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Long-term fracture prediction by bone mineral assessed at different skeletal sites

Dr. Melton, L. Joseph, Atkinson, Elizabeth J., O'Fallon, W. Michael, Wahner, Heinz W., Riggs, B. Lawrence·1993·Journal of Bone and Mineral Research

Abstract

Bone mineral density (BMD) was measured at the lumbar spine and cervical and intertrochanteric regions of the proximal femur by dual-photon absorptiometry and bone mineral content was assessed at the distal and midradius by single-photon absorptiometry in an age-stratified random sample of 304 Rochester, Minnesota women aged 30–94 years. Over follow-up extending to 10 years (median 8.3 years), 93 women experienced 163 new fractures. After adjusting for age, these bone mineral measurements predicted the likelihood of any incident fracture due to moderate trauma, with relative hazards varying from 1.4 to 1.6 per SD decrease in baseline bone mineral. A 1 SD decrease in lumbar spine BMD increased the risk of a new vertebral fracture comparably to a 17 year increase in age; a 1 SD decrease in femoral BMD was comparable to a 13–14 year increase in age on the risk of a hip fracture. We conclude that bone mineral measurements made at a variety of skeletal sites can predict the occurrence for at least 8–10 years of moderate trauma fractures of the sort that might be related to osteoporosis.

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Metadata

Authors
Dr. Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Wahner, H. W., & Riggs, B. L.
Venue
Journal of Bone and Mineral Research
Published
1993-10-01
Volume
8
Issue
10
Pages
1227-1233
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
OpenAlex
W2010793737
Cited by
862
References
3
FWCI
39.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Long-term fracture prediction by bone mineral assessed at different skeletal sites. https://app.cochat.ai/papers/10.1002/jbmr.5650081010
The paper
Dr. Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Wahner, H. W., & Riggs, B. L. (1993). Long-term fracture prediction by bone mineral assessed at different skeletal sites. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.5650081010

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