The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis
Open accessAbstract
Summary: The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in various context-dependent ways, including increased metastatic potential, expansion of cancer stem cell subpopulations, chemo-resistance and disease recurrence. One of the hallmarks of EMT is resistance of tumor cells to anoikis. This resistance contributes to metastasis and is a defining property not only of EMT but also of cancer stem cells. Here, we review the mechanistic coupling between EMT and resistance to anoikis. The discussion focuses on several key aspects. First, we provide an update on new pathways that lead from the loss of E-cadherin to anoikis resistance. We then discuss the relevance of transcription factors that are crucial in wound healing in the context of oncogenic EMT. Next, we explore the consequences of the breakdown of cell-polarity complexes upon anoikis sensitivity, through the Hippo, Wnt and transforming growth factor β (TGF-β) pathways, emphasizing points of crossregulation. Finally, we summarize the direct regulation of cell survival genes through EMT-inducing transcription factors, and the roles of the tyrosine kinases focal adhesion kinase (FAK) and TrkB neurotrophin receptor in EMT-related regulation of anoikis. Emerging from these studies are unifying principles that will lead to improvements in cancer therapy by reprogramming sensitivity of anoikis.
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Cites
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Cited by
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“Also, the cell528 matrix interactions established in 3D could prevent anoikis-apoptosis due to detachment from 529 the matrix[64] of those tumoural cells that have not acquired yet all the mutations to survive 530 in a ECM-free milieu, thus facilitating the maintenance of heterogeneous, non-selected 531 populations wi…”
FAK in cancer: mechanistic findings and clinical applications
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Gonzalez-Avila, G., Sommer, B., Mendoza-Posada, D. A., Ramos, C., Garcia-Hernandez, A. A., & Falfan-Valencia, R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.02.010 · Cited by 373
Metadata
- Authors
- Frisch, S. M., Schaller, M., & Cieply, B.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2013-01-01
- Volume
- 126
- Issue
- 1
- Pages
- 21-29
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2076036054
- Cited by
- 295
- References
- 104
- FWCI
- 14.54
- Type
- journal article
- Language
- en
- Open access
- green
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