The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
β‐Catenin signaling in biological control and cancer
Abstract
A coordinated integration of cell–cell adhesion and the control of gene expression is essential for the development of multicellular, differentiated organisms. β‐Catenin fulfils important regulatory functions in both cell–cell adhesion by linking cadherin adhesion receptors to the cytoskeleton, and also as a key element in the Wnt signaling pathway where it acts as cotranscriptional activator of target genes in the cell nucleus. Wnt signaling is involved in numerous aspects of embryonic development and in the control of tissue self‐renewal in a variety of adult tissues. Hyperactivation of Wnt signaling, mostly by affecting β‐catenin functions, is a hallmark of colon cancer and of many other human cancers. In this prospect, we discuss studies pointing to the molecular mechanisms that govern the integration between cell–cell adhesion and gene expression, as reflected in the switches between these two functions of β‐catenin in colon cancer cells. J. Cell. Biochem. 102: 820–828, 2007. © 2007 Wiley‐Liss, Inc.
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Cites
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
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Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
The snail superfamily of zinc-finger transcription factors
Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719
Cited by
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299
Adherens junctions: from molecules to morphogenesis
Harris, T. J. C., & Tepass, U. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2927 · Cited by 990
Lazar, A. J. F., Tuvin, D., Hajibashi, S., Habeeb, S., Bolshakov, S., Mayordomo-Aranda, E., Warneke, C. L., Lopez-Terrada, D., Pollock, R. E., & Lev, D. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080475 · Cited by 455
Salvi, S., Fontana, V., Boccardo, S., Merlo, D. F., Margallo, E., Laurent, S., Morabito, A., Rijavec, E., Dal Bello, M. G., Mora, M., et al. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1211-y · Cited by 133
Yang, C., Iyer, R. R., Yu, A. C. H., Yong, R. L., Park, D. M., Weil, R. J., Ikejiri, B., Brady, R. O., Lonser, R. R., & Zhuang, Z. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118754109 · Cited by 80
Metadata
- Authors
- Gavert, N., & Ben‐Ze'ev, A.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2007-09-13
- Volume
- 102
- Issue
- 4
- Pages
- 820-828
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2105080125
- Cited by
- 164
- References
- 4
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- closed
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