The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Bone resorption activity of particulate-stimulated macrophages
Abstract
Particulate wear debris from bone cement or prosthetic components can stimulate macrophages to cause bone resorption in a dose-dependent manner. This bone resorption activity of particulate-stimulated macrophages is associated with increased levels of both prostaglandin E2 (PGE2) and interleukin-1 (IL-1). In this study we compared the effect of particulate size, concentration, and composition on the secretion of IL-1 and PGE2 by peritoneal macrophages and on the bone-resorbing activity of conditioned medium (CM) harvested from particulate-challenged macrophages. Particulates (titanium, Ti; polymethylmethacrylate, PMMA; and polystyrene, PS) only with phagocytosable size stimulated peritoneal macrophages to secrete IL-1 and PGE2 in a dose- and time-dependent manner. Ti particles (1–3 μm) exhibited significantly enhanced bone-resorbing activity measured as 45Ca release. The maximum bone-resorbing response was observed at a concentration of 0.1% Ti (approximately 10–15 Ti particulates per cell), which also corresponded with the highest IL-1 levels measured in particulate-challenged CM. This was measured using either conditioned media from Ti-stimulated macrophages or in cocultures of calvarial bone and macrophages in the presence of Ti. Exogenous PGE2 and recombinant human IL-1 could significantly increase the 45Ca release; indomethacin (IM) significantly reduced both the spontaneous calcium efflux and active 45Ca release from in vivo labeled calvarial bones. However, IM and/or anti-Il-1 antibodies could suppress only partly the macrophage-mediated bone resorption, indicating that, in a macrophage-bone coculture system, factors other than PGE2 and IL-1 also may regulate particulate-induced bone resorption, probably involving multiple cell types.
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Citations
Cites
An interleukin 1 like factor stimulates bone resorption in vitro
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Reactions of the articular capsule to wear products of artificial joint prostheses
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Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes
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Macrophages stimulate bone resorption when they phagocytose particles
Murray, D., & Rushton, N. (1990) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.72b6.2246303 · Cited by 402
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Self-citationEffects of Interleukin-1 on Bone Turnover in Normal Mice*
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Cited by
Biological reactions to wear debris in total joint replacement
Ingham, E., & Fisher, J. (2000) · Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine · doi:10.1243/0954411001535219 · Cited by 708
Moro, T., Takatori, Y., Ishihara, K., Konno, T., Takigawa, Y., Matsushita, T., Chung, U.-I., Nakamura, K., & Kawaguchi, H. (2004) · Nature Materials · doi:10.1038/nmat1233 · Cited by 572
Doorn, P. F., Campbell, P. A., Worrall, J., Benya, P. D., McKellop, H. A., & Amstutz, H. C. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199810)42:1<103::aid-jbm13>3.0.co;2-m · Cited by 431
Composition and morphology of wear debris in failed uncemented total hip replacement
Shanbhag, A., Jacobs, J., Glant, T., Gilbert, J., Black, J., & Galante, J. (1994) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.76b1.8300684 · Cited by 387
Self-citationBi, Y., Seabold, J. M., Kaar, S. G., Ragab, A. A., Goldberg, V. M., Anderson, J. M., & Greenfield, E. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.11.2082 · Cited by 227
Metadata
- Authors
- Glant, T. T., Jacobs, J. J., Molnár, G., Shanbhag, A. S., Valyon, M., & Galante, J. O.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-09-01
- Volume
- 8
- Issue
- 9
- Pages
- 1071-1079
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2074094806
- Cited by
- 309
- References
- 31
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- closed
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