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Cited by 129Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Testosterone and Regional Fat Distribution

Open access
Mårin, Per·1995·Obesity Research
DOI 10.1002/j.1550-8528.1995.tb00233.x
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Abstract

The effects of testosterone treatment of abdominally obese men have been assessed by evaluating the following parameters: The metabolic activity of different adipose tissue regions in vivo (using lipid label as a tracer) and in vitro (measuring lipoprotein lipase (LPL) activity), the total and visceral adipose tissue mass, insulin sensitivity, fasting blood glucose, blood lipids, and blood pressure as well as prostate volume. Middle-aged men with abdominal obesity were treated with transdermal administration of testosterone (T), dihydrotestosterone (DHT) or placebo (P) during 9 months. The study was double-blind. Treatment with T was followed by an inhibited uptake of lipid label in adipose tissue triglycerides, a decreased LPL-activity and an increased turn-over rate of lipid label in the abdominal adipose tissue region in comparisons with the DHT and P groups. These effects on adipose tissue metabolism were not detected in the femoral adipose tissue region in any of the groups. T treatment was also followed by a specific decrease of visceral fat mass (measured by CT-scan), by increased insulin sensitivity (measured with the euglycemic glucose clamp), by a decrease in fasting blood glucose, plasma cholesterol and triglycerides as well as a decrease in diastolic blood pressure. In the DHT group an increased visceral mass was detected. No other changes in these variables were found in the DHT and P groups. There were no detectable changes in prostate volume (measured by ultra-sound), prostate specific antigen concentration, genito-urinary history or urinary flow measurements in any of the groups. It is suggested that T substitution to a selected group of men results in general metabolic and circulatory improvements. The prostate area needs further careful attention.

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Crossref · 10.1002/j.1550-8528.1995.tb00233.x

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Research works printed but not linked: 5

  1. Arvidsson B., 1972, Clinical application of a high‐sensitivity whole body counter, Digest of the Third International Conference on Medical Physics Including Medical Engineering., 41, 2
  2. Mårin P., 1992, Androgen treatment of middle‐aged, obese men ‐ effects on metabolism, muscle and adipose tissue, Eur J Intern Med., 1, 329
  3. 10.1210/jc.80.1.239 · DOI · Paper page
  4. 10.1210/jc.77.2.341 · DOI · Paper page
  5. WHO, 1988, Measuring obesity; classification and description of anthropometric data, 1

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Metadata

Authors
Mårin, P.
Affiliations
Sahlgrenska University Hospital (SE)
Corresponding author
Mårin, Per
Venue
Obesity Research
Publisher
Wiley
Published
1995-11
Volume
3
Issue
S4
Pages
609S-612S
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1002/j.1550-8528.1995.tb00233.x
OpenAlex
W2071063544
Cited by
129
References
22
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
0.26
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6154 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
testosterone, dihydrotestosterone, abdominal obesity, visceral fat, adipose tissue metabolism, lipoprotein lipase, insulin sensitivity, serum lipids, blood pressure, prostate volume, transdermal testosterone
MeSH terms
Adipose Tissue, Body Constitution, Double-Blind Method, Humans, Male, Middle Aged, Obesity, Dihydrotestosterone, Testosterone, Triglycerides, Lipid Metabolism

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