The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
NF‐κB and epithelial to mesenchymal transition of cancer
Open accessAbstract
During progression of an in situ to an invasive cancer, epithelial cells lose expression of proteins that promote cell–cell contact, and acquire mesenchymal markers, which promote cell migration and invasion. These events bear extensive similarities to the process of epithelial to mesenchymal transition (EMT), which has been recognized for several decades as critical feature of embryogenesis. The NF‐κB family of transcription factors plays pivotal roles in both promoting and maintaining an invasive phenotype. After briefly describing the NF‐κB family and its role in cancer, in this review we will first describe studies elucidating the functions of NF‐κB in transcription of master regulator genes that repress an epithelial phenotype. In the second half, we discuss the roles of NF‐κB in control of mesenchymal genes critical for promoting and maintaining an invasive phenotype. Overall, NF‐κB is identified as a key target in prevention and in the treatment of invasive carcinomas. J. Cell. Biochem. 104: 733–744, 2008. © 2008 Wiley‐Liss, Inc.
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Cites
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 2×
“…of dimeric transcription factors distinguished by the presence of an N-terminal 300 amino acid region, termed the Rel homology domain (RHD), which contains sequences mediating dimerization, DNA binding, nuclear localization, and interaction with inhibitory IkB proteins [Ghosh and Karin, 2002].”
The snail superfamily of zinc-finger transcription factors
Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719
Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology · doi:10.1038/ncb1173 · Cited by 1,581
Ohkubo, T., & Ozawa, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01004 · Cited by 322
Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2
Wang, X., Belguise, K., Kersual, N., Kirsch, K. H., Mineva, N. D., Galtier, F., Chalbos, D., & Sonenshein, G. E. (2007) · Nature Cell Biology · doi:10.1038/ncb1559 · Cited by 209
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Inflammation: A driving force speeds cancer metastasis
Wu, Y., & Zhou, B. P. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9699 · Cited by 327
Kong, D., Li, Y., Wang, Z., Banerjee, S., Ahmad, A., Kim, H.-R. C., & Sarkar, F. H. (2009) · Stem Cells · doi:10.1002/stem.101 · Cited by 311
Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis
Frisch, S. M., Schaller, M., & Cieply, B. (2013) · Journal of Cell Science · doi:10.1242/jcs.120907 · Cited by 295
Maier, H. J., Schmidt-Straßburger, U., Huber, M. A., Wiedemann, E. M., Beug, H., & Wirth, T. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.003 · Cited by 215
Metadata
- Authors
- Min, C., Eddy, S. F., Sherr, D. H., & Sonenshein, G. E.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2008-02-05
- Volume
- 104
- Issue
- 3
- Pages
- 733-744
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W1992101294
- Cited by
- 376
- References
- 5
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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