The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structure of a collagen‐GAG dermal skin substitute optimized for cultured human epidermal keratinocytes
Abstract
Collagen and glycosaminoglycan (GAG) dermal skin substitutes (membranes) were studied as substrates for cultured human epidermal keratinocytes. Structure of dermal substitutes was optimized for pore size to promote ingrowth of fibrovascular tissue from the wound bed and for culture of human keratinocytes of the membrane's surface. Pore size of the freeze‐dried material was regulated by control of the temperature of freezing between −50°C and −20°C and by concentration of starting materials between 0.17% and 1.62% wt/vol. A nonporous surface of collagen‐GAG was laminated to the membranes to provide a planar substrate for cultured epidermal kerationocytes. Thickness of dermal substitutes was regulated by control of the volume and concentration of starting materials. Biotin was conjugated to solubilized collagen for binding with avidin of specific quantities of biologically active molecules. The optimized membranes are suitable substrates for the culture of human epidermal keratinocytes, and together with the cells yield a composite material that is histologically similar to skin.
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Cites
Design of an artificial skin. Part III. Control of pore structure
Dagalakis, N., Flink, J., Stasikelis, P., Burke, J. F., & Yannas, I. V. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140417 · Cited by 358
Cited by
Biomaterials based on chitin and chitosan in wound dressing applications
Jayakumar, R., Prabaharan, M., Sudheesh Kumar, P. T., Nair, S. V., & Tamura, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.005 · Cited by 1,924
Collagen-Based Biomaterials for Tissue Engineering Applications
Parenteau-Bareil, R., Gauvin, R., & Berthod, F. (2010) · Materials · doi:10.3390/ma3031863 · Cited by 1,256
Collagen-based biomaterials for wound healing
Chattopadhyay, S., & Raines, R. T. (2014) · Biopolymers · doi:10.1002/bip.22486 · Cited by 1,041
Niehues, H., Bouwstra, J. A., El Ghalbzouri, A., Brandner, J. M., Zeeuwen, P. L. J. M., & van den Bogaard, E. H. (2018) · Experimental Dermatology · doi:10.1111/exd.13531 · Cited by 210
El Ghalbzouri, A., Commandeur, S., Rietveld, M. H., Mulder, A. A., & Willemze, R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.002 · Cited by 121
Metadata
- Authors
- Boyce, S. T., Christianson, D. J., & Hansbrough, J. F.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1988-10
- Volume
- 22
- Issue
- 10
- Pages
- 939-957
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2015551486
- Cited by
- 235
- References
- 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boyce, S. T., Christianson, D. J., & Hansbrough, J. F. (1988). Structure of a collagen‐GAG dermal skin substitute optimized for cultured human epidermal keratinocytes. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820221008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
