Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs
Abstract
Combining two or more antiretroviral drugs in one medical product is an interesting but challenging strategy for developing topical anti-HIV microbicides. We developed a new vaginal delivery system comprising the incorporation of nanoparticles (NPs) into a polymeric film base - NPs-in-film - and tested its ability to deliver tenofovir (TFV) and efavirenz (EFV). EFV-loaded poly(lactic-co-glycolic acid) NPs were incorporated alongside free TFV into fast dissolving films during film manufacturing. The delivery system was characterized for physicochemical properties, as well as genital distribution, local and systemic 24h pharmacokinetics (PK), and safety upon intravaginal administration to mice. NPs-in-film presented suitable technological, mechanical and cytotoxicity features for vaginal use. Retention of NPs in vivo was enhanced both in vaginal lavages and tissue when associated to film. PK data evidenced that vaginal drug levels rapidly decreased after administration but NPs-in-film were still able to enhance drug concentrations of EFV. Obtained values for area-under-the-curve for EFV were around one log10 higher than those for the free drugs in aqueous vehicle (phosphate buffered saline). Film alone also contributed to higher and more prolonged local drug levels as compared to the administration of TFV and EFV in aqueous vehicle. Systemic exposure to both drugs was low. NPs-in-film was found to be safe upon once daily vaginal administration to mice, with no significant genital histological changes or major alterations in cytokine/chemokine profiles being observed. Overall, the proposed NPs-in-film system seems to be an interesting delivery platform for developing combination vaginal anti-HIV microbicides.
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The improved tissue concentrations from film-embedded nanoparticles were observed only within the first hour of administration, and not at later times.
“However, the improved tissue concentrations were observed only within the first hour of administration, and not at later times.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [25]
Cunha-Reis et al. demonstrated that nanoparticles loaded with efavirenz and embedded in a water-soluble film showed lower leakage and enabled higher tissue concentrations than nanoparticle dispersions.
“Cunha-Reis et al. demonstrated that nanoparticles loaded with an anti-HIV drug (efavirenz) and embedded in a water-soluble film showed lower leakage and enabled higher tissue concentrations than nanoparticle dispersions 25 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [25]
Cites
Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., et al. (2010) · Science · doi:10.1126/science.1193748 · Cited by 2,435 · see citing works
Tenofovir-based preexposure prophylaxis for HIV infection among African women.
Marrazzo, J. M., Ramjee, G., Richardson, B. A., Gomez, K., Mgodi, N., Nair, G., Palanee, T., Nakabiito, C., van der Straten, A., Noguchi, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402269 · Cited by 1,296 · see citing works
Use of a vaginal ring containing dapivirine for HIV-1 prevention in women.
Baeten, J. M., Palanee-Phillips, T., Brown, E. R., Schwartz, K., Soto-Torres, L. E., Govender, V., Mgodi, N. M., Matovu Kiweewa, F., Nair, G., Mhlanga, F., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506110 · Cited by 772 · see citing works
Owen, D. H., & Katz, D. F. (1999) · Contraception · doi:10.1016/s0010-7824(99)00010-4 · Cited by 721 · see citing works
Hillier, S. L., Moench, T. R., Shattock, R. J., Black, R. J., Reichelderfer, P. S., & Veronese, F. D. M. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000159671.25950.74 · Cited by 572 · see citing works
Sosnik, A., das Neves, J., & Sarmento, B. F. C. C. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.010 · Cited by 489 · see citing works
Self-citationWoodrow, K. A., Cu, Y., Booth, C. J., Saucier-Sawyer, J. K., Wood, M. J., & Saltzman, W. M. (2009) · Nature Materials · doi:10.1038/nmat2444 · Cited by 437 · see citing works
Kim, D., & Martin, D. C. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.12.021 · Cited by 432 · see citing works
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
Baeten, J. M., Palanee‐Phillips, T., Brown, E. R., Schwartz, K. D., Soto-Torres, L. E., Govender, V., Mgodi, N. M., Kiweewa, F. M., Nair, G., Mhlanga, F., et al. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000489577.60775.40 · Cited by 373 · see citing works
Defeating AIDS—advancing global health
Piot, P., Abdool Karim, S. S., Hecht, R., Legido-Quigley, H., Buse, K., Stover, J., Resch, S., Ryckman, T., Møgedal, S., Dybul, M., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60658-4 · Cited by 293 · see citing works
Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
Anderson, P. L., Kiser, J. J., Gardner, E. M., Rower, J. E., Meditz, A. L., & Grant, R. M. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq447 · Cited by 194 · see citing works
In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide
Rohan, L. C., Moncla, B. J., Ayudhya, R. P. K. N., Cost, M. R., Huang, Y., Gai, F., Billitto, N., Lynam, J. D., Pryke, K. M., Graebing, P. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009310 · Cited by 183 · see citing works
Liu, D., Bimbo, L. M., Mäkilä, E. M., Villanova, F., Kaasalainen, M. H., Herranz‐Blanco, B., Caramella, C. M., Lehto, V., Salonen, J., Herzig, K., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.05.036 · Cited by 156 · see citing works
Drug delivery strategies for poorly water-soluble drugs: the industrial perspective
van Hoogevest, P., Liu, X.-L., & Fahr, A. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.614228 · Cited by 144 · see citing works
Polymer-based nanocarriers for vaginal drug delivery
das Neves, J., Nunes, R., Machado, A., & Sarmento, B. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.004 · Cited by 138 · see citing works
Self-citationDenton, P. W., Othieno, F. A., Martinez-Torres, F. J., Zou, W., Krisko, J. F., Fleming, E. H., Zein, S., Powell, D. A., Wahl, A. R., Kwak, Y. T., et al. (2011) · Journal of Virology · doi:10.1128/jvi.00537-11 · Cited by 138 · see citing works
Vaginal microbicides: detecting toxicities in vivothat paradoxically increase pathogen transmission
Cone, R. A., Hoen, T. E., Wong, X., Abusuwwa, R., Anderson, D. J., & Moench, T. R. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-90 · Cited by 135 · see citing works
In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
Cu, Y., Booth, C. J., & Saltzman, W. M. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.036 · Cited by 129 · see citing works
Microbicides: Topical Prevention against HIVPreprint
Shattock, R. J., & Rosenberg, Z. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007385 · Cited by 116 · see citing works
Dezzutti, C. S., Brown, E. R., Moncla, B. J., Russo, J., Cost, M. R., Wang, L., Uranker, K., Ayudhya, R. P. K. N., Pryke, K. M., Pickett, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048328 · Cited by 113 · see citing works
Seremeta, K. P., Chiappetta, D. A., & Sosnik, A. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.06.038 · Cited by 109 · see citing works
Microbicide vaginal rings: Technological challenges and clinical development
Malcolm, K. R., Boyd, P. J., McCoy, C. F., & Murphy, D. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.015 · Cited by 102 · see citing works
Schwartz, J. L., Rountree, W., Kashuba, A. D. M., Brache, V., Creinin, M. D., Poindexter, A. N., & Kearney, B. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025974 · Cited by 97 · see citing works
Date, A. A., Shibata, A., Goede, M., Sanford, B. L., Bruzzo, K. L., Belshan, M., & Destache, C. J. (2012) · Antiviral Research · doi:10.1016/j.antiviral.2012.09.015 · Cited by 91 · see citing works
Moreno, J., Vargas, M. A., Madiedo, J. M., Muñoz, J., Rivas, J., & Guerrero, M. G. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000205)67:3 · Cited by 90 · see citing works
Freeling, J. P., Koehn, J., Shu, C., Sun, J., & Ho, R. J. Y. (2015) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0210 · Cited by 85 · see citing works
Kyongo, J. K., Jespers, V., Goovaerts, O., Míchiels, J., Menten, J., Fichorova, R. N., Crucitti, T., Vanham, G., & Ariën, K. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043951 · Cited by 83 · see citing works
das Neves, J., Amaral, M. H., & Bahia, M. F. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.12.007 · Cited by 81 · see citing works
das Neves, J., & Sarmento, B. F. C. C. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.02.007 · Cited by 77 · see citing works
Self-citationKovarova, M., Council, O. D., Date, A. A., Long, J. M., Nochii, T., Belshan, M., Shibata, A., Vincent, H., Baker, C. E., Thayer, W. O., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005075 · Cited by 77 · see citing works
Interactions of Microbicide Nanoparticles with a Simulated Vaginal Fluid
das Neves, J., Rocha, C. M. R., Gonçalves, M. P., Carrier, R. L., Amiji, M. M., Bahia, M. F., & Sarmento, B. F. C. C. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300408m · Cited by 76 · see citing works
Self-citationThe Development of Vaginal Microbicides for the Prevention of HIV Transmission
Weber, J. N., Desai, K., Darbyshire, J. H., & on behalf of the Microbicides Development Programme (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020142 · Cited by 75 · see citing works
Kashuba, A. D. M., Gengiah, T. N., Werner, L., Yang, K., White, N., Karim, Q. A., & Karim, S. S. A. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000607 · Cited by 73 · see citing works
das Neves, J., Araújo, F., Andrade, F., Amiji, M. M., Bahia, M. F., & Sarmento, B. F. C. C. (2014) · Pharmaceutical Research · doi:10.1007/s11095-013-1287-x · Cited by 72 · see citing works
Self-citationBiodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells
Gu, J., Yang, S., & Ho, E. A. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00073 · Cited by 71 · see citing works
Machado, A., Cunha-Reis, C., Araújo, F., Nunes, R., Seabra, V., Ferreira, D., das Neves, J., & Sarmento, B. F. C. C. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.08.018 · Cited by 70 · see citing works
Self-citationWoodsong, C., & Holt, J. D. S. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.02.004 · Cited by 68 · see citing works
Gali, Y., Delézay, O., Brouwers, J., Addad, N., Augustijns, P., Bourlet, T., Hamzeh‐Cognasse, H., Ariën, K. K., Pozzetto, B., & Vanham, G. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00456-10 · Cited by 66 · see citing works
Bunge, K. E., Dezzutti, C. S., Rohan, L. C., Hendrix, C. W., Marzinke, M. A., Richardson‐Harman, N., Moncla, B. J., Devlin, B., Meyn, L. A., Spiegel, H. M. L., et al. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000897 · Cited by 66 · see citing works
Baeten, J. M., & Celum, C. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-050911-163701 · Cited by 64 · see citing works
Drug Synergy of Tenofovir and Nanoparticle-Based Antiretrovirals for HIV Prophylaxis
Chaowanachan, T., Krogstad, E. A., Ball, C. S., & Woodrow, K. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061416 · Cited by 63 · see citing works
Keller, M. J., Mesquita, P. M. M., Torres, N. M., Cho, S., Shust, G. F., Madan, R. P., Cohen, H. W., Petrie, J., Ford, T., Soto-Torres, L. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008781 · Cited by 63 · see citing works
Nanomedicine in the development of anti-HIV microbicides
das Neves, J., Nunes, R., Rodrigues, F., & Sarmento, B. F. C. C. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.017 · Cited by 59 · see citing works
Self-citationA Potent Combination Microbicide that Targets SHIV-RT, HSV-2 and HPV
Kizima, L., Rodríguez, A., Kenney, J., Derby, N. R., Mizenina, O. A., Menon, R., Seidor, S., Zhang, S., Levendosky, K., Jean‐Pierre, N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094547 · Cited by 55 · see citing works
Zhou, T., Hu, M., Cost, M. R., Poloyac, S. M., & Rohan, L. C. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0032 · Cited by 52 · see citing works
Meng, J., Zhang, T., Agrahari, V., Ezoulin, M. J. M., & Youan, B.-B. C. (2014) · Nanomedicine · doi:10.2217/nnm.13.136 · Cited by 51 · see citing works
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles
Tosi, G., Rivasi, F., Gandolfi, F., Costantino, L., Vandelli, M. A., & Forni, F. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.025 · Cited by 47 · see citing works
Formulation Development of Retrocyclin 1 Analog RC-101 as an Anti-HIV Vaginal Microbicide Product
Sassi, A. B., Cost, M. R., Cole, A. L., Cole, A. M., Patton, D. L., Gupta, P., & Rohan, L. C. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01190-10 · Cited by 47 · see citing works
Zhang, W., Hu, M., Shi, Y., Gong, T., Dezzutti, C. S., Moncla, B. J., Sarafianos, S. G., Parniak, M. A., & Rohan, L. C. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1678-2 · Cited by 45 · see citing works
Murphy, D. J., Desjardins, D., Dereuddre‐Bosquet, N., Brochard, P., Perrot, L., Pruvost, A., Grand, R. L., Lagatie, O., Vanhooren, L., Feyaerts, M., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku160 · Cited by 44 · see citing works
Wilson, S. S., Cheshenko, N., Fakioglu, E., Mesquita, P. M. M., Keller, M. J., & Herold, B. C. (2009) · Antiviral Therapy · doi:10.3851/imp1463 · Cited by 42 · see citing works
Vaginal deployment and tenofovir delivery by microbicide gels
Gao, Y., Yuan, A., Chuchuen, O., Ham, A. S., Yang, K., & Katz, D. F. (2015) · Drug Delivery and Translational Research · doi:10.1007/s13346-015-0227-1 · Cited by 41 · see citing works
Clark, M. R., Peet, M., Davis, S., Doncel, G. F., & Friend, D. R. (2014) · Pharmaceutics · doi:10.3390/pharmaceutics6040616 · Cited by 40 · see citing works
Zhang, W., Parniak, M. A., Sarafianos, S. G., Cost, M. R., & Rohan, L. C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.056 · Cited by 39 · see citing works
Preclinical assessments of vaginal microbicide candidate safety and efficacy
Fernández-Romero, J. A., Teleshova, N., Zydowsky, T. M., & Robbiani, M. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.005 · Cited by 38 · see citing works
Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4+ immune cells
Ho, E. A., Chen, Y. A., Dash, Sayre, C. L., Davies, N. M., Gu, & Yang, S. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s46958 · Cited by 38 · see citing works
Increased Dapivirine Tissue Accumulation through Vaginal Film Codelivery of Dapivirine and Tenofovir
Akil, A., Devlin, B., Cost, M. R., & Rohan, L. C. (2014) · Molecular Pharmaceutics · doi:10.1021/mp4007024 · Cited by 37 · see citing works
A novel vaginal drug delivery system: anti-HIV bioadhesive film containing abacavir
Ghosal, K., Ranjan, A., & Bhowmik, B. B. (2014) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-014-5204-6 · Cited by 36 · see citing works
Grammen, C., Augustijns, P., & Brouwers, J. (2012) · Antiviral Research · doi:10.1016/j.antiviral.2012.09.011 · Cited by 36 · see citing works
Veselinović, M., Yang, K.-H., LeCureux, J., Sykes, C., Remling‐Mulder, L., Kashuba, A. D. M., & Akkina, R. (2014) · Virology · doi:10.1016/j.virol.2014.07.008 · Cited by 35 · see citing works
Effects of menstrual cycle on gene transfection through mouse vagina for DNA vaccine
Kanazawa, T., Takashima, Y., Hirayama, S., & Okada, H. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.04.038 · Cited by 35 · see citing works
Pereira, L. E., Clark, M. R., Friend, D. R., Garber, D. A., McNicholl, J. M., Hendry, R. M., Doncel, G. F., & Smith, J. M. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02336-13 · Cited by 31 · see citing works
Segarra, T. J., Fakioglu, E., Cheshenko, N., Wilson, S. S., Mesquita, P. M. M., Doncel, G. F., & Herold, B. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027675 · Cited by 30 · see citing works
Srinivasan, P., Zhang, J., Martin, A. M., Kelley, K., McNicholl, J. M., Buckheit, R. W., Smith, J. M., & Ham, A. S. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00082-16 · Cited by 30 · see citing works
Ham, A. S., Ugaonkar, S. R., Shi, L., Buckheit, K. W., Lakougna, H., Nagaraja, U., Gwozdz, G., Goldman, L., Kiser, P. F., & Buckheit, R. W. (2012) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23026 · Cited by 28 · see citing works
Moss, J. A., Butkyavichene, I., Churchman, S. A., Gunawardana, M., Fanter, R. K., Miller, C. S., Yang, F., Easley, J. T., Marzinke, M. A., Hendrix, C. W., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00391-16 · Cited by 27 · see citing works
Cost, M. R., Dezzutti, C. S., Clark, M. R., Friend, D. R., Akil, A., & Rohan, L. C. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06284-11 · Cited by 24 · see citing works
New Candidate Biomarkers in the Female Genital Tract to Evaluate Microbicide Toxicity
Fields, S., Song, B., Rasoul, B. A., Fong, J. M., Works, M. G., Shew, K., Yiu, Y. Y., Mirsalis, J. C., & D’Andrea, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110980 · Cited by 24 · see citing works
das Neves, J., Martins, J. P., & Sarmento, B. F. C. C. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.015 · Cited by 24 · see citing works
Self-citationRohan, L. C., Devlin, B., & Yang, H. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2013_357 · Cited by 23 · see citing works
Topical microbicides and HIV prevention in the female genital tract.
Cottrell, M. L., & Kashuba, A. D. M. (2014) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.292 · Cited by 22 · see citing works
Impact of Sex on the Pharmacokinetics and Pharmacodynamics of 1% Tenofovir Gel
Herold, B. C., Chen, B. A., Salata, R. A., Marzinke, M. A., Kelly, C. W., Dezzutti, C. S., McGowan, I., Galaska, B., Levy, L., Piper, J. M., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ913 · Cited by 21 · see citing works
Zhou, T., Hu, M., Pearlman, A., & Rohan, L. C. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.07.009 · Cited by 19 · see citing works
Hsu, C. C. S., Park, J. Y., Ho, N. F. H., Higuchi, W. I., & Fox, J. L. (1983) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600720620 · Cited by 17 · see citing works
UV Cross-Linked Redox-Responsive Hydrogels for Co-Delivery of Hydrophilic and Hydrophobic Drugs
Ma, D., Zhou, X., Yang, Y.-F., You, Y., Liu, Z., Lin, J., Liu, T., & Xue, W. (2013) · Science of Advanced Materials · doi:10.1166/sam.2013.1587 · Cited by 12 · see citing works
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1 of the 76 references couldn’t be matched to a known paper.
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Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Recent developments in functionalized polymer nanoparticles for efficient drug delivery system
Sur, S., Rathore, A., Dave, V., Reddy, K. R., Chouhan, R. S., & Sadhu, V. B. (2019) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2019.100397 · Cited by 517 · see citing works
Recent Advances in Polymer-Based Vaginal Drug Delivery Systems
Osmałek, T. Z., Froelich, A., Jadach, B., Tatarek, A., Gadziński, P., Falana, A., Gralińska, K., Ekert, M., Puri, V., Wrotyńska-Barczyńska, J., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060884 · Cited by 145 · see citing works
Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art
Leyva‐Gómez, G., Piñón‐Segundo, E., Mendoza‐Muñoz, N., Zambrano‐Zaragoza, M. L., Mendoza-Elvira, S. E., & Quintanar‐Guerrero, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061549 · Cited by 117 · see citing works
Yang, H., Li, J., Patel, S. K., Palmer, K. E., Devlin, B., & Rohan, L. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11040184 · Cited by 100 · see citing works
Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy
Martins, C., Araújo, F., Gomes, M. J., Fernandes, C., Nunes, R., Li, W., Santos, H. A., Borges, F., & Sarmento, B. F. C. C. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.01.014 · Cited by 85 · see citing works
Self-citationPromising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update
Pandey, M., Choudhury, H., Aziz, A. A., Bhattamisra, S. K., Gorain, B., Carine, T., Toong, T. W., Yi, N. J., & Yi, L. W. (2020) · Polymers · doi:10.3390/polym13010026 · Cited by 87 · see citing works
Taghe, S., Mirzaeei, S., Alany, R. G., & Nokhodchi, A. (2020) · Biomedicines · doi:10.3390/biomedicines8110466 · Cited by 68 · see citing works
Rossi, S., Vigani, B., Sandri, G., Bonferoni, M. C., Caramella, C. M., & Ferrari, F. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1645117 · Cited by 68 · see citing works
Antibodies and associates: Partners in targeted drug delivery
Kennedy, P. J., Oliveíra, C., Granja, P. L., & Sarmento, B. F. C. C. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.004 · Cited by 68 · see citing works
Self-citationCurrent and Future PrEP Medications and Modalities: On-demand, Injectables, and Topicals
Beymer, M. R., Holloway, I. W., Pulsipher, C., & Landovitz, R. J. (2019) · Current HIV/AIDS Reports · doi:10.1007/s11904-019-00450-9 · Cited by 67 · see citing works
Notario-Pérez, F., Ruíz, R., & Veiga, M.-D. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s133170 · Cited by 64 · see citing works
Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art
Notario-Pérez, F., Cazorla-Luna, R., Martín-Illana, A., Galante, J., Ruíz, R., das Neves, J., & Veiga, M.-D. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.032 · Cited by 62 · see citing works
Delivery technologies for women’s health applications
Swingle, K. L., Ricciardi, A. S., Peranteau, W. H., & Mitchell, M. J. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00040-w · Cited by 64 · see citing works
Composite films for vaginal delivery of tenofovir disoproxil fumarate and emtricitabine
Cautela, M. P., Halamish, H. M., Sosnik, A., Sarmento, B. F. C. C., & das Neves, J. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.02.001 · Cited by 57 · see citing works
Self-citationZhang, G., Campbell, G. R., Zhang, Q., Maule, E., Hanna, J., Gao, W., Zhang, L., & Spector, S. A. (2020) · mBio · doi:10.1128/mbio.00903-20 · Cited by 48 · see citing works
Carvalho, G. C., Araújo, V. H. S., Fonseca‐Santos, B., de Araújo, J. T. C., de Souza, M. P. C., Duarte, J. L., & Chorilli, M. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120635 · Cited by 47 · see citing works
Vanić, Ž., Jøraholmen, M. W., & Škalko‐Basnet, N. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113855 · Cited by 46 · see citing works
Emerging Trends and Potential Prospects in Vaginal Drug Delivery
Mahant, S., Sharma, A. K., Gandhi, H., Wadhwa, R., Dua, K., & Kapoor, D. N. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220413131243 · Cited by 45 · see citing works
Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules
Castro, P. M., Sousa, F., Magalhães, R. M., Ruiz‐Henestrosa, V. M. P., Pilosof, A. M. R., Madureira, A. R., Sarmento, B. F. C. C., & Pintado, M. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.04.032 · Cited by 44 · see citing works
Self-citationLou, S., Zhao, Z., Dezort, M., Lohneis, T., & Zhang, C. (2018) · ACS Omega · doi:10.1021/acsomega.8b00949 · Cited by 43 · see citing works
Sustained-release Griffithsin nanoparticle-fiber composites against HIV-1 and HSV-2 infections
Tyo, K. M., Lasnik, A. B., Zhang, L., Mahmoud, M. Y., Jenson, A. B., Fuqua, J. L., Palmer, K. E., & Steinbach-Rankins, J. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.006 · Cited by 43 · see citing works
Recent Advances in the Excipients Used in Modified Release Vaginal Formulations
Dedeloudi, A., Siamidi, A., Pavlou, P., & Vlachou, M. (2022) · Materials · doi:10.3390/ma15010327 · Cited by 42 · see citing works
The Potential of Nanotechnology in Medically Assisted Reproduction
Remião, M. H., Segatto, N. V., Pohlmann, A. R., Guterres, S. S., Seixas, F. K., & Collares, T. V. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00994 · Cited by 42 · see citing works
Women-specific routes of administration for drugs: A critical overview
das Neves, J., Notario-Pérez, F., & Sarmento, B. F. C. C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113865 · Cited by 41 · see citing works
Self-citationRecent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials
Chindamo, G., Sapino, S., Peira, E., Chirio, D., & Gallarate, M. (2021) · Nanomaterials · doi:10.3390/nano11020311 · Cited by 41 · see citing works
Irvin-Choy, N. S., Nelson, K. M., Dang, M. N., Gleghorn, J. P., & Day, E. S. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102412 · Cited by 37 · see citing works
Nunes, R., Araújo, F., Tavares, J., Sarmento, B. F. C. C., & das Neves, J. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.06.029 · Cited by 36 · see citing works
Self-citationPharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems
Mesquita, L., Galante, J., Nunes, R., Sarmento, B. F. C. C., & das Neves, J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030145 · Cited by 36 · see citing works
Self-citationAriza-Sáenz, M., Espina, M., Bolaños, N., Calpena, A. C., Gomara, M. J., Haro, I., & García, M. L. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.08.008 · Cited by 35 · see citing works
Nunes, R., Araújo, F., Barreiros, L., Bártolo, I., Segundo, M. A., Taveira, N., Sarmento, B. F. C. C., & das Neves, J. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b12214 · Cited by 35 · see citing works
Self-citationTopical Inserts: A Versatile Delivery Form for HIV Prevention
Peet, M. M., Agrahari, V., Anderson, S. M., Hanif, H., Singh, O., Thurman, A. R., Doncel, G. F., & Clark, M. R. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11080374 · Cited by 35 · see citing works
Design of nanomaterials for applications in maternal/fetal medicine
Irvin-Choy, N. S., Nelson, K. M., Gleghorn, J. P., & Day, E. S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00612b · Cited by 35 · see citing works
PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen
Lozoya-Agulló, I., Araújo, F., González‐Álvarez, I., Merino‐Sanjuán, M., González‐Álvarez, M., Bermejo, M., & Sarmento, B. F. C. C. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.12.009 · Cited by 33 · see citing works
Self-citationLyophilized Drug-Loaded Solid Lipid Nanoparticles Formulated with Beeswax and Theobroma Oil
Amekyeh, H., & Billa, N. (2021) · Molecules · doi:10.3390/molecules26040908 · Cited by 32 · see citing works
Nunes, R., Bogas, S., Faria, M. J., Gonçalves, H., Lúcio, M., Viseu, T. M. R., Sarmento, B. F. C. C., & das Neves, J. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.003 · Cited by 29 · see citing works
Self-citationNanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery
Mustfa, S. A., Maurizi, E., McGrath, J. A., & Chiappini, C. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000160 · Cited by 28 · see citing works
Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery
Grande, F., Ioele, G., Occhiuzzi, M. A., Luca, M. D., Mazzotta, E., Ragno, G., Garofalo, A., & Muzzalupo, R. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050197 · Cited by 27 · see citing works
Nanotechnologies for early diagnosis, in situ disease monitoring, and prevention
Wu, T., Chiu, H., Yu, J., Cautela, M. P., Sarmento, B. F. C. C., das Neves, J., Catala, C., Pérez, N. P., Guerrini, L., Álvarez‐Puebla, R. A., et al. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-48063-5.00001-0 · Cited by 25 · see citing works
Self-citationBiodegradable Nanoparticles: A Recent Approach and Applications
Patil, V., & Patel, A. (2020) · Current Drug Targets · doi:10.2174/1389450121666200916091659 · Cited by 25 · see citing works
Campbell, G. R., Zhuang, J., Zhang, G., Landa, I., Kubiatowicz, L. J., Dehaini, D., Fang, R. H., Zhang, L., & Spector, S. A. (2021) · Theranostics · doi:10.7150/thno.59728 · Cited by 24 · see citing works
On-demand microbicide products: design matters
Patel, S. K., & Rohan, L. C. (2017) · Drug Delivery and Translational Research · doi:10.1007/s13346-017-0385-4 · Cited by 24 · see citing works
RETRACTED ARTICLE: LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs
Tian, W., Han, S., Huang, X., Han, M., Cao, J., Liang, Y., & Sun, Y. Y. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1596935 · Cited by 23 · see citing works
RetractedCervi, V. F., Saccol, C. P., Pinheiro, T. D. R., Santos, R. C. V., Sari, M. H. M., & Cruz, L. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01154-1 · Cited by 22 · see citing works
Szymańska, E., Wojasiński, M., Dąbrowska, J., Krzyżowska, M., Nowicka, M., Ciach, T., & Winnicka, K. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.207 · Cited by 21 · see citing works
Preclinical contraceptive development for men and women
Johnston, D. S., & Goldberg, E. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa076 · Cited by 21 · see citing works
Pharmaceutical Approaches to HIV Treatment and Prevention
Yavuz, B., Morgan, J. L., Showalter, L., Crakes, K. R., Dandekar, S., Herrera, C., LiWang, P. J., & Kaplan, D. L. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800054 · Cited by 21 · see citing works
Nanoformulations: A Valuable Tool in the Therapy of Viral Diseases Attacking Humans and Animals
Jampílek, J., & Kráľová, K. (2019) · Springer eBooks · doi:10.1007/978-3-030-29768-8_7 · Cited by 20 · see citing works
Fernandes, T., Baxi, K., Sawarkar, S. P., Sarmento, B. F. C. C., & das Neves, J. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1728251 · Cited by 20 · see citing works
Self-citationTargeted microbicides for preventing sexual HIV transmission
Coutinho, C., Sarmento, B. F. C. C., & das Neves, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.030 · Cited by 19 · see citing works
Self-citationKala, S., Watson, B. E., Zhang, J. G., Papp, E., Lenis, M. G., Dennehy, M. K., Cameron, D. W., Harrigan, P. R., & Serghides, L. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.09.008 · Cited by 19 · see citing works
Barreiros, L., Cunha-Reis, C., Silva, E. M. P., Carvalho, J. R. B., das Neves, J., Sarmento, B. F. C. C., & Segundo, M. A. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.12.028 · Cited by 16 · see citing works
Self-citationDahl, D. K., Whitesell, A. N., Sharma-Huynh, P., Maturavongsadit, P., Janusziewicz, R., Fox, R., Loznev, H. T., Button, B. M., Schorzman, A. N., Zamboni, W. C., et al. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121288 · Cited by 16 · see citing works
Antiretroviral drug-loaded nanoparticles-in-films: a new option for developing vaginal microbicides?
das Neves, J., & Sarmento, B. F. C. C. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2017.1270938 · Cited by 16 · see citing works
Self-citationVaginal Drug Delivery Systems to Control Microbe-Associated Infections
Xie, L., Li, Y., Liu, Y., Chai, Z., Ding, Y., Shi, L., & Wang, J. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00097 · Cited by 15 · see citing works
Lozoya-Agulló, I., Planelles, M., Merino‐Sanjuán, M., Bermejo, M., Sarmento, B. F. C. C., González‐Álvarez, I., & González‐Álvarez, M. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.12.038 · Cited by 15 · see citing works
Self-citationAdvanced Solid Formulations For Vulvovaginal Candidiasis
Conte, J., Parize, A. L., & Caon, T. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03441-5 · Cited by 14 · see citing works
Darwesh, A. Y., Helmy, A. M., Abdelhakk, H. M., Giri, B. R., & Maniruzzaman, M. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105775 · Cited by 14 · see citing works
Lipid Vesicles Loaded with an HIV-1 Fusion Inhibitor Peptide as a Potential Microbicide
Sánchez‐López, E., Paús, A., Pérez-Pomeda, I., Calpena, A. C., Haro, I., & Gomara, M. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060502 · Cited by 14 · see citing works
The vaginal sheet: an innovative form of vaginal film for the treatment of vaginal infections
Machado, R. M., Tomás, M., Palmeira‐de‐Oliveira, A., Martinez‐de‐Oliveira, J., & Palmeira‐de‐Oliveira, R. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2019.1711386 · Cited by 14 · see citing works
Delivery and short-term maternal and fetal safety of vaginally administered PEG-PLGA nanoparticles
Irvin-Choy, N. S., Nelson, K. M., Gleghorn, J. P., & Day, E. S. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01369-w · Cited by 13 · see citing works
Valle, M. J. D. J., Coutinho, P., Ribeiro, M. P., & Navarro, A. S. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.06.030 · Cited by 11 · see citing works
Nanotechnology for vaginal drug delivery and targeting
El‐Hammadi, M. M., & Arias, J. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102985-5.00026-7 · Cited by 12 · see citing works
Nanomedicine for Maternal and Fetal Health
Carter, D. M., Better, M., Abbasi, S., Zulfiqar, F., Shapiro, R. L., & Ensign, L. M. (2023) · Small · doi:10.1002/smll.202303682 · Cited by 12 · see citing works
Avlani, D., Shivakumar, H. N., Kumar, A., Prajila, A., Baraka, B. B. H., & Bhagya, V. R. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128816 · Cited by 11 · see citing works
Sims, L. B., Miller, H. A., Halwes, M. E., Steinbach-Rankins, J. M., & Frieboes, H. B. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.09.003 · Cited by 11 · see citing works
Szyk, P., Czarczyńska-Goślińska, B., Młynarczyk, D. T., Ślusarska, B. J., Kocki, T., Ziegler-Borowska, M., & Gośliński, T. A. (2023) · Nanomaterials · doi:10.3390/nano13192647 · Cited by 10 · see citing works
Nanoformulations for Vaginal Therapy
Vanić, Ž., & Škalko‐Basnet, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-70299-5_8 · Cited by 10 · see citing works
Biocompatible polyvinyl alcohol and RISUG ® blend polymeric films with spermicidal potential
Subramanian, B., Agarwal, T., Ghorai, S. K., Mandal, P., Chattopadhyay, S., Basak, P., Maiti, T. K., & Guha, S. K. (2019) · Biomedical Materials · doi:10.1088/1748-605x/ab04e1 · Cited by 10 · see citing works
Tong, X., Patel, S. K., Li, J., Patton, D. L., Xu, E., Anderson, P. L., Parikh, U. M., SWEENEY, Y. T. C., Strizki, J., Hillier, S. L., et al. (2022) · Polymers · doi:10.3390/polym14061196 · Cited by 9 · see citing works
Vaginal Formulations for Prevention of Sexual Transmission of HIV
Veiga-Ochoa, M. D., Ruíz, R., Cazorla-Luna, R., Martín-Illana, A., & Notario-Pérez, F. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.78314 · Cited by 8 · see citing works
Application of Nanotechnology in the Treatment of Infectious Diseases: An Overview
Mba, I. E., & Nweze, E. I. (2022) · Springer eBooks · doi:10.1007/978-981-16-9190-4_2 · Cited by 8 · see citing works
(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac134.315 · Cited by 7 · see citing works
Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges
Borenstein, J. T., Cummins, G., Dutta, A., Hamad, E. M., Hughes, M. P., Jiang, X., Lee, H., Lei, K. F., Tang, X. S., Zheng, Y., et al. (2023) · Lab on a Chip · doi:10.1039/d3lc00296a · Cited by 8 · see citing works
Bioadhesive Nanoparticles as Potent Drug Delivery Carriers
Rençber, S., Bülbül, E. Ö., Şenyiğit, Z. A., Okur, N. Ü., & Siafaka, P. I. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220613111635 · Cited by 6 · see citing works
Vaginal Bioadhesive Drug Delivery Systems and Their Applications
Deshkar, S. S., Shirolkar, S. V., & Patil, A. T. (2020) · doi:10.1002/9781119640240.ch11 · Cited by 6 · see citing works
Salmany, N., Lotfi, H., Keyhanmanesh, ., & Ghiasi, R. (2022) · Current Women s Health Reviews · doi:10.2174/1573404818666220427083700 · Cited by 5 · see citing works
Microbicides for Topical HIV Immunoprophylaxis: Current Status and Future Prospects
Zhernov, Y. V., Petrova, V. O., Simanduyev, M. Y., Shcherbakov, D. V., Полибин, Р. В., Mitrokhin, O. V., Basov, A. A., Zabroda, N. N., Высочанская, С. О., Al-khaleefa, E., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17060668 · Cited by 4 · see citing works
Kolawole, O. M., & Okeke, K. P. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106838 · Cited by 4 · see citing works
Pharmaceutical polymers in conventional dosage forms
Umeyor, C. E., Jadhav, S. A., Hanjankar, S. N., Nimkar, K. R., & Patravale, V. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95496-9.00005-3 · Cited by 5 · see citing works
Nanotechnology for Vaginal Drug Delivery and Targeting
El‐Hammadi, M. M., & Arias, J. L. (2016) · CRC Press eBooks · doi:10.1201/b19976-11 · Cited by 4 · see citing works
Hagesæther, E., Adamczak, M., Hiorth, M., & Tho, I. (2020) · doi:10.1002/9781119414018.ch5 · Cited by 4 · see citing works
Woerdenbag, H. J., Visser, J., Kauss, T., & Sznitowska, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-20298-8_19 · Cited by 3 · see citing works
Biotechnological Approaches in Infectious Diseases
Banerjee, S., Bose, S., Shukla, A. C., & Baig, M. R. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-1148-2_15 · Cited by 3 · see citing works
Kumar, A., Avlani, D., Murthy, S. N., Shivakumar, H. N., & Jindal, S. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2523991 · Cited by 3 · see citing works
Kumar, A., Shivakumar, H. N., Avlani, D., & Dhiman, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126262 · Cited by 2 · see citing works
Nanoparticle Encapsulation for Antiretroviral Pre-Exposure Prophylaxis
Shibata, A., Khandalavala, K., Mandal, S., Pham, R. N., & Destache, C. J. (2017) · Journal of Nanotechnology and Materials Science · doi:10.15436/2377-1372.17.1583 · Cited by 2 · see citing works
Controlled Drug Delivery via the Vaginal and Rectal Routes
das Neves, J., & Sarmento, B. F. C. C. (2021) · doi:10.1002/9781119769644.ch19 · Cited by 2 · see citing works
Self-citationPuvvada, N., Chandu, B., & Panigrahi, P. K. (2025) · Wiley eBooks · doi:10.1002/9781394200559.ch11 · Cited by 2 · see citing works
Novel Pharmaceutical Forms Including Biopolymer Encapsulated Antiviral Natural Compounds
Potuk, K., & Bayraktar, O. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-2843-5_10 · Cited by 1 · see citing works
Nanomicrobicides for HIV Vaginal Transmission prevention: Where do We stand?
Agrahari, V. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0033 · Cited by 1 · see citing works
A REVIEW ON BIOADHESIVE FILM FORMULATION FOR TREATMENT OF VAGINAL INFECTION
(2021) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2021/11.1.5817
A REVIEW ON BIOADHESIVE FILM FORMULATION FOR TREATMENT OF VAGINAL INFECTION
(2022) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2022/11.1.5817
Review of the current state of research in the field of film creation
Алексеев, К. В., Blynskaya, E. V., Буева, В. В., Тишков, С. В., Алексеев, В. К., Eremin, V. A., & Topilin, A. I. (2022) · doi:10.33920/med-13-2210-03
Programmable 3D printed conductive polymers for releasing neutrally-charged drugs
Alkahtani, M. E., Liu, Y., Li, H., Alfassam, H. A., Chapman, C. A. R., Green, R. A., Gaisford, S., Basit, A. W., Orlu, M., & Elbadawi, M. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100702
- Authors
- Cunha-Reis, C., Machado, A., Barreiros, L., Araújo, F., Nunes, R., Seabra, V., Ferreira, D., Segundo, M. A., Sarmento, B., & das Neves, J.
- Affiliations
- Cooperativa de Ensino Superior Politécnico e Universitário (PT)
- Universidade do Porto (PT)
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 243
- Pages
- 43-53
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2522640295
- Cited by
- 95
- References
- 76
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 15 · 2019: 10 · 2018: 14 · 2017: 10 · 2016: 3
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- FEDER
- Institute for Research and Innovation in Health Sciences (POCI-01-0145-FEDER-007274)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- vaginal drug delivery, tenofovir, efavirenz, PLGA nanoparticles, fast dissolving films, highly active antiretroviral therapy, vaginal histology
- MeSH terms
- Tenofovir, Polylactic Acid-Polyglycolic Acid Copolymer, Administration, Intravaginal, Alkynes, Animals, Chemistry, Pharmaceutical, Cyclopropanes, Drug Carriers, Drug Combinations, Female, Polyglycolic Acid, Tissue Distribution, Drug Delivery Systems, Lactic Acid, Anti-HIV Agents, Benzoxazines, Mice, Nanoparticles
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