Reference distributions for serum iron and transferrin saturation: A comparison of a large cohort to the world's literature
Open accessAbstract
The appropriate clinical use of serum iron and transferrin saturation (TSAT) requires satisfactory reference intervals from birth to old age, and for males and females. This study identified 54 publications from 1974 to 2001 that met the criteria used in three prior meta‐analyses, and these were analyzed statistically. A summary of our review is presented along with our reference population data on these measurements. This analysis places previous publications in perspective and suggests possible reasons for the observed differences. Previous studies of the individual analytes, serum iron, transferrin, and TSAT values agree with the reference ranges presented in this study, although the entire experience over time and between sexes has not been available before. Our 95% reference ranges are somewhat broader than those of the smaller studies, but they agree well with those of the larger ones. J. Clin. Lab. Anal. 16:246–252, 2002. © 2002 Wiley‐Liss, Inc.
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Iron stores tend to increase with age, partly due to dietary reasons.
“Iron stores tend to increase with age [1151-1155], partly due to dietary reasons [1156]”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1152]
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Self-citation
- Authors
- F. Ritchie, R., E. Palomaki, G., M. Neveux, L., Navolotskaia, O., B. Ledue, T., & Y.Craig, W.
- Affiliations
- Foundation for Blood Research (US)
- Venue
- Journal of Clinical Laboratory Analysis
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 16
- Issue
- 5
- Pages
- 246-252
- ISSN
- 0887-8013 (ISSN-L)
- 1098-2825
- PMC
- PMC6807718
- OpenAlex
- W2086216298
- Cited by
- 17
- References
- 72
- Citations by year
- 2026: 3 · 2023: 1 · 2022: 1 · 2019: 3 · 2017: 2 · 2012: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Laboratory Analysis (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- serum iron, transferrin saturation, reference values, reference distribution, iron metabolism, transferrin, sex differences, age differences
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Iron, Male, Middle Aged, Reference Values, Transferrin, Cohort Studies
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