The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Progression of Aortic Calcification Is Associated With Metacarpal Bone Loss During Menopause: A Population-Based Longitudinal Study
Open accessAbstract
Abstract —Atherosclerosis and osteoporosis are major causes of morbidity and mortality in postmenopausal women and have been suggested to be associated. No study has examined whether progression of atherosclerotic calcification is associated with bone loss. In the present study, we examined progression of aortic calcification, diagnosed by radiographic detection of calcified deposits in the abdominal aorta, in relation to metacarpal bone loss, as assessed by metacarpal radiogrammetry, during menopause. Initially premenopausal women (n=236), aged 45 to 57 years at baseline, were followed for 9 years. We additionally assessed the cross-sectional association between the extent of aortic calcification and metacarpal bone mass and density in 720 postmenopausal women. Twenty-five percent of women going through menopause showed progression of aortic calcification. The average loss of metacarpal bone mass among women with progression of aortic calcification was 3.2 mm 2 , and their loss of metacarpal bone density was 7.2 mm 2 %, whereas in women without progression of aortic calcification, these losses were 2.0 mm 2 and 5.6 mm 2 %, respectively, adjusted for age and years of follow-up ( P <0.05). Additional adjustment for age at menopause, body mass index, blood pressure, smoking, diabetes mellitus, and use of hormone replacement therapy, thiazide, and loop diuretics did not influence these results. In postmenopausal women, a graded inverse cross-sectional association between the extent of aortic calcification and metacarpal bone mass and density was found. In conclusion, our results indicate that progression of atherosclerotic calcification is associated with increased bone loss in women during menopause.
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Cites
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Cited by
Arterial Calcifications and Bone Histomorphometry in End-Stage Renal Disease
London, G. M., Marty, C., Marchais, S. J., Guerin, A. P., Metivier, F., & de Vernejoul, M.-C. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000129337.50739.48 · Cited by 594
Aortic calcification and the risk of osteoporosis and fractures.
Schulz, E., Arfai, K., Liu, X., Sayre, J., & Gilsanz, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030964 · Cited by 429
Osteoporosis, inflammation and ageing
Ginaldi, L., Di Benedetto, M. C., & De Martinis, M. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-14 · Cited by 412
Kumeda, Y., Inaba, M., Goto, H., Nagata, M., Henmi, Y., Furumitsu, Y., Ishimura, E., Inui, K., Yutani, Y., Miki, T., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10269 · Cited by 313
Role of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders
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Metadata
- Authors
- Hak, A. E., Pols, H. A. P., van Hemert, A. M., Hofman, A., & Witteman, J. C. M.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2000-08
- Volume
- 20
- Issue
- 8
- Pages
- 1926-1931
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2038340127
- Cited by
- 375
- References
- 50
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Progression of Aortic Calcification Is Associated With Metacarpal Bone Loss During Menopause: A Population-Based Longitudinal Study. https://app.cochat.ai/papers/10.1161/01.atv.20.8.1926
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- Hak, A. E., Pols, H. A. P., van Hemert, A. M., Hofman, A., & Witteman, J. C. M. (2000). Progression of Aortic Calcification Is Associated With Metacarpal Bone Loss During Menopause: A Population-Based Longitudinal Study. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.20.8.1926
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
