satoh D. Kajiura T. Yamada K. Iwasaka T. (2009). Effect of acarbose on platelet-derived microparticles, soluble selectins, and adiponectin in diabetic patients. J. Thromb. Thrombolysis 28, 429– 435. 10.1007/s11239-008-0301-3 19137265 · DOI
  188. Shustova O. N. Antonova O. A. Golubeva N. V. Khaspekova S. G. Yakushkin V. V. Aksuk S. A. (2017). Differential procoagulant activity of microparticles derived from monocytes, granulocytes, platelets and endothelial cells: impact of active tissue factor. Blood Coagul. Fibrinolysis 28, 373– 382. 10.1097/MBC.0000000000000609 27926582 · DOI
  189. Šimák J. Holada K. Vostal J. G. (2002). Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin. BMC Cell Biol. 3, 11. 10.1186/1471-2121-3-11 12052248 PMC116580 · DOI
  190. Stehouwer C. D. A. Henry R. M. A. Ferreira I. (2008). Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia 51, 527– 539. 10.1007/s00125-007-0918-3 18239908 · DOI
  191. Steogonekpień E. Stankiewicz E. Zalewski J. Godlewski J. Zmudka K. Wybrańska I. (2012). Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation. Arch. Med. Res. 43, 31– 35. 10.1016/j.arcmed.2012.01.006 22306248 · DOI
  192. Stojkovic S. Thulin Å. Hell L. Thaler B. Rauscher S. Baumgartner J. (2017). IL-33 stimulates the release of procoagulant microvesicles from human monocytes and differentially increases tissue factor in human monocyte subsets. Thromb. Haemost. 117, 1379– 1390. 10.1160/TH16-10-0784 28492698 · DOI
  193. Stuffers S. Sem Wegner C. Stenmark H. Brech A. (2009). Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 10, 925– 937. 10.1111/j.1600-0854.2009.00920.x 19490536 · DOI
  194. Suades R. Padró T. Vilahur G. Badimon L. (2012). Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques. Thromb. Haemost. 108, 1208– 1219. 10.1160/TH12-07-0486 23138460 · DOI
  195. Sugimoto M. A. Sousa L. P. Pinho V. Perretti M. Teixeira M. M. (2016). Resolution of inflammation: what controls its onset? Front. Immunol. 7, 160. 10.3389/fimmu.2016.00160 27199985 PMC4845539 · DOI · Paper page
  196. Sun C. Feng S.-B. Cao Z.-W. Bei J.-J. Chen Q. Zhao W.-B. (2017). Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell. Physiol. Biochem. 41, 2319– 2332. 10.1159/000475651 28463834 · DOI
  197. Suzuki J. Umeda M. Sims P. J. Nagata S. (2010). Calcium-dependent phospholipid scrambling by TMEM16F. Nature 468, 834– 840. 10.1038/nature09583 21107324 · DOI
  198. Szotowski B. Antoniak S. Goldin-Lang P. Tran Q. V. Pels K. Rosenthal P. (2007). Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells. Cardiovasc. Res. 73, 806– 812. 10.1016/j.cardiores.2006.12.018 17266944 · DOI
  199. Tamai K. Tanaka N. Nakano T. Kakazu E. Kondo Y. Inoue J. (2010). Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem. Biophys. Res. Commun. 399, 384– 390. 10.1016/j.bbrc.2010.07.083 20673754 · DOI
  200. Tang N. Sun B. Gupta A. Rempel H. Pulliam L. (2016). Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells. FASEB J. 30, 3097– 3106. 10.1096/fj.201600368RR 27226520 PMC5001509 · DOI

200 of 232 shown

Cited by

Sorted by citations

Authors
Oggero, S., Austin-Williams, S., & Norling, L. V.
Affiliations
Queen Mary University of London (GB)
Corresponding author
Norling, Lucy Victoria
ORCID
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2019-12-17
Volume
10
Pages
1479-1479
ISSN
1663-9812 (ISSN-L)
DOI
10.3389/fphar.2019.01479
PMC
PMC6928593
OpenAlex
W2996620173
Cited by
85
References
4
Citations by year
2026: 6 · 2025: 4 · 2024: 4 · 2023: 12 · 2022: 15 · 2021: 30 · 2020: 13 · 2018: 1
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
Funders
  • Versus Arthritis (22235, 21941)
  • H2020 Marie Skłodowska-Curie Actions (675111)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
extracellular vesicles, vascular inflammation, tissue repair, endothelium, platelet-derived extracellular vesicles, endothelial cells, vascular smooth muscle cells, intercellular communication, inflammation resolution, vascular repair, cardiovascular disease, biomarkers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review