Composition and morphology of wear debris in failed uncemented total hip replacement
Abstract
Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip replacements were examined. Particles in the membranes were characterised by electron microscopy, microchemical spectroscopy and particle size analysis. Most were polyethylene and had a mean size of 0.53 micron +/- 0.3. They were similar to the particles seen in the base resin used in the manufacture of the acetabular implants. Relatively few titanium particles were seen. Fragments of bone, stainless steel and silicate were found in small amounts. Most of the polyethylene particles were too small to be seen by light microscopy. Electron microscopy and spectroscopic techniques are required to provide an accurate description of this debris.
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Wear byproducts from total joint replacements include particulate polymeric, ceramic, and metallic debris and metallic ions, which cause pro-inflammatory responses that can persist for the life of the implant.
“The byproducts of wear include particulate polymeric, ceramic and metallic debris (mostly in the nano, submicron, and micron size range) and in the case of metal-on-metal implants, metallic ions [143]. These byproducts are well known to cause pro-inflammatory responses which can persist for the life of the implant [144,145].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [143]
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MethodInfluentialMurine model of prosthesis failure for the long‐term study of aseptic loosening
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NUMBER OF POLYETHYLENE PARTICLES AND OSTEOLYSIS IN TOTAL JOINT REPLACEMENTS
Kobayashi, A., Freeman, M., Bonfield, W., Kadoya, Y., Yamac, T., Al-Saffar, N., Scott, G., & Revell, P. (1997) · doi:10.1302/0301-620x.79b5.0790844 · Cited by 69
Garrigues, G. E., Cho, D. R., Rubash, H. E., Goldring, S. R., Herndon, J. H., & Shanbhag, A. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.034 · Cited by 58 · see citing works
Self-citationVermes, C., Glant, T., Hallab, N., Fritz, E. A., Roebuck, K., & Jacobs, J. (2001) · Journal of Arthroplasty · doi:10.1054/arth.2001.28719 · Cited by 68 · see citing works
Self-citationHailey, J. L., Ingham, E., Stone, M. H., Wroblewski, B., & Fisher, J. (1996) · Proceedings of the Institution of mechanical engineers. Part H, journal of engineering in medicine · doi:10.1243/pime_proc_1996_210_385_02 · Cited by 65
Positive cytokine production in failed metal-on-metal total hip replacements
Campbell, P., Wang, M. Y., Amstutz, H., & Goodman, S. (2002) · Acta Orthopaedica Scandinavica · doi:10.1080/000164702321022767 · Cited by 62
“Most of the metal wear particles analyzed by Doorn et al. are below this range, but most polyethylene particles are within it (Shanbhag et al. 1994).”
BackgroundDeng, Z.-T., Wang, Z.-H., Jin, J., Wang, Y., Bao, N.-R., Gao, Q., & Zhao, J.-N. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.051 · Cited by 61 · see citing works
“studies have suggested that biomaterial wear particles such as UHMWPE (ultra-high molecular weight 407 polyethylene), titanium, Cobalt Chromium, PMMA (polymethylmethacrylate) particles were generated 408 during the daily functions of the prosthetic joint, which are believed playing a critical role in the 409 pathogene…”
Background
- Authors
- Shanbhag, A., Jacobs, J., Glant, T., Gilbert, J., Black, J., & Galante, J.
- Affiliations
- Rush University (US)
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 1994-01
- Volume
- 76-B
- Issue
- 1
- Pages
- 60-67
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W1914858881
- Cited by
- 387
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 11 · 2012: 9
- FWCI
- 26.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Bone and Joint Surgery - British Volume (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- wear debris, cementless total hip arthroplasty, revision hip arthroplasty, polyethylene wear particles, titanium alloys, interfacial membrane, particle size, implant failure, bone fragments, stainless steel particles, silicate particles
- MeSH terms
- Aged, Cementation, Female, Hip Joint, Hip Prosthesis, Humans, Male, Microscopy, Electron, Scanning, Middle Aged, Particle Size, Polyethylenes, Prosthesis Failure, Reoperation, Titanium, Spectroscopy, Fourier Transform Infrared
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