The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Functional regulation of HIF‐1α under normoxia—is there more than post‐translational regulation?
Abstract
The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional activator playing a pivotal role in mammalian physiology and disease pathogenesis, e.g., HIF‐1 is indispensable in a broad range of developmental stages in different tumors. Its post‐translational regulation via PHDs under the influence of hypoxia is widely investigated and accepted. Different non‐hypoxic stimuli such as lipopolysaccharides (LPS), thrombin, and angiotensin II (Ang II), have been proven to enhance HIF‐1 levels through activation of regulative mechanisms distinct from protein stabilization. Some of these stimuli specifically regulate HIF‐1α at the transcriptional, post‐transcriptional, or translational level, whereas others additionally influence post‐translational modifications. Thus, it is difficult for the investigators to discern the impact of the different mechanisms leading to functional HIF‐1 protein. Nevertheless, profound knowledge of additional regulatory networks appears to depict new therapeutic opportunities and thus is an interesting and important field for further investigations. J. Cell. Physiol. 227: 514–524, 2012. © 2011 Wiley Periodicals, Inc.
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Unravelling cancer stem cell potential
Beck, B., & Blanpain, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3597 · Cited by 905
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
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Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Wu, Q., You, L., Nepovimova, E., Heger, Z., Wu, W., Kuca, K., & Adam, V. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01292-6 · Cited by 485
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Mechanisms of hypoxia signalling: new implications for nephrology
Schödel, J., & Ratcliffe, P. J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0182-z · Cited by 309
Metadata
- Authors
- Kuschel, A., Simon, P., & Tug, S.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2011-11-23
- Volume
- 227
- Issue
- 2
- Pages
- 514-524
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2040766980
- Cited by
- 171
- References
- 17
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
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