The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The placebo is powerful: Estimating placebo effects in medicine and psychotherapy from randomized clinical trials
Abstract
The logic of the randomized double-blind placebo control group design is presented, and problems with using the design in psychotherapy are discussed. Placebo effects are estimated by examining clinical trials in medicine and psychotherapy. In medicine, a recent meta-analysis of clinical trials with treatment, placebo, and no treatment arms was conducted (Hróbjartsson & Gøtzsche, 2001), and it was concluded that placebos have small or no effects. A re-analysis of those studies, presented here, shows that when disorders are amenable to placebos and the design is adequate to detect the effects, the placebo effect is robust and approaches the treatment effect. For psychological disorders, particularly depression, it has been shown that pill placebos are nearly as effective as active medications whereas psychotherapies are more effective than psychological placebos. However, it is shown that when properly designed, psychological placebos are as effective as accepted psychotherapies.
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Elkin, I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110013002 · Cited by 2,300 · cited 1×
“The first result is that psychological treatments of depression are generally equivalent to psychopharmacological treatments of depression (Elkin et al., 1989; Hollon et al., 1992).”
ResultCredibility of analogue therapy rationales
Borkovec, T. D., & Nau, S. D. (1972) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(72)90045-6 · Cited by 1,553 · cited 2×
“Over the years, many have commented on the nature of placebo treatments as a control for psychotherapeutic treatments in clinical trials (Basham, 1986; Borkovec & Nau, 1972; Brody, 1980; Horvath, 1988; Lambert & Ogles, 2004; O’Leary & Borkovec, 1978; Sheppard, 1993; Wampold, 1997, 2001a, 2001b).”
BackgroundA component analysis of cognitive-behavioral treatment for depression.
Jacobson, N. S., Dobson, K. S., Truax, P. A., Addis, M. E., Koerner, K., Gollan, J. K., Gortner, E., & Prince, S. E. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.2.295 · Cited by 1,413
Frank, J. (1993) · doi:10.56021/9780801840678 · Cited by 1,094
Wampold, B. E., Mondin, G. W., Moody, M., Stich, F., Benson, K., & Ahn, H.-N. (1997) · Psychological Bulletin · doi:10.1037/0033-2909.122.3.203 · Cited by 1,091
Self-citationTesting the integrity of a psychotherapy protocol: Assessment of adherence and competence
Waltz, J., Addis, M. E., Koerner, K., & Jacobson, N. S. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.4.620 · Cited by 873
Borkovec, T. D., & Costello, E. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.4.611 · Cited by 756
The researcher's own therapy allegiances: A "wild card" in comparisons of treatment efficacy.
Luborsky, L., Diguer, L., Seligman, D. A., Rosenthal, R., Krause, E. D., Johnson, S., Halperin, G., Bishop, M., Berman, J. S., & Schweizer, E. (1999) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.6.1.95 · Cited by 572 · cited 1×
“Given that allegiance has been shown to be related to outcomes (see Luborsky et al., 1999; Wampold, 2001b) and that most placebo treatments are administered by advocates of the active treatment or are trained by advocates of the active treatment, as well as the difficulty in faithfully and…”
BackgroundCognitive Therapy and Pharmacotherapy for Depression: Singly and in Combination
Hollon, S. D. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820100018004 · Cited by 481 · cited 1×
“The first result is that psychological treatments of depression are generally equivalent to psychopharmacological treatments of depression (Elkin et al., 1989; Hollon et al., 1992).”
Result
Cited by
The psychological effects of meditation: a meta-analysis
Sedlmeier, P., Eberth, J., Schwarz, M., Zimmermann, D., Haarig, F., Jaeger, S., & Kunze, S. (2012) · Psychological Bulletin · doi:10.1037/a0028168 · Cited by 910
Carpenter, J. K., Andrews, L. A., Witcraft, S. M., Powers, M. B., Smits, J. A. J., & Hofmann, S. G. (2018) · Depression and Anxiety · doi:10.1002/da.22728 · Cited by 846
Placebo interventions for all clinical conditions
Hróbjartsson, A., & Gøtzsche, P. C. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003974.pub3 · Cited by 777
Watts, R., Day, C., Krzanowski, J., Nutt, D., & Carhart-Harris, R. (2017) · Journal of Humanistic Psychology · doi:10.1177/0022167817709585 · Cited by 589
Goldberg, S. B., Riordan, K. M., Sun, S., & Davidson, R. J. (2022) · Perspectives on Psychological Science · doi:10.1177/1745691620968771 · Cited by 520
“The challenge of applying the double-blind placebo-controlled design is not unique to MBIs but exists for all behavioral interventions (Wampold et al., 2005).”
The self-regulating brain and neurofeedback: experimental science and clinical promise
Thibault, R. T., Lifshitz, M., & Raz, A. (2016) · Cortex · doi:10.1016/j.cortex.2015.10.024 · Cited by 272
Cognitive behavioural therapies for fibromyalgia
Bernardy, K., Klose, P., Busch, A. J., Choy, E. H., & Häuser, W. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009796.pub2 · Cited by 272
Driessen, E., Cuijpers, P., Hollon, S. D., & Dekker, J. J. M. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0020570 · Cited by 208
From many to (n)one: Meditation and the plasticity of the predictive mind
Laukkonen, R. E., & Slagter, H. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.021 · Cited by 187
Conley, C. S., Shapiro, J. B., Kirsch, A. C., & Durlak, J. A. (2017) · Journal of Counseling Psychology · doi:10.1037/cou0000190 · Cited by 159
Kirkham, J. G., Choi, N., & Seitz, D. P. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4358 · Cited by 136
Sigurvinsdóttir, A. L., Jensínudóttir, K. B., Baldvinsdóttir, K. D., Smárason, O., & Skarphedinsson, G. (2020) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2019.1686653 · Cited by 130
Barkowski, S., Schwartze, D., Strauss, B., Burlingame, G. M., Barth, J., & Rosendahl, J. (2016) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.02.005 · Cited by 134
Flik, C. E., Laan, W., Zuithoff, N. P. A., van Rood, Y. R., Smout, A. J. P. M., Weusten, B. L. A. M., Whorwell, P. J., & de Wit, N. J. (2019) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(18)30310-8 · Cited by 126
Placebo effects in psychotherapy: a framework
Enck, P., & Zipfel, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00456 · Cited by 115
Thibault, R. T., Lifshitz, M., Birbaumer, N., & Raz, A. (2015) · Psychotherapy and Psychosomatics · doi:10.1159/000371714 · Cited by 112
The use of waitlists as control conditions in anxiety disorders research
Patterson, B., Boyle, M. H., Kivlenieks, M., & Van Ameringen, M. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.015 · Cited by 94
van Aubel, E., Bakker, J. M., Batink, T., Michielse, S., Goossens, L., Lange, I., Schruers, K., Lieverse, R., Marcelis, M., van Amelsvoort, T., et al. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103592 · Cited by 57
Pammi, M., Shah, P. S., Yang, L. K., Hagan, J., Aghaeepour, N., & Neu, J. (2025) · The Lancet Digital Health · doi:10.1016/j.landig.2025.01.007 · Cited by 60
Zoogman, S., Goldberg, S. B., Vousoura, E., Diamond, M. C., & Miller, L. (2019) · Spirituality in Clinical Practice · doi:10.1037/scp0000202 · Cited by 41
Herbert, J. D., & Gaudiano, B. A. (2005) · Journal of Clinical Psychology · doi:10.1002/jclp.20133 · Cited by 44
A talking control for use in evaluating the effectiveness of cognitive-behavioral therapy
Serfaty, M., Csipke, E., Haworth, D., Murad, S., & King, M. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.05.005 · Cited by 30
Metadata
- Authors
- Wampold, B. E., Minami, T., Tierney, S. C., Baskin, T. W., & Bhati, K. S.
- Venue
- Journal of Clinical Psychology
- Publisher
- Wiley
- Published
- 2005
- Volume
- 61
- Issue
- 7
- Pages
- 835-854
- ISSN
- 0021-9762 (ISSN-L)
- 1097-4679
- OpenAlex
- W1966770824
- Cited by
- 298
- References
- 9
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
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