Acute physical exercise increases leptin-induced hypothalamic extracellular signal-regulated kinase1/2 phosphorylation and thermogenesis of obese mice
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Abstract The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypothalamus by leptin. The hypothalamic extracellular signal‐regulated kinase‐1/2 (ERK1/2) is a key mediator of the thermoregulatory effect of leptin and mediates the sympathetic signal to the brown adipose tissue (BAT). In this context, physical exercise is one of the main interventions for the treatment of obesity. Thus, this study aimed to verify the effects of acute physical exercise on leptin‐induced hypothalamic ERK1/2 phosphorylation and thermogenesis in obese mice. Here we showed that acute physical exercise reduced the fasting glucose of obese mice and increased leptin‐induced hypothalamic p‐ERK1/2 and uncoupling protein 1 (UCP1) content in BAT ( P < 0.05). These molecular changes are accompanied by an increased oxygen uptake (VO 2) and heat production in obese exercised mice ( P < 0.05). The increased energy expenditure in the obese exercised animals occurred independently of changes in spontaneous activity. Thus, this is the first study demonstrating that acute physical exercise can increase leptin‐induced hypothalamic ERK1/2 phosphorylation and energy expenditure of obese mice.
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Acute physical exercise leads to an increase in BAT UCP-1 protein expression in HFD-treated Swiss mice and ICR mice.
“As an example, acute physical exercise leads to an increase in BAT UCP-1 protein expression in HFD-treated (High Fat Diet) Swiss mice [194] and ICR (Institute of Cancer Research) mice [195].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [194]
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Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
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- Authors
- Gaspar, R. C., Muñoz, V. R., Kuga, G. K., Nakandakari, S. C. B. R., Minuzzi, L. G., Botezelli, J. D., da Silva, A. S. R., Cintra, D. E., de Moura, L. P., Ropelle, E. R., & Pauli, J. R.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Laboratory of Molecular Biology of Exercise (LaBMEx) University of Campinas (UNICAMP) Limeira São Paulo Brazil
- Universidade Estadual Paulista (Unesp) (BR)
- School of Physical Education and Sports of Ribeirão Preto Post‐graduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP Ribeirão Preto São Paulo Brazil
- Corresponding author
- Pauli, José Rodrigo
- ORCID
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2018-09-11
- Volume
- 120
- Issue
- 1
- Pages
- 697-704
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2890910766
- Cited by
- 21
- References
- 27
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (306535/2017‐3)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2016/18488‐8OCRC)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- acute exercise, leptin, ERK1/2 phosphorylation, hypothalamus, thermogenesis, obesity, brown adipose tissue, UCP1, energy expenditure, oxygen consumption, fasting blood glucose
- MeSH terms
- Uncoupling Protein 1, Animals, Body Weight, Adipose Tissue, Brown, Energy Metabolism, Hypothalamus, Injections, Intraperitoneal, Mice, Obese, Obesity, Oxygen Consumption, Phosphorylation, Physical Conditioning, Animal, Leptin, MAP Kinase Signaling System, Thermogenesis, Mice, Diet, High-Fat
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