Cited by 62Quantum Dots Synthesis And PropertiesHeavy Metal Exposure and ToxicityImmunotoxicology and immune responses

Acute toxicity and tissue distribution of CdSe/CdS‐MPA quantum dots after repeated intraperitoneal injection to mice

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Haque, Md. Mamunul, Im, Hye‐Yeon, Seo, Ji‐Eun, Hasan, Mahbub, Woo, Kyoungja, Kwon, Oh‐Seung·2013·Journal of Applied Toxicology

Abstract

Quantum dots (QDs) are novel tools with multiple biological and medical applications because of their superior photoemission and photostability characteristics. However, leaching of toxic metals from QDs is of great concern. Therefore, for the successful application of QDs in bioscience, it is essential to understand their biological fate and toxicity. We investigated toxicological effects and tissue distribution of mercaptopropionic acid‐conjugated cadmium selenide/cadmium sulfide (CdSe/CdS‐MPA) QDs after repeated intraperitoneal injection into BALB/c mice. The mice were injected every 3 days with various doses of QDs (0, 5, 10 and 25 mg kg−1). The subsequent effects of QDs on plasma levels of various biomarkers were evaluated at different time points (at 0, 1, 4, 7, 10, 13 and 15 days). Various tissue samples (spleen, liver, lung, kidneys, brain, heart and thymus) were collected for toxicity analysis, distribution testing, histopathological examination and inflammation assessment. No abnormal clinical signs or behaviors were recorded but the body weight of mice treated with 25 mg kg−1 QDs was significantly decreased from day 7 compared with control mice. QDs were observed in the liver, spleen, lung and kidneys, but not in brain or heart. Significantly higher levels of lactate dehydrogenase and nicotinamide adenine dinucleotide phosphate oxidase were found in the plasma, liver and spleen. Histopathological examination did not show any tissue toxicity but the levels of interleukin‐6, a pro‐inflammatory marker, were increased in the plasma, liver and spleen. All of these findings provide insight into the observed toxicological effect levels and tissue‐specific distribution of CdSe/CdS‐MPA QDs. Copyright © 2012 John Wiley & Sons, Ltd.

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Crossref · 10.1002/jat.2775

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Authors
Haque, M. M., Im, H., Seo, J., Hasan, M., Woo, K., & Kwon, O.
Affiliations
  • Korean Association Of Science and Technology Studies (KR)
  • Korea University (KR)
  • Toxicology Laboratory, Korea Institute of Science and Technology Seoul 136‐791 Korea
  • Korea Institute of Science and Technology (KR)
Corresponding author
Kwon, Oh‐Seung
Venue
Journal of Applied Toxicology
Publisher
Wiley
Published
2012-06-25
Volume
33
Issue
9
Pages
940-950
ISSN
  • 0260-437X (ISSN-L)
  • 1099-1263
OpenAlex
W2166026617
Cited by
62
References
44
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 2 · 2013: 2
FWCI
1.47
Type
journal article
Language
en
Open access
Locations
  • Journal of Applied Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
CdSe/CdS quantum dots, acute toxicity, tissue distribution, metal leaching, biomarkers, lactate dehydrogenase, NADPH oxidase, interleukin-6, inflammation, histopathology, weight loss, BALB/c mice
MeSH terms
Animals, Brain, Female, Heart, Injections, Intraperitoneal, Kidney, L-Lactate Dehydrogenase, Liver, Lung, Mice, Inbred BALB C, NADP, Spleen, Sulfides, Thymus Gland, Tissue Distribution, Interleukin-6, Selenium Compounds, Cadmium Compounds, Toxicity Tests, Acute, Quantum Dots, Mice

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