The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation
Abstract
Tissue inhibitor of metalloproteinase‐2 (TIMP‐2), a protease inhibitor that binds to the latent and active forms of 72 kDa type IV collagenase (gelatinase A), was found to inhibit the in vitro proliferation of human microvascular endothelial (HME) cells stimulated with bFGF and 5% serum. The maximal inhibitory effect of TIMP‐2 on incorporation of 3 H‐thymidine was evident 24 hours after bFGF stimulation of these cells and ranged between 45 and 60%. The half‐maximal effective concentration of TIMP‐2 was 107 ± 12 nM (S.D.). In contrast, TIMP‐1 was not found to slow the growth of HME cells. The inhibition of cell proliferation observed with TIMP‐2 was not mimicked by addition to the culture medium of BB94, a general matrix metalloproteinase inhibitor, nor antibodies to the 72 kDa type IV collagenase. In addition to growth, two other cell functions associated with the angiogenic process were tested for sensitivity to TIMP‐2. Cell adhesion to tissue culture platic was slightly stimulated by TIMP‐2, and cell migration was inhibited with short‐term exposure to TIMP‐2, but neither process was affected by longer‐term exposure. The ability of TIMP‐2 to inhibit cultured endothelial cell proliferation independent of protease inhibitory activity suggests that TIMP‐2 may have additional actions which may limit neovascularization associated with solid tumor growth and metastasis in vivo. © 1993 Wiley‐Liss, Inc.
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Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
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Tissue Inhibitor of Metalloproteinase (TIMP-2)
Stetler-Stevenson, W. G., Krutzsch, H. C., & Liotta, L. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71503-2 · Cited by 895
Self-citationTumor invasion through the human amniotic membrane: Requirement for a proteinase cascade
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Cited by
Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575
Tissue inhibitors of metalloproteinases: evolution, structure and function
Brew, K., Dinakarpandian, D., & Nagase, H. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(99)00279-4 · Cited by 1,908
Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M., & Werb, Z. (1998) · Cell · doi:10.1016/s0092-8674(00)81169-1 · Cited by 1,750
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
Liu, Z.-L., Chen, H.-H., Zheng, L.-L., Sun, L.-P., & Shi, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01460-1 · Cited by 1,300
Angiogenesis and Tumor Metastasis
Zetter, B. R. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.407 · Cited by 1,015
Metadata
- Authors
- Murphy, A. N., Unsworth, E. J., & Stetler‐Stevenson, W. G.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1993-11
- Volume
- 157
- Issue
- 2
- Pages
- 351-358
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2064623632
- Cited by
- 351
- References
- 40
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murphy, A. N., Unsworth, E. J., & Stetler‐Stevenson, W. G. (1993). Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1041570219
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