A mouse model to evaluate the interface between skin and a percutaneous device
Abstract
Percutaneous medical devices are integral in the management and treatment of disease. The space created between the skin and the device becomes a haven for bacterial invasion and biofilm formation and results in infection. We hypothesize that sealing this space via integration of the skin into the device will create a barrier against bacterial invasion. The purpose of this study was to develop an animal model in which the interaction between skin and biomaterials can be evaluated. Porous poly(2‐hydroxyethyl methacrylate) [poly(HEMA)] rods were implanted for 7 days in the dorsal skin of C57 BL/6 mice. The porous poly(HEMA) rods were surface‐modified with carbonyldiimidazole (CDI) or CDI plus laminin 5; unmodified rods served as control. Implant sites were sealed with 2‐octyl cyanoacrylate; corn pads and adhesive dressings were tested for stabilization of implants. All rods remained intact for the duration of the study. There was histological evidence of both epidermal and dermal integration into all poly(HEMA) rods regardless of treatment. This in vivo model permits examination of the implant/skin interface and will be useful for future studies designed to facilitate skin cell attachment where percutaneous devices penetrate the skin. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007
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Preliminary results suggested that a synthetic scaffold of spherical, interconnected, and tightly controlled pore sizes (30-40 μm in diameter) can vascularize rapidly in vivo with reduced fibrotic response.
“Preliminary results suggested that a synthetic scaffold of spherical, interconnected, and tightly controlled pore sizes (30–40 μm in diameter) can vascularize rapidly in vivo with reduced fibrotic response (10, 11).”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [11]
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Guo, Z.-X., Huang, Z.-F., Wang, Z., Zhao, X.-L., Cao, C.-W., Wu, J., Zheng, Y., & Xu, M. (2026) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000012668
- Authors
- Isenhath, S. N., Fukano, Y., Usui, M. L., Underwood, R. A., Irvin, C. A., Marshall, A. J., Hauch, K. D., Ratner, B. D., Fleckman, P., & Olerud, J. E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Olerud, J. E.
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2007-06-13
- Volume
- 83A
- Issue
- 4
- Pages
- 915-922
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2021503231
- Cited by
- 59
- References
- 42
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 9 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 7 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 59221, R01DK059221)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- poly(2-hydroxyethyl methacrylate), porous biomaterials, laminin-5, 2-octyl cyanoacrylate, adhesive dressings, implant stabilization, bacterial infection prevention, biofilm formation, mouse model
- MeSH terms
- Animals, Biocompatible Materials, Polyhydroxyethyl Methacrylate, Skin, Skin Absorption, Models, Animal, Mice
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