CoChat
Sign Up
Cited by 123Connexins and lens biologyIon Transport and Channel RegulationCellular Mechanics and Interactions

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Contact inhibition of division: Involvement of the electrical transmembrane potential

Cone, Clarence D., Tongier, Max·1973·Journal of Cellular Physiology
DOI 10.1002/jcp.1040820307
Open this paper in CoChat — free account

Abstract

Measurements of simultaneous mitotic activity, electrical transmembrane potential (E m ), and cell density levels in both 3T3 and Chinese hamster ovary (CHO) cell cultures reveal that a 5‐ to 6‐fold increase in the E m level is associated with development of mitotic arrest at saturation densities. This rise occurs both in confluent monolayers and in interior areas of isolated colonies, and is independent of the rate at which confluence is attained. The E m rise is accompanied by a substantial decrease in intracellular Na. Electron microscopy of saturated CHO monolayer sections shows from 46 to 63% of the cell surfaces to be in close apposition (<300 Å spacing). These results for contact inhibited cultures support the hypothesis that mitotic activity may be functionally coupled with the E m level and associated ionic concentration levels. It is suggested that contact inhibition of mitosis may result from a reduction in synthesis of mitogenically essential RNA following a decrease in intracellular Na produced by contact‐induced alteration of surface ion‐transport activity.

Overview

Integrity signals

Registry

Crossref · 10.1002/jcp.1040820307

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Hyperpolarized Vm immediately precedes mitotic arrest.

    “By contrast, hyperpolarized Vm immediately precedes mitotic arrest (Cone and Tongier, 1973).”

    From Membrane potential and cancer progression (2013) · cites this paper as Cone and Tongier, 1973

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 52

  1. 10.1002/jcp.1040690105 · DOI
  2. Balitsky K. P., 1964, Resting potential of malignant tumor cells, Acta Unio Inter. Con. Cancrum, 20, 1393
  3. Bollum F. J., 1959, Nucleic acid metabolism in regenerating rat liver VI, soluble enzymes which convert thymidine to thymidine phosphates and deoxyribonucleic acid, Canc. Res., 19, 561
  4. 10.1083/jcb.35.1.279 · DOI
  5. 10.1016/0014-4827(71)90426-5 · DOI
  6. 10.1073/pnas.68.1.229 · DOI
  7. 10.1111/j.2164-0947.1969.tb02926.x · DOI · Paper page
  8. 10.1016/0022-5193(71)90042-7 · DOI · Paper page
  9. 10.1159/000224567 · DOI
  10. 10.1016/0014-4827(69)90023-8 · DOI
  11. 10.1073/pnas.64.3.1049 · DOI
  12. 10.1159/000386007 · DOI
  13. 10.1073/pnas.66.1.204 · DOI
  14. 10.1126/science.122.3168.501 · DOI · Paper page
  15. 10.1084/jem.131.4.863 · DOI
  16. Eagle K., 1957, Myo inositol as an essential growth factor for normal and malignant human cells in tissue culture, J. Biol. Chem., 226, 191, 10.1016/S0021-9258(18)64820-3 · DOI
  17. 10.1126/science.155.3762.581 · DOI
  18. 10.1002/jcp.1030510208 · DOI
  19. 10.1016/S0014-4827(63)80014-2 · DOI
  20. 10.1085/jgp.41.3.565 · DOI
  21. 10.1002/jcp.1030600302 · DOI
  22. Hodgkin A. L., 1964, The conduction of the nervous impulse
  23. 10.1073/pnas.60.1.300 · DOI
  24. Hülser D. F., 1971, Stimulation of embryonic rat cells in culture by a protein fraction isolated from fetal calf serum. I. Electrophysiological measurements at the cell surface membranes, Zeitschrift fuer Naturforschung (in German), Part B, 26, 1045, 10.1515/znb-1971-1018 · DOI
  25. 10.1038/218775a0 · DOI
  26. 10.1016/0014-4827(69)90168-2 · DOI
  27. 10.1152/jn.1966.29.4.768 · DOI
  28. Lieberman I., 1963, Levels of enzyme activity and DNA synthesis in mammalian cells cultared from the animal, J. Biol. Chem., 238, 3955, 10.1016/S0021-9258(18)51812-3 · DOI
  29. 10.1021/bi00834a039 · DOI
  30. 10.1016/S0065-2423(08)60388-1 · DOI
  31. 10.1016/0014-4827(65)90306-X · DOI
  32. 10.1073/pnas.69.1.243 · DOI · Paper page
  33. 10.1002/jcp.1040790208 · DOI
  34. 10.1002/jcp.1040710102 · DOI
  35. 10.1073/pnas.68.10.2497 · DOI
  36. 10.1085/jgp.60.4.430 · DOI
  37. 10.1002/jcp.1040710108 · DOI
  38. 10.1016/0042-6822(58)90114-4 · DOI · Paper page
  39. 10.1084/jem.108.2.259 · DOI
  40. 10.1083/jcb.35.1.53 · DOI
  41. 10.1083/jcb.17.2.299 · DOI
  42. 10.1073/pnas.51.1.66 · DOI
  43. 10.1002/jcp.1030660310 · DOI
  44. Todaro G. J., 1967, Growth Regulating Substances for Animal Cells in Culture, 87
  45. 10.1002/jcp.1030620305 · DOI
  46. Tsukada K., 1964, Synthesis of RNA by liver nuclear and nucleolar preparations after partial hepatectomy, J. Biol. Chem., 239, 2952, 10.1016/S0021-9258(18)93837-8 · DOI
  47. 10.1016/0014-4827(69)90296-1 · DOI
  48. Vasiliev J. M., 1966, Behaviour of fibroblasts in cell culture after removal of a part of monolayer, Dok. Akad. Nauk SSSR (in Russian), 171, 111
  49. 10.1073/pnas.68.5.977 · DOI
  50. 10.1002/jcp.1040750307 · DOI
  51. 10.1073/pnas.49.2.171 · DOI
  52. Wiebel J. F., 1968, Stimulation of DNA synthesis in confluent monolayers of human fibroblasts, Federation Proc., 27, 411

Cited by

Sorted by citations

Metadata

Authors
Cone, C. D., & Tongier, M.
Affiliations
Langley Research Center (US)
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
1973-12
Volume
82
Issue
3
Pages
373-386
ISSN
  • 0021-9541 (ISSN-L)
  • 1097-4652
DOI
10.1002/jcp.1040820307
OpenAlex
W2156775082
Cited by
123
References
1
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11388 d)
Locations
  • Journal of Cellular Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
membrane potential, electric potential, mitotic arrest, cell density, sodium ions, 3T3 fibroblasts, CHO cells, cell confluence, ion transport, RNA synthesis
MeSH terms
Animals, Cell Count, Cell Line, Cells, Cultured, Contact Inhibition, Electron Probe Microanalysis, Electron Transport, Female, Cricetinae, Membrane Potentials, Microscopy, Electron, Microscopy, Phase-Contrast, Mitosis, Motion Pictures, Ovary, Potassium, RNA, Sodium, Time Factors, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review