Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration

Epidemiology of insomnia: what we know and what we still need to learn

Ohayon, M. M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0186 · Cited by 3,743 · cited 2× · see citing works

Sex Differences in Insomnia: A Meta-Analysis

Zhang, B., & Wing, Y.-K. (2006) · Sleep · doi:10.1093/sleep/29.1.85 · Cited by 1,286 · see citing works

Sex Differences in Pharmacokinetics and Pharmacodynamics

Gandhi, M., Aweeka, F. T., Greenblatt, R. M., & Blaschke, T. F. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121453 · Cited by 546 · see citing works

Gender differences in sleep disorders

Krishnan, V., & Collop, N. A. (2006) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000245705.69440.6a · Cited by 497 · see citing works

Gender differences in drug responses

Franconi, F., Brunelleschi, S., Steardo, L., & Cuomo, V. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.11.001 · Cited by 464 · see citing works

Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans

Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I. (1997) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1997.tb04356.x · Cited by 387 · see citing works

The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates

Cotreau, M. M., Moltke, L. L., & Greenblatt, D. J. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544010-00002 · Cited by 291 · see citing works

Insomnia Symptoms in Older Adults: Associated Factors and Gender Differences

Jaussent, I., Dauvilliers, Y., Ancelin, M.-L., Dartigues, J.-F., Tavernier, B., Touchon, J., Ritchie, K., & Besset, A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e049b6 · Cited by 286 · see citing works

Zolpidem for insomnia

Greenblatt, D. J., & Roth, T. G. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.667074 · Cited by 284 · see citing works

Clinical Pharmacokinetics and Pharmacodynamics of Zolpidem

Salvà, P., & Costa, J. (1995) · Clinical Pharmacokinetics · doi:10.2165/00003088-199529030-00002 · Cited by 273 · see citing works

The Current State of Knowledge on Age, Sex, and Their Interactions on Clinical Pharmacology

Schwartz, J. B. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100226 · Cited by 256 · see citing works

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole.

Moltke, L. L., Greenblatt, D. J., Harmatz, J. S., Duan, S., Harrel, L., Cotreau-Bibbo, M. M., Pritchard, G. A., Wright, C. E., & Shader, R. I. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12284-2 · Cited by 225 · see citing works

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

Moltke, L. L., Greenblatt, D. J., Granda, B. W., Duan, S. X., Grassi, J. M., Venkatakrishnan, K., Harmatz, J. S., & Shader, R. I. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00953.x · Cited by 133 · see citing works

Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation of Sex-Dependent Differences

Greenblatt, D. J., Harmatz, J. S., Moltke, L. L., Wright, C. E., Durol, A. L. B., Harrel-Joseph, L. M., & Shader, R. I. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39253-5 · Cited by 123 · see citing works

Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo*

Greenblatt, D. J., Harmatz, J. S., Moltke, L. L., Ehrenberg, B. L., Harrel, L., Corbett, K., Counihan, M., Graf, J. A., Darwish, M., Mertzanis, P., et al. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90139-4 · Cited by 115 · see citing works

Sedative, memory, and performance effects of hypnotics

Roehrs, T., Merlotti, L. A., Zorick, F. J., & Roth, T. G. (1994) · Psychopharmacology · doi:10.1007/bf02245054 · Cited by 113 · see citing works

Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs

Greenblatt, D. J., & Moltke, L. L. (2008) · The Journal of Clinical Pharmacology · doi:10.1177/0091270008323754 · Cited by 112 · see citing works

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men

Olubodun, J. O., Ochs, H. R., Von Moltke, L. L., Roubenoff, R., Hesse, L. M., Harmatz, J. S., Shader, R. I., & Greenblatt, D. J. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2003.01852.x · Cited by 104 · see citing works

Pencil and paper tests‐sensitivity to psychotropic drugs.

Stone, B. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb02578.x · Cited by 104 · see citing works

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate

GREENBLATT, D., HARMATZ, J., VONMOLTKE, L., WRIGHT, C., & SHADER, R. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.07.009 · Cited by 93 · see citing works

Pharmacokinetic-Pharmacodynamic Relationships For Benzodiazepines

Laurijssens, B. E., & Greenblatt, D. J. (1996) · Clinical Pharmacokinetics · doi:10.2165/00003088-199630010-00004 · Cited by 93 · see citing works

Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: Kinetic-dynamic studies

Greenblatt, D. J., Harmatz, J. S., Gouthro, T. A., Locke, J., & Shader, R. I. (1994) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1994.106 · Cited by 59 · see citing works

Imidazopyridines in sleep disorders : a novel experimental and therapeutic approach

Sauvanet, J.-P., Langer, S. Z., Morselli, P. L., & Synthelabo, L. D. E. D. R. (1988) · Raven Press eBooks · Cited by 58 · see citing works

Dynamics and Kinetics of a Modified‐Release Formulation of Zolpidem: Comparison With Immediate‐Release Standard Zolpidem and Placebo

Greenblatt, D. J., Legangneux, E., Harmatz, J. S., Weinling, E., Freeman, J., Rice, K., & Zammit, G. K. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006293303 · Cited by 57 · see citing works

Low-Dose Sublingual Zolpidem Tartrate is Associated with Dose-Related Improvement in Sleep Onset and Duration in Insomnia Characterized by Middle-of-the-Night (MOTN) Awakenings

Roth, T. G., Hull, S. G., Lankford, D. A., Rosenberg, R. P., Scharf, M. B., Intermezzo Study Group, Nikhilesh Singh, P., Jenny Novack, B., Murray Maytom, M., Yu Ping Maguire, P., et al. (2008) · SLEEP · doi:10.5665/sleep/31.9.1277 · Cited by 56 · see citing works

Sleep Disorders in Women: Clinical Evidence and Treatment Strategies

Soares, C. N., & Murray, B. J. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.09.002 · Cited by 55 · see citing works

Sedative effects and impaired learning and recall after single oral doses of lorazepam

Shader, R. I., Dreyfuss, D. A., Gerrein, J. R., Harmatz, J. S., Allison, S. J., & Greenblatt, D. J. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.90 · Cited by 51 · see citing works

Novel Sublingual Low-Dose Zolpidem Tablet Reduces Latency to Sleep Onset following Spontaneous Middle-of-the-Night Awakening in Insomnia in a Randomized, Double-Blind, Placebo-Controlled, Outpatient Study

Roth, T. G., Krystal, A. D., Steinberg, F. J., Singh, N., & Moline, M. L. (2013) · SLEEP · doi:10.5665/sleep.2370 · Cited by 48 · see citing works

Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults

Greenblatt, D. J., Harmatz, J. S., Roth, T. G., Singh, N., Moline, M. L., Harris, S., & Kapil, R. P. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.03.007 · Cited by 43 · see citing works

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

Chetty, M., Mattison, D. R., & Rostami‐Hodjegan, A. (2012) · Current Drug Metabolism · doi:10.2174/138920012800840464 · Cited by 43 · see citing works

Gender Differences in Highway Driving Performance After Administration of Sleep Medication: A Review of the Literature

Verster, J. C., & Roth, T. (2012) · Traffic Injury Prevention · doi:10.1080/15389588.2011.652751 · Cited by 41 · see citing works

Psychotropic Drug Prescribing in the United States

Greenblatt, D. J., Harmatz, J. S., & Shader, R. I. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318209cf05 · Cited by 36 · see citing works

Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test

Greenblatt, D. J., Gan, L., Harmatz, J. S., & Shader, R. I. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02409.x · Cited by 33 · see citing works

Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications

Greenblatt, D. J., & Zammit, G. K. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.741588 · Cited by 28 · see citing works

Fatigue, insomnia and nervousness: gender disparities and roles of individual characteristics and lifestyle factors among economically active people

The Lorhandicap Group, Peretti‐Watel, P., Legleye, S., Baumann, M., Choquet, M., Falissard, B., & Chau, N. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-008-0487-x · Cited by 27 · see citing works

Daytime pharmacodynamic and pharmacokinetic evaluation of low‐dose sublingual transmucosal zolpidem hemitartrate

Roth, T. G., Mayleben, D. W., Corser, B. C., & Singh, N. (2007) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.884 · Cited by 27 · see citing works

Kinetic-Dynamic Modeling in Clinical

Greenblatt, D. J., & Harmatz, J. S. (1993) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199308000-00001 · Cited by 14 · see citing works

Sublingual zolpidem tartrate lozenge for the treatment of insomnia

Lankford, A. (2009) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.09.15 · Cited by 7 · see citing works

Digit Symbol Substitution Test: The Case for Sensitivity Over Specificity in Neuropsychological Testing

Jaeger, J. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000941 · Cited by 836 · see citing works

Sex differences in pharmacokinetics predict adverse drug reactions in women

Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777 · see citing works

Sex and gender differences research design for basic, clinical, and population studies: essentials for investigators

Rich-Edwards, J. W., Kaiser, U. B., Chen, G. L., Manson, J. E., & Goldstein, J. M. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00246 · Cited by 273 · see citing works

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens

Rochon, P. A., Petrović, M., Cherubini, A., Onder, G., O’Mahony, D., Sternberg, S. A., Stall, N. M., & Gurwitz, J. H. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00054-4 · Cited by 198 · see citing works

Advances in the management of chronic insomnia

Kay-Stacey, M., & Attarian, H. P. (2016) · BMJ · doi:10.1136/bmj.i2123 · Cited by 163 · see citing works

Sex differences in sleep, circadian rhythms, and metabolism: Implications for precision medicine

Lok, R., Qian, J., & Chellappa, S. L. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.101926 · Cited by 154 · see citing works

Beyond the binary: Rethinking sex and the brain

Joel, D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.018 · Cited by 140 · see citing works

Sex differences in the brain: a whole body perspective

Vries, G. J. D., & Forger, N. G. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0032-z · Cited by 138 · see citing works

Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature

Farkouh, A., Riedl, T., Gottardi, R., Czejka, M. J., & Kautzky‐Willer, A. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01201-3 · Cited by 132 · see citing works

Assessing whether artificial intelligence is an enabler or an inhibitor of sustainability at indicator level

Gupta, S., Langhans, S. D., Domisch, S., Nerini, F. F., Felländer, A., Battaglini, M., Tegmark, M., & Vinuesa, R. (2021) · Transportation Engineering · doi:10.1016/j.treng.2021.100064 · Cited by 110 · see citing works

Focus on preclinical sex differences will not address women’s and men’s health disparities

Richardson, S. S., Reiches, M. W., Shattuck‐Heidorn, H., LaBonte, M. L., & Consoli, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516958112 · Cited by 102 · see citing works

Sex, hormones, and genotype interact to influence psychiatric disease, treatment, and behavioral research

Gobinath, A. R., Choleris, E., & Galea, L. A. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23872 · Cited by 87 · see citing works

Age and sex in drug development and testing for adults

Tannenbaum, C., & Day, D. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.027 · Cited by 85 · see citing works

The effect of zolpidem on memory consolidation over a night of sleep

Zhang, J., Yetton, B. D., Whitehurst, L. N., Naji, M., & Mednick, S. C. (2020) · SLEEP · doi:10.1093/sleep/zsaa084 · Cited by 82 · see citing works

Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem

Yoon, S., Jeong, S., Jung, E., Kim, K. S., Jeon, I., Lee, Y., Cho, J., Oh, W. Y., & Chung, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-98689-z · Cited by 80 · see citing works

Zolpidem and Gender: Are Women Really At Risk?

Greenblatt, D. J., Harmatz, J. S., & Roth, T. G. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001026 · Cited by 75 · see citing works

Sex and gender in medical education: a national student survey

Jenkins, M., Herrmann, A., Tashjian, A., Ramineni, T., Ramakrishnan, R., Raef, D., Rokas, T., & Shatzer, J. H. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0094-6 · Cited by 76 · see citing works

Mechanistic investigation of the negative food effect of modified release zolpidem

Andreas, C. J., Pepin, X. J. H., Markopoulos, C., Vertzoni, M., Reppas, C. I., & Dressman, J. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.03.011 · Cited by 74 · see citing works

Sex in Context: Limitations of Animal Studies for Addressing Human Sex/Gender Neurobehavioral Health Disparities

Eliot, L., & Richardson, S. S. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1391-16.2016 · Cited by 70 · see citing works

Pharmacological Treatment of Insomnia

Schweitzer, P. K., & Feren, S. D. (2016) · Springer eBooks · doi:10.1007/978-3-319-41400-3_7 · Cited by 68 · see citing works

Sex and gender in health research: updating policy to reflect evidence

Wainer, Z., Carcel, C., Hickey, M., Schiebinger, L. L., Schmiede, A., McKenzie, B. L., Jenkins, C. R., Webster, J. L., Woodward, M., Hehir, A., et al. (2019) · The Medical Journal of Australia · doi:10.5694/mja2.50426 · Cited by 67 · see citing works

Sex and Gender Differences in Migraine—Evaluating Knowledge Gaps

Schroeder, R. A., Brandes, J. L., Buse, D. C., Calhoun, A. H., Eikermann‐Haerter, K., Golden, K., Halker, R. B., Kempner, J., Maleki, N., Moriarty, M., et al. (2018) · Journal of Women s Health · doi:10.1089/jwh.2018.7274 · Cited by 66 · see citing works

Issues related to sex differences in antipsychotic treatment

Crawford, M. B., & DeLisi, L. E. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000243 · Cited by 58 · see citing works

Comprehensive insights into antibiotic residues in livestock products: Distribution, factors, challenges, opportunities, and implications for food safety and public health

Adegbeye, M. J., Adetuyi, B. O., Igirigi, A. I., Adisa, A., Palangı, V., Aiyedun, S., Alvarado-Ramírez, E. R., Elghandour, M. M. M. Y., Molina, O. M., Oladipo, A. A., et al. (2024) · Food Control · doi:10.1016/j.foodcont.2024.110545 · Cited by 62 · see citing works

Considerations and challenges for sex-aware drug repurposing

Fisher, J. L., Jones, E. F., Flanary, V. L., Williams, A. S., Wilk, E. J., & Lasseigne, B. N. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00420-8 · Cited by 47 · see citing works

Evaluation of Sex Differences in Preclinical Pharmacology Research: How Far Is Left to Go?

Allegra, S., Chiara, F., Grazia, D. D., Gaspari, M., & Francia, S. D. (2023) · Pharmaceuticals · doi:10.3390/ph16060786 · Cited by 52 · see citing works

Female psychopharmacology matters! Towards a sex-specific psychopharmacology

Bolea-Alamanac, B. M., Bailey, S., Lovick, T. A., Scheele, D., & Valentino, R. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747578 · Cited by 44 · see citing works

Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test

Laman-Maharg, A., Williams, A. V., Zufelt, M. D., Minie, V. A., Ramos-Maciel, S., Hao, R., Sanchez, E. O., Copeland, T., Silverman, J. L., Leigh, A., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00093 · Cited by 42 · see citing works

Neuroendocrine Control of Sleep

Smith, P. C., & Mong, J. A. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_107 · Cited by 43 · see citing works

Women's Careers in Biomedical Sciences: Implications for the Economy, Scientific Discovery, and Women's Health

Plank-Bazinet, J. L., Heggeness, M. L., Lund, P. K., & Clayton, J. A. (2016) · Journal of Women s Health · doi:10.1089/jwh.2016.6012 · Cited by 40 · see citing works

Zolpidem prescribing practices before and after Food and Drug Administration required product labeling changes

Norman, J. L., Fixen, D. R., Saseen, J. J., Saba, L. M., & Linnebur, S. A. (2017) · SAGE Open Medicine · doi:10.1177/2050312117707687 · Cited by 38 · see citing works

Making a ‘sex-difference fact’: Ambien dosing at the interface of policy, regulation, women’s health, and biology

Zhao, H. H., DiMarco, M., Ichikawa, K., Boulicault, M., Perret, M., Jillson, K., Fair, A., DeJesus, K., & Richardson, S. S. (2023) · Social Studies of Science · doi:10.1177/03063127231168371 · Cited by 40 · see citing works

Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males

Wilson, L. A. B., Zajitschek, S. R. K., Lagisz, M., Mason, J., Haselimashhadi, H., & Nakagawa, S. (2022) · Nature Communications · doi:10.1038/s41467-022-35266-6 · Cited by 31 · see citing works

A systematic review on sex differences in adverse drug reactions related to psychotropic, cardiovascular, and analgesic medications

Shan, Y., Cheung, L., Zhou, Y., Huang, Y., & Huang, R. S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1096366 · Cited by 32 · see citing works

Sex and the Lab: An Alcohol‐Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies

Guizzetti, M., Davies, D. L., Egli, M., Finn, D. A., Molina, P. E., Regunathan, S., Robinson, D. L., & Sohrabji, F. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13072 · Cited by 30 · see citing works

Sexual Differentiation and Sex Differences in Neural Development

Turano, A., Osborne, B. F., & Schwarz, J. M. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_56 · Cited by 29 · see citing works

Gender Differences in the Efficacy and Safety of Chronic Nightly Zolpidem

Roehrs, T., & Roth, T. G. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5574 · Cited by 27 · see citing works

Effectiveness of online learning on health researcher capacity to appropriately integrate sex, gender, or both in grant proposals

Tannenbaum, C., & van Hoof, K. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0197-3 · Cited by 25 · see citing works

Underdetermination in evidence‐based medicine

Chin-Yee, B. H. (2014) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.12258 · Cited by 25 · see citing works

Zolpidem stimulant effect: Induced mania case report and systematic review of cases

Sabé, M., Kashef, H., Gironi, C., & Sentissi, O. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109643 · Cited by 25 · see citing works

Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy

Chan, J. O. Y., Moullet, M., Williamson, B., Arends, R. H., & Reddy, V. P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.874606 · Cited by 24 · see citing works

Sex Proportionality in Pre-clinical and Clinical Trials: An Evaluation of 22 Marketing Authorization Application Dossiers Submitted to the European Medicines Agency

Dekker, M. J. H. J., de Vries, S. T., Versantvoort, C. H. M., Velze, E. G. E. D.-V., Bhatt, M., van Meer, P. J. K., Havinga, I. K., Wied, C. C. G., & Mol, P. G. M. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.643028 · Cited by 21 · see citing works

Why do we need sex‐balanced studies of autism?

Nordahl, C. W. (2023) · Autism Research · doi:10.1002/aur.2971 · Cited by 20 · see citing works

Zolpidem use and motor vehicle collisions in older drivers

Booth, J. N., Behring, M. P., Cantor, R. S., Colantonio, L. D., Davidson, S. L., Donnelly, J. P., Johnson, E., Jordan, K. H., Singleton, C. R., Xie, F., et al. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.12.004 · Cited by 21 · see citing works

Gender Differences in Pharmacokinetics: A Perspective on Contrast Agents

Courchesne, M., Manrique, G., Bernier, L., Moussa, L., Cresson, J., Gutzeit, A., Froehlich, J. M., Koh, D., Chartrand‐Lefebvre, C., & Matoori, S. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00116 · Cited by 20 · see citing works

Sex-Biased Expression of Pharmacogenes across Human Tissues

Idda, M. L., Campesi, I., Fiorito, G., Vecchietti, A., Urru, S. A. M., Solinas, G., Franconi, F., & Floris, M. (2021) · Biomolecules · doi:10.3390/biom11081206 · Cited by 17 · see citing works

Sex as a Biological Variable in Emergency Medicine Research and Clinical Practice: A Brief Narrative Review

McGregor, A. J., Beauchamp, G. A., Wira, C., Perman, S. M., & Safdar, B. (2017) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2017.8.34997 · Cited by 18 · see citing works

Gender Differences and Other Factors Associated with Weight Gain Following Initiation of Infliximab: A Post Hoc Analysis of Clinical Trials

Christian, K. E., Russman, K. M., Rajan, D., Barr, E. A., & Cross, R. K. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz133 · Cited by 17 · see citing works

Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies

Rizzo, S. J. S., McTighe, S. M., & McKinzie, D. L. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_282 · Cited by 16 · see citing works

The relationship between gender and pharmacology

Younes, S. (2024) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2024.100192 · Cited by 15 · see citing works

Pediatric Sleep Pharmacology: A Primer

Troester, M. M., & Pelayo, R. (2015) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2015.03.002 · Cited by 15 · see citing works

Our evolving science: studying the influence of sex in preclinical research

Mazure, C. M. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0068-8 · Cited by 14 · see citing works

Chapter 87 – Pharmacologic Treatment of Insomnia: Benzodiazepine Receptor Agonists

Walsh, J., & Roth, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00087-8 · Cited by 7 · see citing works

Insomnia: A Current Review.

Naha, S., Sivaraman, M., & Sahota, P. K. (2024) · PubMed Central · Cited by 13 · see citing works

Pharmacokinetics of Zolpidem from Sublingual Zolpidem Tartrate Tablets In Healthy Elderly Versus Non-Elderly Subjects

Greenblatt, D. J., Harmatz, J. S., Singh, N., Steinberg, F. J., Roth, T. G., Harris, S., & Kapil, R. P. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0211-3 · Cited by 13 · see citing works

Sublingual and oral zolpidem for insomnia disorder: a 3-month randomized trial

Castro, L. D. S., Otuyama, L. J., dos Santos, C. F., Tufik, S., & Poyares, D. R. (2019) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2019-0389 · Cited by 18 · see citing works

Determining Zolpidem Compliance: Urinary Metabolite Detection and Prevalence in Chronic Pain Patients

Schwope, D. M., DePriest, A. Z., Black, D. L., Caplan, Y. H., Cone, E. J., & Heltsley, R. M. (2014) · Journal of Analytical Toxicology · doi:10.1093/jat/bku068 · Cited by 12 · see citing works

Safety analysis of zolpidem in elderly subjects 80 years of age or older: adverse event monitoring in Japanese subjects

Kajiwara, A., Yamamura, M., Murase, M., Koda, H., Hirota, S., Ishizuka, T., Morita, K., Oniki, K., Saruwatari, J., & Nakagawa, K. (2015) · Aging & Mental Health · doi:10.1080/13607863.2015.1031640 · Cited by 12 · see citing works

The Influence of Body Image, Insight, and Mental Health Confidence on Medication Adherence in Young Adult Women with Mental Disorders

Lee, E.-M., & Jang, M. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18083866 · Cited by 12 · see citing works

Sex bias and omission exists in Batten disease research: Systematic review of the use of animal disease models

McShane, A., & Mole, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166489 · Cited by 11 · see citing works

Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats

Peer, C. J., Strope, J. D., Beedie, S., Ley, A. M., Holly, A. J., Calis, K. A., Farkas, R. H., Parepally, J. M. R., Men, A. Y., Fadiran, E. O., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00260 · Cited by 10 · see citing works

Clinical Pharmacokinetics and Pharmacodynamics of Anxiolytics and Sedative/Hypnotics

DeVane, C. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-27883-4_10 · Cited by 9 · see citing works

Training emergency physicians in sex- and gender-based medicine: assessing attitudes of program directors and residency graduates

Madsen, T. E., & McGregor, A. J. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0098-2 · Cited by 8 · see citing works

Joining the Effort: The Challenges in Establishing Guidelines for Sex- and Gender-specific Research Design in Clinical Therapeutic Studies

McGregor, A. J., Markowitz, J. S., Forrester, J. E., & Shader, R. I. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.09.005 · Cited by 8 · see citing works

Exploring Differences in Pharmacometrics of Rabeprazole between Genders via Population Pharmacokinetic–Pharmacodynamic Modeling

Jeong, S., Jang, J.-H., & Lee, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11113021 · Cited by 7 · see citing works

Sleep Medications and Women: a Review of Issues to Consider for Optimizing the Care of Women with Sleep Disorders

Krystal, A. D., & Attarian, H. P. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0060-1 · Cited by 7 · see citing works

Gender Medicine and Pharmacology

Allegra, S., Chiara, F., & Francia, S. D. (2024) · Biomedicines · doi:10.3390/biomedicines12020265 · Cited by 6 · see citing works

Pharmacokinetics of a Novel Zolpidem Nasal Spray for Rapid Management of Insomnia: First Trial in Humans

Li, C.-T., Su, T., Wang, Y., Lee, B., Toh, M., & Ho, T. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6264 · Cited by 6 · see citing works

Sex-related differences in disposition of sulfamethoxazole, N-acetyl-sulfamethoxazole and trimethoprim in yellow catfish (Pelteobagrus fulvidraco) following a single oral administration

Liu, Y., Han, G., Dong, J., Yang, Y., Yang, Q., Xu, N., Zhou, S., & Ai, X. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735869 · Cited by 6 · see citing works

Sleep Pharmacogenetics: The Promise of Precision Medicine.

Krystal, A., & Prather, A. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.05.003 · Cited by 6 · see citing works

Overview of approved psychiatric medications 2008-2023: A systematic review

IsHak, W. W., Totlani, J., Murphy, N., Renteria, S., Chang, T. Y., Abdelsalam, R., Salem, M., Meyer, A., Khan, R., Chandy, T., et al. (2024) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2024.21.3.0705 · Cited by 5 · see citing works

Spezielle Aspekte der pharmakotherapeutischen Behandlung forensisch untergebrachter Patientinnen

Singer, M., & Eckermann, G. (2023) · Forensische Psychiatrie Psychologie Kriminologie · doi:10.1007/s11757-023-00762-y · Cited by 5 · see citing works

Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high‐performance liquid chromatography coupled to tandem mass spectrometry

Mendes, G. D., Pereira, T. D. S., Rodrigues, J., Santos, E. M., Souza, M. R., Lopes‐Martins, R. Á. B., Antunes, N. D. J., Moreno, R. A., & Nucci, G. D. (2019) · Biomedical Chromatography · doi:10.1002/bmc.4731 · Cited by 5 · see citing works

“My Body Changed a Lot After Taking Medication. I'm Trying to Hide It but…” A Qualitative Exploration of Body Image Experiences of Women Living With Schizophrenia

İnan, F. Ş., Tuncer, G. Z., & Duman, Z. Ç. (2024) · International Journal of Mental Health Nursing · doi:10.1111/inm.13475 · Cited by 4 · see citing works

Systemic Review of AI Reshaped Blockchain Applications

Shamsuddoha, M., Kashem, M. A., & Koul, S. (2023) · Communications in computer and information science · doi:10.1007/978-3-031-28180-8_32 · Cited by 4 · see citing works

Pharmacotherapy: Sex and gender evidence in medication safety and efficacy

Sleeper, R. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816569-0.00012-7 · Cited by 3 · see citing works

In Silico Personalized Study for Zolpidem Based on Sex Difference

Saldanha, L., Costa, B., & Vale, N. (2022) · Future Pharmacology · doi:10.3390/futurepharmacol2020008 · Cited by 3 · see citing works

Gendermedizin: Patientinnen unterscheiden sich von Patienten

Steck, N., Lisa, M., Candinas, D., Beck‐Schimmer, B., & Gebhard, C. (2020) · Bulletin des Médecins Suisses · doi:10.4414/bms.2020.18527 · Cited by 3 · see citing works

Improving the Health of Women Across the Life Span: Recognizing Biological Barriers and Beyond

Evans, M. L., & McGregor, A. J. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.02.004 · Cited by 3 · see citing works

Artificial intelligence in cancer diagnosis and therapy using sex and gender as precision biomarkers

Karnwal, A., Rehman, A.-U., Jassim, A. Y., Kumar, G., Al-Tawaha, A. R., & Nesterova, N. (2026) · Discover Oncology · doi:10.1007/s12672-026-05256-x · Cited by 2 · see citing works

Exposure assessment of laboratory workers to hazardous waste from mice treated with tamoxifen and bromodeoxyuridine

Wayne, N. L., Duarte‐Vogel, S., Kraemer, S., & Rager, J. D. (2018) · ACS Chemical Health & Safety · doi:10.1016/j.jchas.2018.08.003 · Cited by 2 · see citing works

Menopause and sleep disturbances

Stenyaeva, N. N., Khritinin, D. F., & Steniaev, E. Y. (2023) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2023-333 · Cited by 2 · see citing works

Clinically Significant Interactions with Benzodiazepines

Valdes, J., Boggs, D. L., Boggs, A. A., & Rey, J. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-27883-4_19 · Cited by 2 · see citing works

Estradiol Action at the Median Preoptic Nucleus is Necessary and Sufficient for Sleep Suppression in Female RatsPreprint

Smith, P. C., Cusmano, D. M., Viechweg, S. S., Schwartz, M. D., & Mong, J. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.29.223669 · Cited by 2 · see citing works

Advancing Health Equity in Europe: Explore, Tailor, Implement, and Evaluate ( ETIE )—A Framework of Diversity and Fairness in Pharmacoepidemiologic Research

Vallejo‐Yagüe, E., de Vries, S. T., Parra‐Casado, D. L., Gardarsdóttir, H., Faquetti, M. L., van Valkengoed, I. G. M., Aubrun, E., Douros, A., Guedes, S., la Torre, A. M.-D., et al. (2025) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.70175 · Cited by 1 · see citing works

Market Failures in Women’s Health: Systemic Undervaluation and Paths to Reform

Thendral, A. (2025) · American journal of student research. · doi:10.70251/hyjr2348.34118139 · Cited by 1 · see citing works

Residual Effects of Acute and Subchronic Zolpidem Treatments on Attentional Processes in Aged Female Rats

Léger, M., Boulouard, M., Liet, C., Grayson, B., Harte, M., Neill, J. C., Bocca, M., & Lelong‐Boulouard, V. (2025) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.70067 · Cited by 1 · see citing works

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

Hunter, M., Coig, R., Risler, L. J., Patton, K. K., Narla, R. R., Greene, D. N., Burke, A. K., Micks, E., Hébert, M. F., & Cirrincione, L. R. (2025) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.70093 · Cited by 1 · see citing works

Analysis of the associations of sex, age, and prescription medications with suicide-related adverse events and drug-related depression by using the Japanese Adverse Drug Event Report database

Kageyama, K., Sato, M., Ito, S., Ino, Y., Nakao, S., Bunchuailua, W., Rungpragayphan, S., Krichanchai, S., Iguchi, K., Ishiguro, M., et al. (2026) · Psychiatry Research Communications · doi:10.1016/j.psycom.2026.100250 · Cited by 1 · see citing works

Prediction of herb–drug interaction between hyperforin and sedative hypnotics (zolpidem, alprazolam, and midazolam) using physiologically-based pharmacokinetic modeling

Shin, A., Jang, B., Cho, S., Kim, Y. S., Park, M. S., Park, K.-I., Kim, Y. W., & Kim, C. O. (2024) · Molecular & Cellular Toxicology · doi:10.1007/s13273-024-00427-9 · Cited by 1 · see citing works

Psychotropic Drug Use and Associated Factors Among Acutely Admitted Older People: A Cross-Sectional Study of a Clinical Sample

Gasi, E., Gustafsson, M. V., & Kindstedt, J. (2024) · Drugs - Real World Outcomes · doi:10.1007/s40801-024-00455-w · Cited by 1 · see citing works

Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression

Wright, B. T. (2016) · doi:10.21007/etd.cghs.2016.0408 · Cited by 1 · see citing works

Implications for Human Health and Development

Geary, D. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801562-9.00008-9

Gendermedizin: Patientinnen unterscheiden sich von Patienten

Steck, N., Lisa, M., Candinas, D., Beck‐Schimmer, B., & Gebhard, C. (2020) · Bulletin des Médecins Suisses · doi:10.4414/saez.2020.18527

Sex bias in surgical research

Rouan, J. R., & Kibbe, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822959-0.00039-0

Considerations and Challenges for Sex-Aware Drug RepurposingPreprint

Fisher, J., Jones, E., Flanary, V. L., Williams, A. S., Ramsey, E., & Lasseigne, B. N. (2021) · Preprints.org · doi:10.20944/preprints202112.0380.v1

Considerations and Challenges for Sex-Aware Drug RepurposingPreprint

Fisher, J., Jones, E., Flanary, V. L., Williams, A. A., Ramsey, E., & Lasseigne, B. N. (2022) · Preprints.org · doi:10.20944/preprints202112.0380.v2

Sex differences in allometry for mouse phenotypic traits indicate that females are not scaled malesPreprint

Wilson, L. A. B., Zajitschek, S. R. K., Lagisz, M., Mason, J., Haselimashhadi, H., & Nakagawa, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.29.486193

Hypersomnia due to a medication or substance

Schweitzer, P. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00103-1

References

(2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801562-9.09998-1

Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults

Greenblatt, D. J., Harmatz, J. S., Roth, T. G., Singh, N., Moline, M. L., Harris, S., & Kapil, R. P. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.03.007 · Cited by 43 · see citing works

Pharmacokinetics of Zolpidem from Sublingual Zolpidem Tartrate Tablets In Healthy Elderly Versus Non-Elderly Subjects

Greenblatt, D. J., Harmatz, J. S., Singh, N., Steinberg, F. J., Roth, T. G., Harris, S., & Kapil, R. P. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0211-3 · Cited by 13 · see citing works

Einfluss des Alterns auf die Pharmakokinetik von Zolpidem bei Frauen und Männern

Jurksas, P. (2006)

Comparative pharmacokinetics of zolpidem tartrate in five ethnic populations of China

Guo, T., Mao, G., Zhao, L., Xia, D., & Yang, L. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2014.02.001 · Cited by 9 · see citing works

Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation of Sex-Dependent Differences

Greenblatt, D. J., Harmatz, J. S., Moltke, L. L., Wright, C. E., Durol, A. L. B., Harrel-Joseph, L. M., & Shader, R. I. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39253-5 · Cited by 123 · see citing works