DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803 · see citing works

Stat3 as an Oncogene

Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155 · see citing works

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works

Gp130 and the interleukin-6 family of cytokines.

Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,603 · see citing works

Living on a break: cellular senescence as a DNA-damage response

d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170 · see citing works

The role of IL-6 and STAT3 in inflammation and cancer.

Hodge, D., Hurt, E. M., & Farrar, W. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.016 · Cited by 991 · see citing works

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

Bollrath, J., Phesse, T. J., von Burstin, V. A., Putoczki, T., Bennecke, M., Bateman, T., Nebelsiek, T., Lundgren-May, T., Canli, Ö., Schwitalla, S., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.002 · Cited by 946 · see citing works

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Sansone, P., Storci, G., Tavolari, S., Guarnieri, T., Giovannini, C., Taffurelli, M., Ceccarelli, C., Santini, D., Paterini, P., Marcu, K. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32533 · Cited by 779 · see citing works

The Stat family in cytokine signaling

Ihle, J. N. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00199-x · Cited by 713 · see citing works

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Gao, S. P., Mark, K. G., Leslie, K., Pao, W., Motoi, N., Gerald, W. L., Travis, W. D., Bornmann, W., Veach, D., Clarkson, B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31871 · Cited by 666 · see citing works

Initiating Cellular Stress Responses

Bakkenist, C. J., & Kastan, M. B. (2004) · Cell · doi:10.1016/j.cell.2004.06.023 · Cited by 544 · see citing works

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515 · see citing works

DNA Damage-Mediated Induction of a Chemoresistant Niche

Gilbert, L. A., & Hemann, M. T. (2010) · Cell · doi:10.1016/j.cell.2010.09.043 · Cited by 428 · see citing works

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis

Ancrile, B., Lim, K.-H., & Counter, C. M. (2007) · Genes & Development · doi:10.1101/gad.1549407 · Cited by 422 · see citing works

Interleukin‐6 and its receptor in cancer: Implications for Translational Therapeutics

Hong, D. S., Angelo, L. S., & Kurzrock, R. (2007) · Cancer · doi:10.1002/cncr.22999 · Cited by 370 · see citing works

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

Sugrue, M. M., Shin, D. Y., Lee, S. W., & Aaronson, S. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9648 · Cited by 290 · see citing works

Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction (*)

Kaptein, A., Paillard, V., & Saunders, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.5961 · Cited by 264 · see citing works

PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress

Mabb, A. M., Wuerzberger‐Davis, S. M., & Miyamoto, S. (2006) · Nature Cell Biology · doi:10.1038/ncb1458 · Cited by 226 · see citing works

Activation of Transcription Factor NF-κB Requires ELKS, an IκB Kinase Regulatory Subunit

Sigala, J. L. D., Bottero, V., Young, D. B., Shevchenko, A., Mercurio, F., & Verma, I. M. (2004) · Science · doi:10.1126/science.1098387 · Cited by 220 · see citing works

Cytokine-Dependent Imatinib Resistance in Mouse Bcr-Abl(+), Arf-Null Lymphoblastic Leukemia.Preprint

Williams, R. T., den Besten, W., Boulos, N., & Sherr, C. J. (2007) · Genes & Development · doi:10.1101/gad.1588607 · Cited by 178 · see citing works

SUMO and NF-κB ties

Mabb, A. M., & Miyamoto, S. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7005-2 · Cited by 100 · see citing works

IL-6: From Laboratory to Bedside

Kishimoto, T. (2005) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:28:3:177 · Cited by 71 · see citing works

Overexpression of plasminogen activator inhibitor type‐1 in senescent fibroblasts from normal subjects and those with Werner syndrome

Goldstein, S., Moerman, E. J., Fujii, S., & Sobel, B. E. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041610321 · Cited by 59 · see citing works

Appearance of biomarkers of in vitro ageing after successive stimulation of WI‐38 fibroblasts with IL‐1α and TNF‐α: senescence associated β‐galactosidase activity and morphotype transition

DUMONT, P., BALBEUR, L., Remacle, J., & Toussaint, O. (2000) · Journal of Anatomy · doi:10.1046/j.1469-7580.2000.19740529.x · Cited by 54 · see citing works

Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage

Chae, H., Kim, B. M., Yun, U.-J., & Shin, D. Y. (2008) · Oncogene · doi:10.1038/onc.2008.46 · Cited by 22 · see citing works

Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation.

Jung, M., Jin, D., Chae, H., Kang, S., Kim, S., Bang, Y., Choi, T., Choi, K., & Shin, D. (2004) · AJOU Open Repository (Ajou University) · doi:10.1074/jbc.m305015200

Role of interleukin-6 in cancer progression and therapeutic resistance

Kumari, N., Dwarakanath, B. S. R., Das, A., & Bhatt, A. N. (2016) · Tumor Biology · doi:10.1007/s13277-016-5098-7 · Cited by 1,096 · see citing works

Secretion of immunoregulatory cytokines by mesenchymal stem cells

Kyurkchiev, D. S. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i5.552 · Cited by 619 · see citing works

Physiological and molecular determinants of embryo implantation

Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 592 · see citing works

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

Ferguson, L. R., Chen, H., Collins, A. R., Connell, M., Damia, G. L. M., Dasgupta, S., Malhotra, M., Meeker, A. K., Amedei, A., Amin, A., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.005 · Cited by 340 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

Li, W., Hu, X., Wang, S., Jiao, Z., Sun, T., Liu, T., & Song, K. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.189 · Cited by 279 · see citing works

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

Zhang, J., Dang, F., Ren, J., & Wei, W. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.09.004 · Cited by 229 · see citing works

Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma

Ebbing, E. A., van der Zalm, A. P., Steins, A., Creemers, A., Hermsen, S., Rentenaar, R., Klein, M., Waasdorp, C., Hooijer, G. K. J., Meijer, S. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820459116 · Cited by 183 · see citing works

IL-6-STAT3 signaling and premature senescence

Kojima, H., Inoue, T., Kunimoto, H., & Nakajima, K. (2013) · JAK-STAT · doi:10.4161/jkst.25763 · Cited by 170 · see citing works

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Burgess, J. K., Mutsaers, S. E., Prêle, C. M., Schuliga, M. J., Grainge, C., & Knight, D. A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00037.2018 · Cited by 167 · see citing works

Hesperidin inhibits lung fibroblast senescence via IL-6/STAT3 signaling pathway to suppress pulmonary fibrosis

Han, D., Gong, H., Wei, Y., Xu, Y., Zhou, X., Wang, Z., & Feng, F. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154680 · Cited by 118 · see citing works

Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy

Datta, R., Bansal, T., Rana, S., Datta, K., Chaudhuri, R. D., Chawla‐Sarkar, M., & Sarkar, S. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00611-16 · Cited by 114 · see citing works

Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Luan, Y., Zhu, X., Jiao, Y., Liu, H., Huang, Z., Pei, J., Xu, Y., Yang, Y., & Ren, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01792-5 · Cited by 106 · see citing works

DNA Damage and Pulmonary Hypertension

Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 105 · see citing works

The SASP factor IL ‐6 sustains cell‐autonomous senescent cells via a cGAS ‐ STING ‐ NFκB intracrine senescent noncanonical pathway

Herbstein, F., Sapochnik, M., Attorresi, A. I., Pollak, C., Senin, S. A., Gonilski‐Pacin, D., del Giudice, N. C., Fiz, M., Elguero, B., Fuertes, M., et al. (2024) · Aging Cell · doi:10.1111/acel.14258 · Cited by 101 · see citing works

Antitumor and immunomodulatory effects of a water-soluble polysaccharide from Lilii Bulbus in mice

Sun, X., Gao, R., Yao-kang, X., Huang, Q.-C., & Xu, M. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.12.002 · Cited by 92 · see citing works

Immune-enhancing effects of polysaccharides extracted from Lilium lancifolium Thunb

Pan, G., Xie, Z., Huang, S., Tai, Y., Cai, Q., Jiang, W., Sun, J., & Yuan, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.030 · Cited by 88 · see citing works

Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression

Yu, M., Bin, L., Liu, Y., Me, Y., Wang, L., & Zhang, P. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6065 · Cited by 69 · see citing works

Prognostic implication of TIM-3 in clear cell renal cell carcinoma

Yuan, J., Jiang, B., Zhao, H., & Huang, Q. B. (2013) · Neoplasma · doi:10.4149/neo_2014_006 · Cited by 68 · see citing works

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

Garbers, C., Kuck, F., Aparicio-Siegmund, S., Konzak, K., Kessenbrock, M., Sommerfeld, A., Häussinger, D., Lang, P. A., Brenner, D., Mak, T. W., et al. (2013) · Cell Cycle · doi:10.4161/cc.26431 · Cited by 64 · see citing works

Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice

Wang, Z., Yan, J., Lin, H., Hua, F., Wang, X., Liu, H., Lv, X., Yu, J., Mi, S., Wang, J., et al. (2013) · Hepatology · doi:10.1002/hep.26234 · Cited by 63 · see citing works

Structure and Antitumor and Immunomodulatory Activities of a Water-Soluble Polysaccharide from Dimocarpus longan Pulp

Meng, F., Ning, Y.-L., Jia, Q., He, Z., Jie, J., Lin, J., Huang, Y.-J., Li, F.-S., & Li, X. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15035140 · Cited by 61 · see citing works

Prognostic Value of T Cell Immunoglobulin Mucin-3 in Prostate Cancer

Piao, Y.-R., Piao, L., Zhu, L., Jin, Z., & Dong, X.-Z. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.6.3897 · Cited by 60 · see citing works

Helicobacter hepaticuscytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2-deficient mice

Ge, Z., Feng, Y., Ge, L., Parry, N. M., Muthupalani, S., & Fox, J. G. (2017) · Cellular Microbiology · doi:10.1111/cmi.12728 · Cited by 57 · see citing works

Human Bone Marrow-Derived Mesenchymal Stem Cells Promote the Growth and Drug-Resistance of Diffuse Large B-Cell Lymphoma by Secreting IL-6 and Elevating IL-17A Levels

Zhong, W., Zhu, Z., Xu, X., Zhang, H., Xiong, H., Li, Q., & Wei, Y. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1081-7 · Cited by 55 · see citing works

Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis

Igietseme, J. U., Omosun, Y., Stuchlik, O., Reed, M. S., Partin, J. V., He, Q., Joseph, K., Ellerson, D., Bollweg, B. C., George, Z., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145198 · Cited by 52 · see citing works

BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells

Js, L., Lee, J.-S., Cui, M. N., Yun, H. H., Kim, H. Y., Lee, S. H., & Lee, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.501 · Cited by 51 · see citing works

Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

Chen, L., Liu, P., Chen, Y., Tseng, H., Shen, P.-C., Hwang, P., & Hsu, H.-L. (2017) · Scientific Reports · doi:10.1038/s41598-017-12111-1 · Cited by 49 · see citing works

Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression

Chen, L., Tseng, H., Chen, Y., Haq, A. T. A., Hwang, P., & Hsu, H.-L. (2020) · Cancers · doi:10.3390/cancers12020421 · Cited by 42 · see citing works

Effect of Grifola frondosa polysaccharide on anti-tumor activity in combination with 5-Fu in Heps-bearing mice

Mao, G., Zhang, Z.-H., Fei, F., Ding, Y., Zhang, W., Chen, H., Ali, S. S., Zhao, T., Feng, W., Wu, X., et al. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.073 · Cited by 40 · see citing works

Programmed cell senescence: role of IL-6 in the pituitary

Sapochnik, M., Fuertes, M., & ARZT, E. S. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0026 · Cited by 37 · see citing works

Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment

Nehme, R., Hallal, R., Dor, M. E., Kobeissy, F. H., Gouilleux, F., Mazurier, F., & Zibara, K. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200908114411 · Cited by 34 · see citing works

On the significance of Tim-3 expression in pancreatic cancer

Peng, P., Li, Y., & Sun, S. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.006 · Cited by 29 · see citing works

Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer Cells

Al-Asmari, S. S., Rajapakse, A., Ullah, T. R., Pépin, G., Croft, L. V., & Gantier, M. P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.709618 · Cited by 28 · see citing works

C-reactive protein (CRP) promotes malignant properties in pancreatic neuroendocrine neoplasms

Schimmack, S., Yang, Y.-C., Felix, K., Herbst, M., Li, Y., Schenk, M., Bergmann, F., Hackert, T., & Strobel, O. (2019) · Endocrine Connections · doi:10.1530/ec-19-0132 · Cited by 21 · see citing works

DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling

Wheeler, O. P. G., & Unterholzner, L. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220241 · Cited by 26 · see citing works

ATM and p53 in aging and cancer: a double-edged sword in genomic integrity

Pandey, S. N., Afzal, M., Uikey, J., Ganesan, S., Mishra, S., Bansal, P., Kazmi, I. A., Alzarea, S. I., Almalk, W. H., Goyal, K., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10249-4 · Cited by 21 · see citing works

The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies

Liu, J., Zheng, R., Zhang, Y., Jia, S., He, Y., & Liu, J. (2023) · Cancers · doi:10.3390/cancers15092640 · Cited by 19 · see citing works

Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth

Khanna, A., Thoms, J. A. I., Stringer, B. W., Chung, S. A., Ensbey, K. S., Jue, T. R., Jahan, Z., Subramanian, S., Anande, G., Shen, H. M., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0934 · Cited by 19 · see citing works

A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.

Li, Z., Zhu, T., Xu, Y., Wu, C., Chen, J., Ren, Y., Kong, L., Sun, S., Guo, W., Wang, Y., et al. (2019) · PubMed Central · Cited by 18 · see citing works

Clinically relevant preservation conditions for mesenchymal stem/stromal cells derived from perinatal and adult tissue sources

Ngo, A. T., Hang, L. M., Nhung, T. T. H., Jun, A. P. G., Bach, T. Q., Bui, H. T. H., Hoang, V. T., Bui, A. V., Liêm, N. T., & Hoang, D. M. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17016 · Cited by 16 · see citing works

Heat Effect Induces Production of Inflammatory Cytokines Through Heat Shock Protein 90 Pathway in Cornea Cells

Tsai, M., Hsu, Y., Wu, K., Yang, R., Chen, Y., Yu, H., & Kuo, P. (2013) · Current Eye Research · doi:10.3109/02713683.2012.763103 · Cited by 17 · see citing works

Neuropilin-1 (NRP-1) upregulated by IL-6/STAT3 signaling contributes to invasion in pancreatic neuroendocrine neoplasms

Yang, Y., Yang, L., & Li, Y. (2018) · Human Pathology · doi:10.1016/j.humpath.2018.06.030 · Cited by 16 · see citing works

Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells

Houssein, M., Saab, W. F. A., Khalil, M. I. M., Khalife, H. K., & Fatfat, M. (2020) · Current Therapeutic Research · doi:10.1016/j.curtheres.2020.100589 · Cited by 15 · see citing works

Ibrutinib as a potential therapeutic option for HER2 overexpressing breast cancer – the role of STAT3 and p21

Prabaharan, C. B., Yang, A. B., Chidambaram, D., Rajamanickam, K., Napper, S., & Sakharkar, M. K. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00837-w · Cited by 15 · see citing works

Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts

Suzuki, K., Chosa, N., Sawada, S., Takizawa, N., Yaegashi, T., & Ishisaki, A. (2017) · Stem Cells International · doi:10.1155/2017/3296498 · Cited by 14 · see citing works

Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells

Hallal, R., Nehme, R., Brachet‐Botineau, M., Nehme, A., Dakik, H., Deynoux, M., Sbarba, P. D., Vern, Y. L., Zibara, K., Gouilleux, F., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15612 · Cited by 13 · see citing works

Fucoidan inhibits tooth movement by promoting restorative macrophage polarization through the STAT3 pathway

Zhang, S., Zhang, H., Jin, Z., Wang, S., Wang, Y., Zhu, L., Sun, W. S., & Yan, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29519 · Cited by 13 · see citing works

Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms

Yang, L., Yu, X., & Yang, Y. (2018) · Endocrine Connections · doi:10.1530/ec-18-0356 · Cited by 12 · see citing works

Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells

Hsu, H.-W., de Necochea-Campion, R., Williams, V. M., Duerksen-Hughes, P. J., Simental, A., Ferris, R. L., Chen, C.-S., & Mirshahidi, S. (2014) · Oral Oncology · doi:10.1016/j.oraloncology.2014.03.006 · Cited by 12 · see citing works

Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells

Li, L., Hu, X., Nkwocha, J., Sharma, K., Kmieciak, M., Mann, H., Zhou, L., & Grant, S. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00817-6 · Cited by 10 · see citing works

Quantification of Cytokines in Lip Tissue from Infants Affected by Congenital Cleft Lip and Palate

Pilmane, M., Jain, N., Jain, S., Akota, I., & Kroiča, J. (2021) · Children · doi:10.3390/children8020140 · Cited by 10 · see citing works

Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities

Olekšák, P., Rysanek, D., Vančurová, M., Vašicová, P., Urbancokova, A., Novak, J. F., Maurencova, D., Kashmel, P., Houserova, J., Mikyšková, R., et al. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00190 · Cited by 6 · see citing works

Novel radiation and targeted therapy combinations for improving rectal cancer outcomes

Pennel, K. A. F., Dutton, L. R., Melissourgou-Syka, L., Roxburgh, C. S. D., Birch, J. L., & Edwards, J. (2024) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2024.15 · Cited by 6 · see citing works

Analysis of Acanthopanax giraldii Harms Polysaccharide II Composition and Its Immune-Protective Role in a Cyclophosphamide-Induced Immunosuppressive Mice Model

Guo, X., Hao, H., Meng, A., Xu, C. J., Ma, Y., Sun, F., & Chen, Y. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/3387396 · Cited by 6 · see citing works

Cabozantinib Sensitizes NSCLC Cells to Radiation by Inducing Ferroptosis via STAT3/MCL1/BECN1/SLC7A11 Axis Suppression

Wang, C., Huang, C., Chen, L.-J., Chen, G., & Hong, S. (2025) · Cancers · doi:10.3390/cancers17182950 · Cited by 5 · see citing works

Targeting cytokine and chemokine signaling pathways for enhancing chemo-sensitivity in colorectal cancer

Li, S., Xie, M., Du, Y., & Tan, Z. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02235-7 · Cited by 5 · see citing works

New insights into the role of cellular senescence and rheumatic diseases

Wen, J., Li, J., Wan, L., & Wang, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1557402 · Cited by 4 · see citing works

Demethylation of SOCS1 mediates its abnormally high expression in ovarian cancer

Li, X., Kong, C., Fan, Y.-C., Liu, J., Lu, W., Meng, C., Li, A., Zhai, A., Yan, B., Song, W., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10451 · Cited by 4 · see citing works

Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2–STAT3, NF-κB, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions

Becerril, J. L. M., Benítez, J. G. S., Torres-Juárez, J. J., Bañales, J. M., Zerón, H. M., & Navarro, M. D. H. (2015) · Biochemical Genetics · doi:10.1007/s10528-015-9691-z · Cited by 3 · see citing works

Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells

Ge, J., Zhang, X., Wang, F., Wang, Y., Li, Q., Wei, T., & Ren, G. (2015) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2015.09.008 · Cited by 3 · see citing works

Decellularized Extracellular Matrix Produced by iPSC ‐Derived MSCs Promotes iPSC ‐ MSC Proliferation and Differentiation and Regulates Secreted Factors

Huang, T., Yang, M., Grant, C., Kelly, K., O’Connor, A. J., Kalionis, B., & Heath, D. E. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbma.70010 · Cited by 2 · see citing works

Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment

Nehme, R. (2021) · Current Medicinal Chemistry · doi:10.2174/1875533xmta5enzg5y · Cited by 2 · see citing works

Novel rectal cancer spheroid models reveal metabolic and transcriptional adaptations driving radiotherapy response

Estêvão, D., da Cruz-Ribeiro, M., Canha‐Borges, A., Macedo‐Silva, C., Castro, F., Lencart, J., Boterberg, T., Sousa, O., Jerónimo, C., Duarte, I. F., et al. (2025) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2025.111288 · Cited by 1 · see citing works

Deciphering the genotype and phenotype of hairy cell leukemia: clues for diagnosis and treatment

Polderdijk, M. C. E., Heron, M., Kuipers, S., & Rijkers, G. T. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1641405 · Cited by 1 · see citing works

Potential Mechanisms Linking Oxidized LDL to Susceptibility to Cancer

Khaidakov, M., & Mehta, J. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-5857-9_19

Investigating the interactions between nonoparticles and UV-irradiated HaCaT keratinocytes

Patsikatheodorou, N. (2014) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27333276

Az interleukin-6-expresszió vizsgálata colorectalis adenocarcinomában szenvedő betegeken

Jósa, V., Féderer, K., Zrubka, Z., Reiniger, L., & Baranyai, Z. (2021) · Orvosi Hetilap · doi:10.1556/650.2021.32206

L'effet immunomodulateur de cellule souche mésenchymateuse et ses exosomes sur l'activité des lymphocytes

Fan, Y. (2017) · doi:10.70675/851621d8z6636z44d0zb0acz11d01cf839bb

Abstract 3138: IL-6/Stat3 signaling is an indispensable modulator of oncogene-induced cellular senescence

Pěnčík, J., Schlederer, M., Hassler, M. R., Gruber, W., Aberger, F., Kennedy, R. D., Walker, S., Rose‐John, S., Poli, V., Eferl, R., et al. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-3138

IL-6-STAT3 signaling and premature senescence

Kojima, H., Inoue, T., Kunimoto, H., & Nakajima, K. (2013) · JAK-STAT · doi:10.4161/jkst.25763 · Cited by 170 · see citing works

Interleukin-6 Induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5

Kojima, H., Kunimoto, H., Inoue, T., & Nakajima, K. (2013) · Springer eBooks · doi:10.1007/978-94-007-7726-2_6

DNA damage and signalling pathways in cellular senescence

Hubáčková, S. (2012) · Digital Repository (National Repository of Grey Literature)

IL-6 Activities in the Tumour Microenvironment. Part 1

Chonov, D. C., Ignatova, M., Ananiev, J. R., & Gulubova, M. V. (2019) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2019.589 · Cited by 115 · see citing works