Comparison of ciprofloxacin hydrochloride‐loaded protein, lipid, and chitosan nanoparticles for drug delivery
Abstract
The aim of the present study was to develop single dose delivery systems based on nanotechnology for prolonged antibiotic release in a controlled manner. Five different drug–carrier ratios of ciprofloxacin hydrochloride‐loaded nanoparticles of albumin, gelatin, chitosan (CS), and lipid [solid lipid nanoparticles (SLNs)] were prepared and characterized. Average particle size was found to be in the range of 73 ± 2 to 98 ± 44 nm for SLNs, 140 ± 7 to 175 ± 24 nm for albumin nanoparticles, 143 ± 18 to 184 ± 27 nm for gelatin nanoparticles, and 247 ± 48 to 322 ± 52 nm for CS nanoparticles. A drug‐to‐carrier ratio of 0.5:1 was preferred for CS nanoparticles having zeta potential of >20 mV and drug encapsulation of 35.01% ± 2.66%. Similarly, 0.6:1 ratio was preferred for albumin nanoparticles with zeta potential >16 mV and drug encapsulation 48.20% ± 3.01%. Zeta potentials of gelatin nanoparticles loaded with ciprofloxacin suggested that they were unstable and prone to flocculation. SLN with 0.25:1 drug carrier ratio showed 38.71% ± 2.38% drug entrapment and −28 ± 1 mV surface charge. All the nanoparticles showed sustained drug release avoiding “burst effect” of the free drugs for up to 120 h for albumin nanoparticles, 96 h for CS and gelatin nanoparticles, and 80 h for SLNs. The drug release profiles followed Higuchi model. Results suggest that CS nanoparticles and SLNs can act as promising carriers for sustained ciprofloxacin release in infective conditions. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
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Jain et al. showed that solid lipid nanoparticles were able to promote prolonged drug release for ciprofloxacin encapsulation.
“Jain et al. used different nanocarriers for ciprofloxacin encapsulation and showed that SLNs were able to promote a prolonged drug release.215”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [215]
Solid lipid nanoparticles were also capable of loading other anti-TB drugs, such as rifabutin, INH, RIF, and PZA.
“Apart from ciprofloxacin, SLNs were also capable of loading other anti-TB drugs, such as rifabutin, INH, RIF, and PZA.215”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [215]
Jain and Banerjee demonstrated sustained release of ciprofloxacin up to 80 h.
“Jain and Banerjee also demonstrated the sustained release of ciprofloxacin (up to 80 h).215”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [215]
Solid lipid nanoparticles have been extensively used in formulations for the delivery of anti-TB drugs.
“SLNs have been extensively used in formulations for the delivery of anti-TB drugs.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [215]
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- Authors
- Jain, D., & Banerjee, R.
- Affiliations
- Indian Institute of Technology Bombay (IN)
- Corresponding author
- Banerjee, R.
- Venue
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Publisher
- Wiley
- Published
- 2007-12-20
- Volume
- 86B
- Issue
- 1
- Pages
- 105-112
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- OpenAlex
- W2074420216
- Cited by
- 158
- References
- 34
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 18 · 2016: 15 · 2015: 7 · 2014: 5 · 2013: 11 · 2012: 4
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- DSpace (IIT Bombay) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- ciprofloxacin hydrochloride, chitosan nanoparticles, solid lipid nanoparticles, albumin nanoparticles, gelatin nanoparticles, sustained drug release, encapsulation efficiency, zeta potential, Higuchi model, burst release, nanoparticle stability
- MeSH terms
- Albumins, Animals, Cattle, Ciprofloxacin, Drug Carriers, Gelatin, Lipids, Particle Size, Polymers, Scattering, Radiation, Serum Albumin, Drug Delivery Systems, Nanotechnology, Chitosan, Nanoparticles
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