The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
The wnt/β‐catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer
Open accessAbstract
Breast cancer continues to be a serious health problem particularly in developed countries. Of particular concern is triple negative breast cancer (TNBC) which does not respond well to standard hormone therapy and is associated with poor overall patient prognosis. Recent studies indicate that Wnt/β‐catenin signaling is particularly activated in TNBC, such that the Wnt receptor frizzled‐7 (FZD7) and the Wnt co‐receptor LRP6 were found to be up regulated in TNBC. In addition, it has been demonstrated that transcriptional knockdown of LRP6 or FZD7 in TNBC cells suppressed tumor growth in vivo. Furthermore, salinomycin, a selective breast cancer stem cell killer, was recently demonstrated to be an inhibitor of Wnt/β‐catenin signaling by inducing LRP6 degradation. Therefore, the Wnt/β‐catenin signaling pathway and particularly the Wnt receptors on the cell surface may serve as novel therapeutic targets for the treatment of TNBC. J. Cell. Biochem. 113: 13–18, 2012. © 2011 Wiley Periodicals, Inc.
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Prospective identification of tumorigenic breast cancer cells
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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt signalling in stem cells and cancer
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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
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The many ways of Wnt in cancer
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Cited by
Lu, W., Lin, C., Roberts, M. J., Waud, W. R., Piazza, G. A., & Li, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029290 · Cited by 230
Self-citationAmyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer
Lim, S., Yoo, B. K., Kim, H.-S., Gilmore, H. L., Lee, Y., Lee, H.-P., Kim, S.-J., Letterio, J., & Lee, H.-G. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-928 · Cited by 100
Effect of Niclosamide on Basal-like Breast Cancers
Londoño-Joshi, A. I., Arend, R. C., Aristizabal, L., Lu, W., Samant, R. S., Metge, B. J., Hidalgo, B., Grizzle, W. E., Conner, M., Forero-Torres, A., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0555 · Cited by 97
Self-citationNasser, F., Moussa, N., Helmy, M. W., & Haroun, M. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01988-x · Cited by 29
Upreti, M., Jyoti, A., Johnson, S. E., Swindell, E. P., Napier, D., Sethi, P., Chan, R., Feddock, J. M., Weiss, H. L., O’Halloran, T. V., et al. (2106) · Oncotarget · doi:10.18632/oncotarget.9490 · Cited by 21
Metadata
- Authors
- King, T. D., Suto, M. J., & Li, Y.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2011-12-09
- Volume
- 113
- Issue
- 1
- Pages
- 13-18
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2011366619
- Cited by
- 296
- References
- 48
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- green
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