Cited by 242Mitochondrial Function and PathologyAdipose Tissue and MetabolismAutophagy in Disease and Therapy

Distinct genomic copy number in mitochondria of different mammalian organs.

Veltri, Karen L., Espiritu, Myrna, Singh, Gurmit·1990·Journal of Cellular Physiology

Abstract

This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ-specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.

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Crossref · 10.1002/jcp.1041430122

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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  • Electron microscopy demonstrates that mitochondrial area is 44% lower in liver than in heart with smaller size, fewer cristae, and lower matrix density.

    “Electron microscopy demonstrates that mitochondrial area is 44% lower in liver than in heart (210) with smaller size, fewer cristae, and lower matrix density.”

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Authors
Veltri, K. L., Espiritu, M., & Singh, G.
Affiliations
McMaster University (CA)
Corresponding author
Singh, Gurmit
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
1990-04
Volume
143
Issue
1
Pages
160-164
ISSN
  • 0021-9541 (ISSN-L)
  • 1097-4652
OpenAlex
W2030868673
Cited by
242
References
19
Citations by year
2026: 1 · 2025: 6 · 2024: 6 · 2023: 17 · 2022: 9 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 6
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cellular Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
McMaster University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial density, mitochondrial DNA copy number, mouse organs, liver, kidney, heart, brain, stereology
MeSH terms
Animals, Brain, DNA, Mitochondrial, Kidney, Mice, Inbred C57BL, Microscopy, Electron, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mice

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