Cited by 129Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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Testosterone and Regional Fat Distribution

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Mårin, Per·1995·Obesity Research

DOI 10.1002/j.1550-8528.1995.tb00233.x

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Abstract

The effects of testosterone treatment of abdominally obese men have been assessed by evaluating the following parameters: The metabolic activity of different adipose tissue regions in vivo (using lipid label as a tracer) and in vitro (measuring lipoprotein lipase (LPL) activity), the total and visceral adipose tissue mass, insulin sensitivity, fasting blood glucose, blood lipids, and blood pressure as well as prostate volume. Middle-aged men with abdominal obesity were treated with transdermal administration of testosterone (T), dihydrotestosterone (DHT) or placebo (P) during 9 months. The study was double-blind. Treatment with T was followed by an inhibited uptake of lipid label in adipose tissue triglycerides, a decreased LPL-activity and an increased turn-over rate of lipid label in the abdominal adipose tissue region in comparisons with the DHT and P groups. These effects on adipose tissue metabolism were not detected in the femoral adipose tissue region in any of the groups. T treatment was also followed by a specific decrease of visceral fat mass (measured by CT-scan), by increased insulin sensitivity (measured with the euglycemic glucose clamp), by a decrease in fasting blood glucose, plasma cholesterol and triglycerides as well as a decrease in diastolic blood pressure. In the DHT group an increased visceral mass was detected. No other changes in these variables were found in the DHT and P groups. There were no detectable changes in prostate volume (measured by ultra-sound), prostate specific antigen concentration, genito-urinary history or urinary flow measurements in any of the groups. It is suggested that T substitution to a selected group of men results in general metabolic and circulatory improvements. The prostate area needs further careful attention.

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Authors: Mårin, P.
Affiliations: Sahlgrenska University Hospital (SE)
Corresponding author: Mårin, Per
Venue: Obesity Research
Publisher: Wiley
Published: 1995-11
Volume: 3
Issue: S4
Pages: 609S-612S
ISSN: 1071-7323 (ISSN-L)
1550-8528
DOI: 10.1002/j.1550-8528.1995.tb00233.x
OpenAlex: W2071063544
Cited by: 129
References: 22
Citations by year: 2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
FWCI: 0.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6154 d)
Locations: Obesity Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: testosterone, dihydrotestosterone, abdominal obesity, visceral fat, adipose tissue metabolism, lipoprotein lipase, insulin sensitivity, serum lipids, blood pressure, prostate volume, transdermal testosterone
MeSH terms: Adipose Tissue, Body Constitution, Double-Blind Method, Humans, Male, Middle Aged, Obesity, Dihydrotestosterone, Testosterone, Triglycerides, Lipid Metabolism

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