Distinct genomic copy number in mitochondria of different mammalian organs.
Abstract
This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ-specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Electron microscopy demonstrates that mitochondrial area is 44% lower in liver than in heart with smaller size, fewer cristae, and lower matrix density.
“Electron microscopy demonstrates that mitochondrial area is 44% lower in liver than in heart (210) with smaller size, fewer cristae, and lower matrix density.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [210]
Cites
A low-viscosity epoxy resin embedding medium for electron microscopy.
Spurr, A. (1969) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(69)90033-1 · Cited by 13,268 · see citing works
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works
Sequence and gene organization of mouse mitochondrial DNA.
Bibb, M., Etten, R. V., Wright, C. T., Walberg, M. W., & Clayton, D. A. (1981) · Cell · doi:10.1016/0092-8674(81)90300-7 · Cited by 1,619 · see citing works
Replication of animal mitochondrial DNA
Clayton, D. A. (1982) · Cell · doi:10.1016/0092-8674(82)90049-6 · Cited by 1,236 · see citing works
Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells
Robin, E. D., & Wong, R. J. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041360316 · Cited by 656 · see citing works
The Number of Mitochondrial Deoxyribonucleic Acid Genomes in Mouse L and Human HeLa Cells
Bogenhagen, D. F., & Clayton, D. A. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42063-2 · Cited by 526 · see citing works
TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Clayton, D. A. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.003041 · Cited by 446 · see citing works
Williams, R. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67252-7 · Cited by 273 · see citing works
Mitochondrial DNA: Advances, Problems, and Goals
Nass, M. M. K. (1969) · Science · doi:10.1126/science.165.3888.25 · Cited by 212 · see citing works
Mitochondrial DNA I. Preparation and properties of mitochondrial DNA from chick liver
Borst, P., Ruttenberg, G. J. C. M., & Kroon, A. M. (1967) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(67)90697-1 · Cited by 122 · see citing works
Novikoff, A. B., & Holtzman, E. (1984) · Cited by 117 · see citing works
Deoxyribonucleic acid in isolated rat-liver mitochondria
Nass, S., Nass, M. M. K., & Hennix, U. (1965) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(65)90189-9 · Cited by 107 · see citing works
MITOCHONDRIAL DNA FROM PROTOZOA
Suyama, Y., & Preer, J. R. (1965) · Genetics · doi:10.1093/genetics/52.5.1051 · Cited by 97 · see citing works
Allard, C., MATHIEU, R., de Lamirande, G., & Cantero, A. (1952) · PubMed · Cited by 94 · see citing works
The isolation and some properties of rat liver mitochondrial deoxyribonucleic acid.
Schneider, W., & Kuff, E. L. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.6.1650 · Cited by 76 · see citing works
Biosynthesis of DNA by Isolated Mitochondria: Incorporation of Thymidine Triphosphate-2-C 14
Parsons, P. G., & Simpson, M. V. (1967) · Science · doi:10.1126/science.155.3758.91 · Cited by 75 · see citing works
Suyama, Y., & Bonner, W. D. (1966) · PLANT PHYSIOLOGY · doi:10.1104/pp.41.3.383 · Cited by 72 · see citing works
A possible cellular mechanism of cisplatin-induced nephrotoxicity
Singh, G. (1989) · Toxicology · doi:10.1016/0300-483x(89)90105-4 · Cited by 68 · see citing works
Self-citationThe differentiation of animal mitochondria during development
POLLAK, J. K., & Sutton, R. (1980) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(80)80073-9 · Cited by 49 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES
Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059 · see citing works
Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00926-7 · Cited by 889 · see citing works
Counting with DNA in metabarcoding studies: How should we convert sequence reads to dietary data?
Deagle, B. E., Thomas, A. C., McInnes, J. C., Clarke, L. J., Vesterinen, E. J., Clare, E. L., Kartzinel, T. R., & Eveson, J. P. (2018) · Molecular Ecology · doi:10.1111/mec.14734 · Cited by 834 · see citing works
Mitochondrial dysfunction and molecular pathways of disease
Pieczenik, S. R., & Neustadt, J. O. (2007) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2006.09.008 · Cited by 638 · see citing works
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546 · see citing works
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works
Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?
Malik, A. N., & Czajka, A. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.10.011 · Cited by 499 · see citing works
Regulation of Mitochondrial ATP Production: Ca2+ Signaling and Quality Control
Boyman, L., Karbowski, M., & Lederer, W. J. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.007 · Cited by 309 · see citing works
Rodríguez-Navarro, J. A., Rodríguez, L., Casarejos, M. J., Solano, R. M., Gómez, A., Perucho, J., Cuervo, A. M., García de Yébenes, J., & Mena, M. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.014 · Cited by 298 · see citing works
Diagnoses of neuronal ceroid‐lipofuscinosis by immunochemical methods
Hosain, S. A., Kaufmann, W. E., Negrin, G., Watkins, P. A., Siakotos, A. N., Palmer, D. N., & Naidu, S. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320570226 · Cited by 256 · see citing works
Length heteroplasmy in the first hypervariable segment of the human mtDNA control region.
Bendall, K. E., & Sykes, B. C. (1995) · Europe PMC (PubMed Central) · Cited by 233 · see citing works
Mitochondrial DNA polymerase-γ and human disease
Hudson, G., & Chinnery, P. F. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl233 · Cited by 221 · see citing works
Tissue-specific differences in mitochondrial activity and biogenesis
Fernández‐Vizarra, E., Enrı́quez, J. A., Martos, A. P., Montoya, J., & Fernández‐Silva, P. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.09.011 · Cited by 195 · see citing works
Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application
Szilágyi, M., Pös, O., Márton, É., Buglyó, G., Soltész, B., Keserű, J. S., Penyige, A., Szemes, T., & Nagy, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186827 · Cited by 193 · see citing works
Metabarcoding a diverse arthropod mock community
Braukmann, T., Ivanova, N. V., Prosser, S. W. J., Elbrecht, V., Steinke, D., Ratnasingham, S., de Waard, J. R., Sones, J. E., Zakharov, E., & Hebert, P. D. N. (2019) · Molecular Ecology Resources · doi:10.1111/1755-0998.13008 · Cited by 189 · see citing works
Mitochondrial function in development and disease
Rossmann, M. P., Dubois, S. M., Agarwal, S., & Zon, L. I. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048912 · Cited by 191 · see citing works
Mitochondrial copy number and risk of breast cancer: A pilot study
Shen, J., Platek, M., Mahasneh, A., Ambrosone, C. B., & Zhao, H. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.09.004 · Cited by 162 · see citing works
Mitochondrial Roles and Cytoprotection in Chronic Liver Injury
Esposti, D. D., Hamelin, J., Bosselut, N., Saffroy, R., Sebagh, M., Pommier, A., Martel, C., & Lemoine, A. (2012) · Biochemistry Research International · doi:10.1155/2012/387626 · Cited by 159 · see citing works
Medication‐induced mitochondrial damage and disease
Neustadt, J. O., & Pieczenik, S. R. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700075 · Cited by 158 · see citing works
High‐throughput monitoring of wild bee diversity and abundance via mitogenomics
Tang, M., Hardman, C. J., Ji, Y., Meng, G., Liu, S., Tan, M., Yang, S., Moss, E. D., Wang, J., Yang, C., et al. (2015) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12416 · Cited by 144 · see citing works
Scaling properties of cell and organelle size
Chan, Y.-H. M., & Marshall, W. F. (2010) · Organogenesis · doi:10.4161/org.6.2.11464 · Cited by 127 · see citing works
Mitochondrial Variability as a Source of Extrinsic Cellular Noise
Johnston, I. G., Gaál, B., das Neves, R. P., Enver, T., Iborra, F. J., & Jones, N. S. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002416 · Cited by 116 · see citing works
Antiviral chemotherapy for the treatment of hepatitis b virus infections
Torresi, J., & LOCARNINI, S. A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70008-4 · Cited by 124 · see citing works
O'Hara, R., Tedone, E., Ludlow, A., Huang, E., Arosio, B., Mari, D., & Shay, J. W. (2019) · Genome Research · doi:10.1101/gr.250480.119 · Cited by 121 · see citing works
Mitochondrial density determines the cellular sensitivity to cisplatin-induced cell death
Qian, W., Nishikawa, M., Haque, A. M., Hirose, M., Mashimo, M., Sato, E. F., & Inoue, M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00265.2005 · Cited by 119 · see citing works
Human Mitochondrial Diseases: Answering Questions and Questioning Answers
Howell, N. (1998) · International review of cytology · doi:10.1016/s0074-7696(08)61051-7 · Cited by 118 · see citing works
The Evolution of Per-cell Organelle Number
Cole, L. W. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00085 · Cited by 116 · see citing works
Biju-Duval, C., Ennafaa, H., Dennebouy, N., Monnerot, M., Mignotte, F., Soriguer, R. C., Gaaïed, A. E., Hili, A. E., & Mounolou, J. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02100200 · Cited by 113 · see citing works
Fischel‐Ghodsian, N., Bykhovskaya, Y., Taylor, K. D., Kahen, T., Cantor, R. M., Ehrenman, K., Smith, R. J., & Keithley, E. M. (1997) · Hearing Research · doi:10.1016/s0378-5955(97)00077-4 · Cited by 105 · see citing works
Evidence for aerobic ATP synthesis in isolated myelin vesicles
Ravera, S., Panfoli, I., Calzia, D., Aluigi, M. G., Bianchini, P., Diaspro, A., Mancardi, G., & Morelli, A. M. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.01.009 · Cited by 101 · see citing works
Nuclear targeting signal recognition: a key control point in nuclear transport?
Jans, D. A., Xiao, C.-Y., & Lam, M. H. C. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200006)22:6 · Cited by 519 · see citing works
D’Souza, A. D., Parikh, N. S., Kaech, S. M., & Shadel, G. S. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.08.001 · Cited by 99 · see citing works
Melatonin for the treatment of sepsis: the scientific rationale
Biancatelli, R. M. L. C., Berrill, M., Mohammed, Y. H., & Marik, P. E. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.12.85 · Cited by 95 · see citing works
Hu, L., Yao, X., & Shen, Y. (2016) · Scientific Reports · doi:10.1038/srep35859 · Cited by 94 · see citing works
Oxidized mitochondrial DNA: a protective signal gone awry
Xian, H., & Karin, M. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.01.006 · Cited by 94 · see citing works
Forensic applications of mitochondrial DNA
Butler, J. M., & Levin, B. C. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01173-1 · Cited by 92 · see citing works
Mitochondrial off targets of drug therapy
Wallace, K. B. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.04.001 · Cited by 90 · see citing works
The role of mitochondria in rheumatic diseases
Becker, Y. L. C., Duvvuri, B., Fortin, P. R., Lood, C., & Boilard, E. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00834-z · Cited by 81 · see citing works
Mitochondrial DNA: cellular genotoxic stress sentinel
Wu, Z., Sainz, A. G., & Shadel, G. S. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.05.004 · Cited by 83 · see citing works
Overcoming the pitfalls of merging dietary metabarcoding into ecological networks
Cuff, J. P., Windsor, F. M., Tercel, M. P. T. G., Kitson, J. J. N., & Evans, D. M. (2021) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.13796 · Cited by 89 · see citing works
Mitochondrial heterogeneity in diseases
Chen, L., Zhou, M., Li, H., Liu, D., Liao, P., Yao, Z., Zhang, C., Zou, W., & Gao, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01546-w · Cited by 85 · see citing works
The problem of omnivory: A synthesis on omnivory and DNA metabarcoding
Tercel, M. P. T. G., Symondson, W. O. C., & Cuff, J. P. (2021) · Molecular Ecology · doi:10.1111/mec.15903 · Cited by 80 · see citing works
Recent advances in management of COVID-19: A review
Mouffak, S., Shubbar, Q., Saleh, E., & El‐Awady, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112107 · Cited by 81 · see citing works
Mitochondrial DNA Copy Number and Risk of Oral Cancer: A Report from Northeast India
Mondal, R., Ghosh, S. K., Choudhury, J. H., Singh, S. A., Sinha, K., Hussain, M., Laskar, R. S., Rabha, B., Dey, P., Ganguli, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057771 · Cited by 78 · see citing works
Mitochondrial alterations in photodynamic therapy-resistant cells.
Sharkey, S., Wilson, B. C., Moorehead, R. A., & Singh, G. (1993) · PubMed · Cited by 75 · see citing works
Self-citationThe Fate of Human Sperm-Derived mtDNA in Somatic Cells
Manfredi, G., Thyagarajan, D. E., Papadopoulou, L. C., Pallotti, F., & Schon, E. A. (1997) · The American Journal of Human Genetics · doi:10.1086/514887 · Cited by 74 · see citing works
Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis
Pyle, A., Burn, D. J., Gordon, C., Swan, C., Chinnery, P. F., & Baudouin, S. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1823-7 · Cited by 70 · see citing works
Chen, S., Xie, X., Wang, Y., Gao, Y., Xie, X., Yang, J., & Ye, J. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.08.051 · Cited by 70 · see citing works
Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives
D’Amato, M., Morra, F., Meo, I. D., & Tiranti, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031969 · Cited by 70 · see citing works
Botero-Castro, F., Tilak, M., Justy, F., Catzeflis, F. M., Delsuc, F., & Douzery, E. (2013) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2013.07.003 · Cited by 68 · see citing works
Mutational patterns in the breast cancer mitochondrial genome, with clinical correlates
McMahon, S., & LaFramboise, T. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu012 · Cited by 68 · see citing works
Association between mitochondrial DNA content in leukocytes and colorectal cancer risk
Qu, F., Liu, X., Zhou, F., Yang, H., Bao, G., He, X., & Xing, J. (2011) · Cancer · doi:10.1002/cncr.25906 · Cited by 67 · see citing works
Mitochondrial integrity in neurodegeneration
Cowan, K., Anichtchik, O. V., & Luo, S. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13105 · Cited by 65 · see citing works
The Multiple Levels of Mitonuclear Coregulation
Isaac, R. S., McShane, E., & Churchman, L. S. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031709 · Cited by 65 · see citing works
Reduced oxidative stress increases acute cold stress tolerance in zebrafish
Lu, D., Ma, Q., Sun, S.-X., Zhang, H., Chen, L., Zhang, M., & Du, Z. (2019) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2019.06.009 · Cited by 63 · see citing works
Mitochondrial content of choroid plexus epithelium
Cornford, E. M., Varesi, J. B., Hyman, S., Damian, R. T., & Raleigh, M. J. (1997) · Experimental Brain Research · doi:10.1007/pl00005768 · Cited by 63 · see citing works
Aiken, C., Cindrová‐Davies, T., & Johnson, M. H. (2008) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60409-9 · Cited by 60 · see citing works
Organ reserve, excess metabolic capacity, and aging
Atamna, H., Tenore, A., Lui, F., & Dhahbi, J. M. (2018) · Biogerontology · doi:10.1007/s10522-018-9746-8 · Cited by 60 · see citing works
Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment.
Lamson, D. W., & Plaza, S. M. (2002) · PubMed · Cited by 57 · see citing works
Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis
Shaw, T., & LOCARNINI, S. A. (1995) · Liver International · doi:10.1111/j.1600-0676.1995.tb00667.x · Cited by 54 · see citing works
Skeletal Muscle Nucleo-Mitochondrial Crosstalk in Obesity and Type 2 Diabetes
Devarshi, P. P., McNabney, S. M., & Henagan, T. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040831 · Cited by 55 · see citing works
The alterations of mitochondrial DNA in coronary heart disease
Hu, H., Lin, Y., Xu, X., Lin, S., Chen, X., & Wang, S. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104412 · Cited by 51 · see citing works
Characterization of Myelin Sheath FoF1-ATP Synthase and its Regulation by IF1
Ravera, S., Panfoli, I., Aluigi, M. G., Calzia, D., & Morelli, A. M. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9112-1 · Cited by 50 · see citing works
Campa, D., Barrdahl, M., Santoro, A., Severi, G., Baglietto, L., Omichessan, H., Tumino, R., Bueno-de-Mesquita, H. B., Peeters, P. H. M., Weiderpass, E., et al. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0955-5 · Cited by 50 · see citing works
Sun, S., Guo, Z., Fu, H., Zhu, J. X., & Ge, X. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.072 · Cited by 49 · see citing works
Observation Bias in Metabarcoding
Shaffer, M., Allan, E. A., Cise, A. M. V., Parsons, K. M., Shelton, A. O., & Kelly, R. P. (2025) · Molecular Ecology Resources · doi:10.1111/1755-0998.14119 · Cited by 51 · see citing works
Tricarboxylic acid cycle-sustained oxidative phosphorylation in isolated myelin vesicles
Ravera, S., Bartolucci, M., Calzia, D., Aluigi, M. G., Ramoino, P., Morelli, A. M., & Panfoli, I. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.003 · Cited by 47 · see citing works
Kirstein, J., & Morimoto, R. I. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22292 · Cited by 49 · see citing works
He, Y., Lu, X., Wu, H., Cai, W., Yang, L.-Q., Xu, L., Sun, H., & Kong, Q. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.015 · Cited by 46 · see citing works
Imaging cell morphology and physiology using X-rays
Weinhardt, V., Chen, J.-H., Ekman, A. A., McDermott, G., Gros, M. A. L., & Larabell, C. A. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180036 · Cited by 45 · see citing works
Counting with DNA in metabarcoding studies: how should we convert sequence reads to dietary data?Preprint
Deagle, B. E., Thomas, A. C., McInnes, J. C., Clarket, L. J., Vesterinen, E. J., Clare, E. L., Kartzinel, T. R., & Eveson, J. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/303461 · Cited by 45 · see citing works
Hamblet, N. S., & Castora, F. J. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00158-9 · Cited by 44 · see citing works
Xie, H., Lev, D. C., Gong, Y. Y., Wang, S., Pollock, R. E., Wu, X., & Gu, J. H. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt023 · Cited by 44 · see citing works
Margaryan, A., Noer, C. L., Richter, S. R., Restrup, M. E. M., Bülow‐Hansen, J. L., Leerhøi, F., Langkjær, E., Gopalakrishnan, S., Carøe, C., Gilbert, M. T. P., et al. (2020) · Environmental DNA · doi:10.1002/edn3.138 · Cited by 43 · see citing works
Tissue specific and developmental expression of rat long-and medium-chain acyl-CoA dehydrogenases
Hainline, B. E., Kahlenbeck, D. J., Grant, J., & Strauss, A. W. (1993) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(93)90015-6 · Cited by 43 · see citing works
Hypothesis of an Energetic Function for Myelin
Morelli, A. M., Ravera, S., & Panfoli, I. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9174-8 · Cited by 41 · see citing works
Lebedeva, M. A., & Shadel, G. S. (2007) · Cell Cycle · doi:10.4161/cc.6.16.4572 · Cited by 40 · see citing works
Photobiomodulation: Evolution and Adaptation
Lipko, N. B. (2022) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2021.0145 · Cited by 37 · see citing works
Pozzi, A., & Dowling, D. K. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz132 · Cited by 38 · see citing works
Mitochondrial DNA Copy Number in Peripheral Blood and Melanoma Risk
Shen, J., Gopalakrishnan, V., Lee, J. E., Fang, S., & Zhao, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131649 · Cited by 38 · see citing works
Baek, J. H., Son, H., Jeong, Y., Park, S. W., & Kim, H. J. (2019) · Cells · doi:10.3390/cells8030247 · Cited by 36 · see citing works
Mitochondrial DNA homeostasis impairment and dopaminergic dysfunction: A trembling balance
Manini, A., Abati, E., Comi, G. P., Corti, S. P., & Ronchi, D. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101578 · Cited by 36 · see citing works
Sequence polymorphisms within the human mitochondrial genes MTATP6, MTATP8 and MTND4
Lutz‐Bonengel, S., Schmidt, U. G., Schmitt, T., & Pollak, S. (2003) · International Journal of Legal Medicine · doi:10.1007/s00414-002-0356-1 · Cited by 35 · see citing works
Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort
Gentiluomo, M., Katzke, V. A., Kaaks, R., Tjønneland, A. M., Severi, G., Perduca, V., Boutron‐Ruault, M., Weiderpass, E., Ferrari, P., Johnson, T., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0868 · Cited by 34 · see citing works
Mitochondrial biogenesis in rabbit articular chondrocytes transferred to culture
Mignotte, F., Champagne, A., Froger‐Gaillard, B., Benel, L., Guéride, M., Adolphe, M., & Mounolou, J. (1991) · Biology of the Cell · doi:10.1016/0248-4900(91)90052-o · Cited by 34 · see citing works
Zhu, X., Mao, Y., Huang, T., Yan, C., Yu, F., Du, J., Dai, J., Ma, H., & Jin, G. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22703 · Cited by 32 · see citing works
Xia, C., Liu, Y., Yang, H., Yang, H., Liu, J., Ma, Y., & Qi, Y. (2017) · Chinese Medical Journal · doi:10.4103/0366-6999.216395 · Cited by 32 · see citing works
Tu, H., Gu, J. H., Meng, Q. H., Kim, J., Davis, J. W., He, Y., Wagar, E. A., Thompson, T. C., Logothetis, C. J., & Wu, X. (2015) · Oncotarget · doi:10.18632/oncotarget.5889 · Cited by 31 · see citing works
Yang, W., Wu, J., Bi, A., Ou-yang, Y.-C., Shen, H., Chirn, G., Zhou, J., Weiss, E., Holman, E. P., & Liao, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077016 · Cited by 31 · see citing works
Mitofusin 2: A link between mitochondrial function and substrate metabolism?
Emery, J., & Ortiz, R. M. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.003 · Cited by 32 · see citing works
Schulz, S., Lichtmannegger, J., Schmitt, S., Leitzinger, C., Eberhagen, C., Einer, C., Kerth, J., Aichler, M., & Zischka, H. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2550-6_7 · Cited by 28 · see citing works
Functional Expression of Electron Transport Chain and FoF1-ATP Synthase in Optic Nerve Myelin Sheath
Bartolucci, M., Ravera, S., Garbarino, G., Ramoino, P., Ferrando, S., Calzia, D., Candiani, S., Morelli, A. M., & Panfoli, I. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1712-0 · Cited by 29 · see citing works
Zhao, S., Yang, Y., Liu, J., Liu, H., Ge, N., Yang, H., Zhang, H., & Xing, J. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01968.x · Cited by 29 · see citing works
Difficulties barcoding in the dark: the case of crustacean stygofauna from eastern Australia
Asmyhr, M. G., & Cooper, S. J. (2012) · Invertebrate Systematics · doi:10.1071/is12032 · Cited by 29 · see citing works
Granquist, S. M., Esparza‐Salas, R., Hauksson, E., Karlsson, O., & Angerbjörn, A. (2018) · Polar Biology · doi:10.1007/s00300-018-2354-x · Cited by 29 · see citing works
Müller-Nedebock, A. C., Brennan, R. R., Venter, M., Pienaar, I. S., van der Westhuizen, F. H., Elson, J. L., Ross, O. A., & Bardien, S. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104495 · Cited by 29 · see citing works
Mitochondrial DNA deletion and sarcopenia
Shah, V. O., Scariano, J., Waters, D. L., Qualls, C., Morgan, M., Pickett, G., Gasparovic, C., Dokładny, K., Moseley, P. L., & Raj, D. S. (2009) · Genetics in Medicine · doi:10.1097/gim.0b013e31819307a2 · Cited by 28 · see citing works
Extramitochondrial energy production in platelets
Ravera, S., Signorello, M. G., Bartolucci, M., Ferrando, S., Manni, L., Caicci, F., Calzia, D., Panfoli, I., Morelli, A. M., & Leoncini, G. (2018) · Biology of the Cell · doi:10.1111/boc.201700025 · Cited by 28 · see citing works
D-loop mutations in mitochondrial DNA: link with mitochondrial DNA depletion?
Barthélémy, C., de Baulny, H. O., & Lombès, A. (2002) · Human Genetics · doi:10.1007/s00439-002-0708-4 · Cited by 28 · see citing works
Wei, Y., & Kao, S. (2000) · Zoological studies · Cited by 27 · see citing works
- Authors
- Veltri, K. L., Espiritu, M., & Singh, G.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Singh, Gurmit
- ORCID
- Singh, Gurmit
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 143
- Issue
- 1
- Pages
- 160-164
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2030868673
- Cited by
- 242
- References
- 19
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 17 · 2022: 9 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 6
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McMaster University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial density, mitochondrial DNA copy number, mouse organs, liver, kidney, heart, brain, stereology
- MeSH terms
- Animals, Brain, DNA, Mitochondrial, Kidney, Mice, Inbred C57BL, Microscopy, Electron, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review