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Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level
Open accessAbstract
Physical disorders are, compared to the general population, more prevalent in people with severe mental illness (SMI). Although this excess morbidity and mortality is largely due to modifiable lifestyle risk factors, the screening and assessment of physical health aspects remains poor, even in developed countries. Moreover, specific patient, provider, treatment and system factors act as barriers to the recognition and to the management of physical diseases in people with SMI. Psychiatrists can play a pivotal role in the improvement of the physical health of these patients by expanding their task from clinical psychiatric care to the monitoring and treatment of crucial physical parameters. At a system level, actions are not easy to realize, especially for developing countries. However, at an individual level, even simple and very basic monitoring and treatment actions, undertaken by the treating clinician, can already improve the problem of suboptimal medical care in this population. Adhering to monitoring and treatment guidelines will result in a substantial enhancement of physical health outcomes. Furthermore, psychiatrists can help educate and motivate people with SMI to address their suboptimal lifestyle, including smoking, unhealthy diet and lack of exercise. The adoption of the recommendations presented in this paper across health care systems throughout the world will contribute to a significant improvement in the medical and related psychiatric health outcomes of patients with SMI.
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“Professional barriers to screening within mental health settings may in their turn reflect lack of clarity about whose clinical responsibility the screening is, lack of understanding about what should be measured and when, uncertainity about how to interpret results, and lack of access to necessary equipment 41 , as well as incomplete communication between primary and secondary care.”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [41]
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Moteshafi, H., & Stip, É. (2012) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2012.712682 · Cited by 20
“The SGAs side effects on physical health have become an important issue in mental illnesses’ treatment [20].”
BackgroundMadan, A., Clapp, J. D., Osborne, P. J., Walker, C. R., Frueh, B. C., Allen, J. G., Oldham, J. M., & Fowler, J. C. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000298 · Cited by 20
“, smoking), psychotropic medications, psychiatric symptoms, and disparities in access to and receipt of health care in general (17).”
Backgroundİnce, S. Ç., Günüşen, N. P., & Serçe, Ö. (2018) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/jpm.12456 · Cited by 20
Oral Health Is a Challenging Problem for Patients with Schizophrenia: A Narrative Review
Denis, F., Pelletier, J., Chauvet‐Gélinier, J., Rude, N., & Trojak, B. (2018) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.8062 · Cited by 20
“In response to the increase in chronic diseases, the very high rate of treatment non-observance and the need for more patient autonomy, the partner patient concept is gradually emerging as a healthcare approach (35-54).”
BackgroundBlomqvist, M., Ivarsson, A., Carlsson, I., Sandgren, A., & Jormfeldt, H. (2019) · Issues in Mental Health Nursing · doi:10.1080/01612840.2019.1642425 · Cited by 22
Vancampfort, D., Holt, R. I. G., Stubbs, B., Binder, M. D., Samaras, K., & Mitchell, A. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803376-0.00012-5 · Cited by 21
Nguyen, T., Faulkner, D., Frayne, J. S., Allen, S., Hauck, Y. L., Rock, D., & Rampono, J. (2012) · MJA Open · doi:10.5694/mjao11.11152 · Cited by 20
Mental disorder recovery correlated with centralities and interactions on an online social network
Ma, X., & Sayama, H. (2015) · PeerJ · doi:10.7717/peerj.1163 · Cited by 19
“…be found on page 12 DOI 10.7717/peerj.1163 Copyright 2015 Ma and Sayama Distributed under Creative Commons CC-BY 4.0 OPEN ACCESS Subjects Psychiatry and Psychology, Public Health Keywords Social media, Mental disorder, Social network, Patient-to-patient network, PatientsLikeMe, Non-drug treatments”
BackgroundInfluentialKarow, A., Brettschneider, C., König, H. ‐., Correll, C. U., Schöttle, D., Lüdecke, D., Rohenkohl, A. C., Ruppelt, F., Kraft, V., Gallinat, J., et al. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13139 · Cited by 19
Self-citationGühne, U., Pabst, A., Kösters, M., Hasan, A., Falkai, P., Kilian, R., Allgöwer, A., Ajayi, K., Baumgärtner, J., Brieger, P., et al. (2022) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-022-00345-3 · Cited by 19
“Other approaches have also been developed to improve physical health in Individuals with SMI, such as promoting smoking cessation, physical health monitoring and changes in healthcare organization [58, 59].”
BackgroundKnudsen, L., Scheuer, S. H., Díaz, L. J., Jackson, C., Wild, S. H., Benros, M. E., Hansen, D. L., Jørgensen, M. E., & Andersen, G. S. (2022) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2022.100565 · Cited by 19
Risk factors for poor COVID-19 outcomes in patients with psychiatric disorders
Cheng, W., Shih, H.-M., Su, K., & Hsueh, P. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.024 · Cited by 21
Mugisha, J., Binder, M. D., Stubbs, B., Basangwa, D., & Vancampfort, D. (2017) · International Journal of Mental Health Systems · doi:10.1186/s13033-017-0141-7 · Cited by 21
“The metabolic risk associated with antipsychotics has led to the development of several International treatment guidelines for routine metabolic screening and monitoring in patients taking antipsychotic medication [11, 12].”
BackgroundIkonen, H., Palaniswamy, S., Nordström, T., Järvelin, M., Herzig, K., Jääskeläinen, E., Seppälä, J., Miettunen, J., & Sebert, S. P. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.060 · Cited by 19
Barcella, C. A., Mohr, G. H., Kragholm, K. H., Gerds, T. A., Jensen, S. E., Polcwiartek, C., Wissenberg, M., Lippert, F. K., Torp-Pedersen, C. T., Kessing, L. V., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012708 · Cited by 19
Holingue, C., Kalb, L. G., Klein, A., & Beasley, J. B. (2020) · Intellectual and developmental disabilities · doi:10.1352/1934-9556-58.5.379 · Cited by 19
Steylen, P., der Heijden, F. M. M. A. V., Kok, H., Sijben, N., & Verhoeven, W. M. A. (2013) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2013.779000 · Cited by 17
Severe mental illness diagnosis in English general hospitals 2006-2017: A registry linkage study
Mansour, H., Mueller, C., Davis, K. A. S., Burton, A., Shetty, H., Hotopf, M. H., Osborn, D., Stewart, R. J., & Sommerlad, A. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003306 · Cited by 18
“Patient-level factors include language barriers, lack of information disclosure, or distrust of clinicians from different backgrounds, and service-level factors include clinician bias, stigma, or lack of cultural awareness [38].”
BackgroundPhysical symptoms as psychiatric manifestations in medical spaces: A qualitative study
Spurrier, G. F., Shulman, K. S., Dibich, S., Benoit, L., Duckworth, K. S., & Martin, A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1074424 · Cited by 18
“To tackle these physical health disparities in patients with mental illness, several prior pieces of literature have suggested more integrated and collaborative health care (4, 5, 14, 17, 35).”
BackgroundLakbar, I., Léone, M., Pauly, V., Orléans, V., Srougbo, K. J., Diao, S., Llorca, P., Solmi, M., Correll, C. U., Fernandes, S., et al. (2023) · PLoS Medicine · doi:10.1371/journal.pmed.1004202 · Cited by 18
“Among somatic diseases, infections are disproportionately more frequent in patients with SMI than in the general population, representing a potentially avoidable contributor to early death [2,7,8].”
BackgroundSelf-citationvan Meijel, B., van Hamersveld, S., van Gool, R., van der Bijl, J., & van Harten, P. N. (2014) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12071 · Cited by 18
“Psychiatrists (De Hert et al., 2009, 2011a; Marder et al., 2004) and mental health nurses (Brunero & Lamont, 2009; Ohlsen, Peacock, & Smith, 2005; Shuel, White, Jones, & Gray, 2010; Usher, Foster, & Park, 2006) have developed a number of guidelines and tools aimed at better screening and monitoring…”
Cranwell, K., Polacsek, M., & McCann, T. V. (2016) · International Journal of Mental Health Nursing · doi:10.1111/inm.12174 · Cited by 18
“Third, poor access to primary and tertiary medical care; concern about the quality of care, including underdiagnosis and inadequate screening; assessment and treatment of serious illnesses (De Hert et al .”
Measurement of Metabolic Monitoring in Youth and Adult Medicaid Recipients Prescribed Antipsychotics
Edelsohn, G. A., Parthasarathy, M., Terhorst, L. A., Karpov, I. O., & Schuster, J. (2015) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2015.21.9.769 · Cited by 21
Physical health status of older adults with severe mental illness: The PH i SMI ‐E cohort study
Houben, N., Janssen, E. P. C. J., Hendriks, M. R., van der Kellen, D., van Alphen, B., & van Meijel, B. (2018) · International Journal of Mental Health Nursing · doi:10.1111/inm.12547 · Cited by 18
de Caluwé, L., van Buitenen, N., Gelan, P., Crunelle, C., Thomas, R., Casseres, S., Matthys, F., Harten, P., & Cahn, W. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112558 · Cited by 15
HIV infection and its psychiatric manifestations:A clinical overview
Knights, M. J., Chatziagorakis, A., & Kumar Buggineni, S. (2017) · BJPsych Advances · doi:10.1192/apt.bp.116.016311 · Cited by 18
Patino, L. R., Strawn, J. R., Adler, C. M., Blom, T. J., Welge, J. A., & DelBello, M. P. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.04.046 · Cited by 18
Gentil, L., Grenier, G., Meng, X., & Fleury, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.735005 · Cited by 17
“Other studies reported that patients with MD-CPI were less likely than others to receive care for CPI from their GP (61, 62), suggesting that they may have used psychiatric ED for medical issues.”
BackgroundCosta, R., Teasdale, S. B., Abreu, S., Bastos, T. C. L., Probst, M., Rosenbaum, S., Ward, P. B., & Corredeira, R. (2019) · Issues in Mental Health Nursing · doi:10.1080/01612840.2019.1642426 · Cited by 17
“Anthropometric characteristics revealed that only a small number of participants presents a normal weight status as well as an ideal waist circumference, values that are consistent with the literature (De Hert et al., 2011).”
BackgroundResult
Metadata
- Authors
- DE HERT, M., COHEN, D., BOBES, J., CETKOVICH‐BAKMAS, M., LEUCHT, S., NDETEI, D. M., NEWCOMER, J. W., UWAKWE, R., ASAI, I., MÖLLER, H., GAUTAM, S., DETRAUX, J., & CORRELL, C. U.
- Affiliations
- University of Groningen (NL)
- Universidad de Oviedo (ES)
- Technical University of Munich (DE)
- University of Nairobi (KE)
- Washington University in St. Louis (US)
- Nnamdi Azikiwe University (NG)
- SMS Medical College (IN)
- KU Leuven (BE)
- Albert Einstein College of Medicine (US)
- ORCID
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2011-06
- Volume
- 10
- Issue
- 2
- Pages
- 138-151
- ISSN
- 1723-8617 (ISSN-L)
- 2051-5545
- PMC
- PMC3104888
- OpenAlex
- W1828019950
- Cited by
- 870
- References
- 150
- Citations by year
- 2026: 39 · 2025: 50 · 2024: 50 · 2023: 57 · 2022: 68 · 2021: 54 · 2020: 72 · 2019: 76 · 2018: 68 · 2017: 56 · 2016: 79 · 2015: 57 · 2014: 37 · 2013: 57 · 2012: 39
- FWCI
- 31.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Pfizer
- Società Italiana di Psichiatria Biologica
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Keywords
- physical illness, severe mental illness, barriers to care, physical health screening, treatment guidelines, lifestyle risk factors, smoking, diet, physical activity, developing countries
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