Cited by 24Endometriosis Research and TreatmentCancer-related molecular mechanisms researchEctopic Pregnancy Diagnosis and Management

Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms

Wang, Xu, Zhang, Jing, Liu, Xiaojing, Wei, Bing, Zhan, Lei·2021·Journal of Cellular Physiology

Abstract

Endometriosis refers to a benign chronic gynecological disorder, and is defined as the ectopic growth of endometrium in pelvic cavity. Endometriosis affects about 10% of reproductive-aged women. Unfortunately, the pathogenesis of endometriosis remains obscure, and the disease witnesses a lack of effective therapy approaches. Therefore, more research needs to be performed to throw light on endometriosis, its pathogenesis, and therapy. Long noncoding RNAs (lncRNAs), which are defined as functional cellular RNA longer than 200 nucleotides, have been implicated in many chronic disorders. It has been suggested that lncRNAs are closely related to the endometriosis process. Nevertheless, the molecular mechanisms by which lncRNAs associate with endometriosis should be elucidated more detailed. In our brief review, we first exhibit the aberrant lncRNAs expression in endometriosis. Then, we talk about the molecular mechanisms underlying lncRNAs in endometriosis. Finally, we also present the potential of lncRNAs as biomarkers for endometriosis.

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Crossref · 10.1002/jcp.29847

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Authors
Wang, X., Zhang, J., Liu, X., Wei, B., & Zhan, L.
Affiliations
  • Anhui Provincial Children's Hospital (CN)
  • Second Affiliated Hospital of Anhui Medical University (CN)
  • First Affiliated Hospital of Anhui Medical University (CN)
Corresponding author
  • Wei, Bing
  • Zhan, Lei
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
2020-06-07
Volume
236
Issue
1
Pages
6-14
ISSN
  • 0021-9541 (ISSN-L)
  • 1097-4652
OpenAlex
W3034082461
Cited by
24
References
75
Citations by year
2025: 5 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 3
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cellular Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81802586)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, long non-coding RNA, lncRNA expression, endometriosis pathogenesis, therapeutic target
MeSH terms
Animals, Endometriosis, Endometrium, Female, Humans, Biomarkers, Gene Expression, RNA, Long Noncoding

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