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The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial
Open accessAbstract
Intentional weight loss is an important treatment option for overweight persons with type 2 diabetes mellitus (DM), but the effects on long-term fracture risk are not known. The purpose of this Look AHEAD analysis was to evaluate whether long-term intentional weight loss would increase fracture risk in overweight or obese persons with DM. Look AHEAD is a multicenter, randomized clinical trial. Recruitment began in August 2001 and follow-up continued for a median of 11.3 years at 16 academic centers. A total of 5145 persons aged 45 to 76 years with DM were randomized to either an intensive lifestyle intervention (ILI) with reduced calorie consumption and increased physical activity designed to achieve and maintain ≥7% weight loss or to diabetes support and education intervention (DSE). Incident fractures were ascertained every 6 months by self-report and confirmed with central adjudication of medical records. The baseline mean age of participants was 59 years, 60% were women, 63% were white, and the mean BMI was 36 kg/m2. Weight loss over the intervention period (median 9.6 years) was 6.0% in ILI and 3.5% in DSE. A total of 731 participants had a confirmed incident fracture (358 in DSE versus 373 in ILI). There were no statistically significant differences in incident total or hip fracture rates between the ILI and DSE groups. However, compared to the DSE group, the ILI group had a statistically significant 39% increased risk of a frailty fracture (HR 1.39; 95% CI, 1.02 to 1.89). An intensive lifestyle intervention resulting in long-term weight loss in overweight/obese adults with DM was not associated with an overall increased risk of incident fracture but may be associated with an increased risk of frailty fracture. When intentional weight loss is planned, consideration of bone preservation and fracture prevention is warranted. © 2017 American Society for Bone and Mineral Research.
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“However, 2017 data from the Look AHEAD trial showed that long-term intentional weight loss was associated with a 39% increased risk of fragility fractures325.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [325]
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“However, compared to the DSE group, the ILI group had a statistically significant 39% increased risk of a frailty fracture (HR = 1.39, 95% CI 1.02, 1.89). [32]”
From New drugs for the treatment of obesity: do we need approaches to preserve muscle mass? (2025) · cites this paper as [32]
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“Reduced LBM may be of additional clinical importance given its association with decreased bone mineral density and increased risk of fractures, as well as its relation to metabolic function (e.g., insulin sensitivity) and aerobic capacity [72, 73].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [72]
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Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 1×
“changes in body composition including a loss of lean body mass with a concomitant increase in fat mass.((28,29)) In the Look AHEAD DXA subgroup, lean body mass decreased more in the ILI than DSE between baseline and year 1 and remained lower through year 8.”
BackgroundSelf-citationCardiovascular effects of intensive lifestyle intervention in type 2 diabetes
The Look AHEAD Research Group (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212914 · Cited by 2,908 · cited 1×
“However, despite these changes in lean body mass, the ILI group increased their physical activity resulting in improved fitness.(31) Further in the Look AHEAD trial, the weight loss and improved fitness have been shown to slow the decline in mobility in the ILI group compared to the DSE group.”
Dawson‐Hughes, B., Harris, S. S., Krall, E. A., & Dallal, G. E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709043371003 · Cited by 2,276
Kanis, J. А., Borgström, F., Laet, C. E. D. H. D., Johansson, H., Johnell, O., Jönsson, B., Odén, A., Zethraeus, N., Pfleger, B., & Khaltaev, N. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1780-5 · Cited by 1,257
Prevention of falls and consequent injuries in elderly people
Kannus, P., Sievänen, H. T., Palvanen, M., Järvinen, T. L. N., & Parkkari, J. P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67604-0 · Cited by 1,128
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096
Smoking and fracture risk: a meta-analysis
Kanis, J. A., Johnell, O., Oden, A., Johansson, H., De Laet, C., Eisman, J. A., Fujiwara, S., Kroger, H., McCloskey, E. V., Mellstrom, D., et al. (2005) · Osteoporosis International · doi:10.1007/s00198-004-1640-3 · Cited by 999
An estimate of the worldwide prevalence, mortality and disability associated with hip fracture
Johnell, O., & Kanis, J. A. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1627-0 · Cited by 962
The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It
The Look AHEAD Research Group (2006) · Obesity · doi:10.1038/oby.2006.84 · Cited by 873
Mortality after osteoporotic fractures
Johnell, O., Kanis, J. А., Odén, A., Sernbo, I., Redlund-Johnell, I., Petterson, C., Laet, C. E. D. H. D., & Jönsson, B. (2003) · Osteoporosis International · doi:10.1007/s00198-003-1490-4 · Cited by 852
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Strasser, B., Wolters, M., Weyh, C., Krüger, K., & Ticinesi, A. (2021) · Nutrients · doi:10.3390/nu13062045 · Cited by 192
Wadden, T. A., Chao, A. M., Moore, M., Tronieri, J. S., Gilden, A., Amaro, A., Leonard, S., & Jakicic, J. M. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00534-z · Cited by 129
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Armamento‐Villareal, R., Aguirre, L. E., Waters, D. L., Napoli, N., Qualls, C., & Villareal, D. T. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3905 · Cited by 114
Avenell, A., Robertson, C., Skea, Z., Jacobsen, E., Boyers, D., Cooper, D., Aceves‐Martins, M., Retat, L., Fraser, C. M., Aveyard, P. N., et al. (2018) · Health Technology Assessment · doi:10.3310/hta22680 · Cited by 103
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Paccou, J., Tsourdi, E. A., Meier, C., Palermo, A., Pepe, J., Body, J.-J., & Zillikens, M. C. (2021) · Bone · doi:10.1016/j.bone.2021.116236 · Cited by 76
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Choksi, P. U., Rothberg, A. E., Kraftson, A. T., Miller, N., Zurales, K. R., Burant, C., Poznak, C. H. V., & Peterson, M. D. (2018) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-018-0063-6 · Cited by 11
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Gregori, G., Mediwala, S. N., Liebschner, M. A. K., Kim, D., Bryant, M. S., Klonis, N., Armamento‐Villareal, R., Qualls, C., & Villareal, D. T. (2025) · The Lancet Healthy Longevity · doi:10.1016/j.lanhl.2025.100761 · Cited by 7
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Ahn, J., Park, H. S., Cho, S., Baek, S., Rhee, Y., & Hong, N. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae010 · Cited by 3
Xin, Z., Xu, H., Zhang, X., Samelson, E. J., Kiel, D. P., & Liu, C. (2024) · Osteoporosis International · doi:10.1007/s00198-024-07068-7 · Cited by 3
Chung, J., Park, S., Park, S. J., Kim, H. J., Kim, J., Lee, H., Jeong, S., Park, Y. J., Hyung, K. K., Shin, H.-Y., et al. (2025) · The American Journal of Medicine · doi:10.1016/j.amjmed.2025.12.014 · Cited by 2
Sclerostin deficiency sensitizes white adipocytes to thermogenic signals that induce beiging in mice
Choquette, G. M., Kim, S. P., Wilkinson, K. J., Avelar, B., Pathy, S. M., Li, Z., Wu, J. M. F., Aja, S. M., Thorek, D. L. J., Wolfgang, M. J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69227-0 · Cited by 2
Ambrogini, E. (2026) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjag069 · Cited by 2
Beavers, K. M., Serra, M. C., Weaver, A. A., & Houston, D. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00035-6 · Cited by 3
Elam, R. E., Johnson, K., Xu, H., Isales, C. M., Dong, Y., & Carbone, L. D. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae623 · Cited by 2
Self-citationVery Low-Energy Diets—Opportunity for Greater Weight Loss, but Risk of Bone Loss
Steur, M. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.13752 · Cited by 1
Karam, L. B., & Paccou, J. (2025) · Obesity · doi:10.1002/oby.24341 · Cited by 1
Reid, K. F., & Bhasin, S. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1640030 · Cited by 4
Monitoring and reporting of adverse effects in weight loss trials in children
Alcoat, C., & Køster‐Rasmussen, R. (2025) · Danish Medical Journal · doi:10.61409/a05240327 · Cited by 1
Conte, C., Bouillon, R., & Napoli, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00040-3 · Cited by 1
Kim, C. S., Choi, H. S., Bae, E. H., Kwon, S., Kim, B., Han, K., & Kim, S. W. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.912152
Araújo, M. M., Mendes, M. M., Costa, L. M., Lima, R. M., Lanham-New, S. A., de Carvalho, K. M. B., & Botelho, P. B. (2022) · Nutrition · doi:10.1016/j.nut.2022.111937
Lee, S. E., Yoo, J., Kim, B., Kim, K., Han, K., & Choi, H. S. (2023) · Archives of Osteoporosis · doi:10.1007/s11657-023-01240-y
Zhao, P., Sheng, Z., Xu, L., Li, P., Xiao, W., Yuan, C., Xu, Z., Yang, M., Qian, Y., Zhong, J., et al. (2023) · eLife · doi:10.7554/elife.89281.1
Ageing and Mid-Life Adult Considerations
Deaton, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-53705-9_23
Prévention et traitement de la fragilité osseuse chez les sujets diabétiques de type 2
Paccou, J. (2025) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2025.03.002
Kushner, R. F., Ryan, D. H., Harder-Lauridsen, N. M., Jeppesen, O. K., Kallenbach, K., Lincoff, A. M., & Lingvay, I. (2025) · Obesity · doi:10.1002/oby.24345
He, J. H., Bennett, W. L., Ma, J., Oyeka, C. P., Kodali, L. S., Srialluri, N., Gisinger, T., Woodward, M., Michos, E. D., Johnson, K., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf359
Self-citationBone Health and Obesity Treatments: It's Time to Give Bone Its Due
Dubin, R. L. (2025) · Obesity · doi:10.1002/oby.70074
Fracture Risk by Post-Cessation Weight Change in Men with Newly Diagnosed Type 2 DiabetesPreprint
Chung, J., Park, S., Park, S. J., Kim, H. J., Jaewon, K., Lee, H., Jeong, S., Park, Y. J., Kim, K. H., Shin, H.-Y., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5390860
Arsenyadis, F., Henson, J. J., McCarthy, M., Papamargaritis, D., King, J. A., Redman, E., Whelehan, G., Wilkinson, T., Sargeant, J. A., Rowlands, A. V., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-110459
He, J. H., Oyeka, C. P., Ma, J. Z., Srialluri, N., Gisinger, T., Woodward, M., Michos, E. D., Johnson, K., Moseley, K. F., Bennett, W. L., et al. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag089
Self-citationSigurdardottir, G. A., Køster‐Rasmussen, R., Meyer, L. B., Sandholdt, C. T., Christiansen, A.-K. L., Specht, I. O., Lindschou, J., Engstrøm, J., Heitmann, B. L., Bojsen-Møller, K. N., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2026-116962
Impact of glucagon-like peptide-1 receptor agonists on bone metabolism
Vadini, V., Duan, D., & Moseley, K. F. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag323 · Cited by 1
Metadata
- Authors
- Johnson, K. C., Bray, G. A., Cheskin, L. J., Clark, J. M., Egan, C. M., Foreyt, J. P., Garcia, K. R., Glasser, S., Greenway, F. L., Gregg, E. W., Hazuda, H. P., Hergenroeder, A., Hill, J. O., Horton, E. S., Jakicic, J. M., Jeffery, R. W., Kahn, S. E., Knowler, W. C., Lewis, C. E., Miller, M., Montez, M. G., Nathan, D. M., Patricio, J. L., Peters, A. L., Pi-Sunyer, X., Pownall, H. J., Reboussin, D., Redmon, J. B., Steinberg, H., Wadden, T. A., Wagenknecht, L. E., Wing, R. R., Womack, C. R., Yanovski, S. Z., Zhang, P., Schwartz, A. V., & for the Look AHEAD Study Group
- Affiliations
- University of Tennessee Health Science Center (US)
- Pennington Biomedical Research Center (US)
- Johns Hopkins University (US)
- Weight Control and Diabetes Research CenterProvidenceRIUSA
- Baylor College of Medicine (US)
- Wake Forest University Health Sciences (US)
- University of Alabama (US)
- Centers for Disease Control and Prevention (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- University of Colorado Anschutz (US)
- Joslin Diabetes Center (US)
- University of Minnesota (US)
- University of Washington (US)
- Southwestern American Indian CenterPhoenixAZUSA
- Harvard University (US)
- St. Luke's-Roosevelt Hospital Center (US)
- University of Southern California (US)
- Columbia University Medical CenterNew YorkNYUSA
- Houston Methodist (US)
- University of Pennsylvania (US)
- Brown University (US)
- National Institutes of Health (US)
- Centers for Disease Control and PreventionAtlantaGAUSA
- University of California, San Francisco (US)
- Corresponding author
- Johnson, Karen C
- ORCID
- Johnson, Karen C
- Bray, George A
- Cheskin, Lawrence J
- Clark, Jeanne M
- Glasser, Stephen
- Greenway, Frank L
- Gregg, Edward W
- Hazuda, Helen P
- Hergenroeder, Andrea
- Hill, James O
- Horton, Edward S
- Jakicic, John M
- Kahn, Steven E
- Knowler, William C
- Lewis, Cora E
- Peters, Anne L
- Pownall, Henry J
- Reboussin, David
- Redmon, J Bruce
- Wadden, Thomas A
- Wagenknecht, Lynne E
- Wing, Rena R
- Schwartz, Ann V
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-05
- Volume
- 32
- Issue
- 11
- Pages
- 2278-2287
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC5685890
- OpenAlex
- W2727111851
- Cited by
- 104
- References
- 43
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 12 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 9
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health (DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, DK56992, DK 046204)
- National Heart, Lung, and Blood Institute
- National Center on Minority Health and Health Disparities
- Office of Research on Women's Health
- Centers for Disease Control and Prevention
- National Institute of Diabetes and Digestive and Kidney Diseases
- Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719)
- Massachusetts General Hospital (M01RR01066)
- Harvard Catalyst (RR025758-04)
- University of Colorado (M01RR00051)
- Clinical Nutrition Research Unit (P30 DK48520)
- University of Tennessee (M01RR0021140)
- University of Pittsburgh (M01RR000056)
- Clinical Translational Research Center (CTRC) funded by the Clinical & Translational Science Award (UL1 RR 024153)
- U.S. Department of Veterans Affairs (M01RR01346)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- intentional weight loss, fracture risk, type 2 diabetes, intensive lifestyle intervention, diabetes support and education, hip fracture, obesity, overweight, Look AHEAD trial, bone preservation, fracture prevention
- MeSH terms
- Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Factors, Weight Loss, Incidence, Proportional Hazards Models, Fractures, Bone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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