The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
BMP‐2 and BMP‐9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL‐1
Abstract
Bone morphogenetic proteins play important roles in connective tissue morphogenesis. In this study, we used human multipotential mesenchymal cells as a target to analyze the effect of bone morphogenetic proteins on chondrogenesis. We also analyzed the effect of proinflammatory cytokine interleukin‐1 on chondrogenic‐differentiated cells and the interaction of IL‐1β with bone morphogenetic proteins. Cells placed in a 3‐dimensional matrix of alginate beads and cultured in a serum‐free media with bone morphogenetic protein‐2 and ‐9 induced expression of type II collagen (Col2A1) mRNA and increased expression of aggrecan and cartilage oligomeric matrix protein suggesting chondrogenic differentiation of the cells. The transcription factor Sox‐9 that regulates both Col2A1 and aggrecan gene expression showed increased expression with BMP treatment. Chondrogenic differentiated cells treated with interleukin‐1 decreased Sox‐9, Col2A1 and aggrecan gene expression. Removal of interleukin‐1 and further addition of bone morphogenetic proteins resulted in returned expression of chondrogenic markers. Chondrogenic differentiated cells cultured in the presence of different concentrations of bone morphogenetic proteins and interleukin‐1 showed that bone morphogenetic proteins were able to partially block the suppressive effect of interleukin‐1. This study shows that bone morphogenetic proteins play an important role in chondrogenesis and may prove to be potential therapeutics in cartilage repair. © 2001 Wiley‐Liss, Inc.
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Cites
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The Chondrogenic Potential of Human Bone-Marrow-Derived Mesenchymal Progenitor Cells*
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Cited by
Chung, C., & Burdick, J. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.027 · Cited by 760
Developments in the scientific understanding of osteoarthritis
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Crystal Structure of BMP-9 and Functional Interactions with Pro-region and Receptors
Brown, M. A., Zhao, Q., Baker, K. A., Naik, C., Chen, C., Pukac, L., Singh, M., Tsareva, T., Parice, Y., Mahoney, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503328200 · Cited by 299
Metadata
- Authors
- Majumdar, M. K., Wang, E., & Morris, E. A.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2001-10-10
- Volume
- 189
- Issue
- 3
- Pages
- 275-284
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2120032969
- Cited by
- 286
- References
- 44
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Majumdar, M. K., Wang, E., & Morris, E. A. (2001). BMP‐2 and BMP‐9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL‐1. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.10025
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