Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms
Abstract
Endometriosis refers to a benign chronic gynecological disorder, and is defined as the ectopic growth of endometrium in pelvic cavity. Endometriosis affects about 10% of reproductive-aged women. Unfortunately, the pathogenesis of endometriosis remains obscure, and the disease witnesses a lack of effective therapy approaches. Therefore, more research needs to be performed to throw light on endometriosis, its pathogenesis, and therapy. Long noncoding RNAs (lncRNAs), which are defined as functional cellular RNA longer than 200 nucleotides, have been implicated in many chronic disorders. It has been suggested that lncRNAs are closely related to the endometriosis process. Nevertheless, the molecular mechanisms by which lncRNAs associate with endometriosis should be elucidated more detailed. In our brief review, we first exhibit the aberrant lncRNAs expression in endometriosis. Then, we talk about the molecular mechanisms underlying lncRNAs in endometriosis. Finally, we also present the potential of lncRNAs as biomarkers for endometriosis.
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lncRNAs show potential as biomarkers of endometriosis.
“In summary, lncRNAs show potential as biomarkers of endometriosis [176].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [176]
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- Authors
- Wang, X., Zhang, J., Liu, X., Wei, B., & Zhan, L.
- Affiliations
- Anhui Provincial Children's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Corresponding author
- Wei, Bing
- Zhan, Lei
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2020-06-07
- Volume
- 236
- Issue
- 1
- Pages
- 6-14
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W3034082461
- Cited by
- 24
- References
- 75
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 3
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81802586)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, long non-coding RNA, lncRNA expression, endometriosis pathogenesis, therapeutic target
- MeSH terms
- Animals, Endometriosis, Endometrium, Female, Humans, Biomarkers, Gene Expression, RNA, Long Noncoding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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