Craniofacial variability and modularity in macaques and mice

Hallgrímsson, Benedikt; Willmore, Katherine; Dorval, Curtis; Cooper, David M.L.

doi:10.1002/jez.b.21002

Cited by 143Morphological variations and asymmetryCraniofacial Disorders and TreatmentsAnimal Behavior and Reproduction

Craniofacial variability and modularity in macaques and mice

Hallgrímsson, Benedikt, Willmore, Katherine, Dorval, Curtis, Cooper, David M.L.·2004·Journal of Experimental Zoology Part B Molecular and Developmental Evolution

DOI 10.1002/jez.b.21002

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Abstract

Evolutionary developmental biology of primates will be driven largely by the developmental biology of the house mouse. Inferences from how known developmental perturbations produce phenotypic effects in model organisms, such as mice, to how the same perturbations would affect craniofacial form in primates must be informed by comparisons of phenotypic variation and variability in mice and the primate species of interest. We use morphometric methods to compare patterns of cranial variability in homologous datasets obtained for two strains of laboratory mice and rhesus macaques. C57BL/6J represents a common genetic background for transgenic models. A/WySnJ mice exhibit altered facial morphology which results from reduction in the growth of the maxillary process during formation of the face. This is relevant to evolutionary changes in facial prognathism in nonhuman primate and human evolution. Rhesus macaques represent a nonhuman primate about which a great deal of phenotypic and genetic information is available. We find significant similarities in covariation patterns between the C57BL/6J mice and macaques. Among-trait variation in genetic and phenotypic variances are fairly concordant among the three groups, but among-trait variation in developmental stability is not. Finally, analysis of modularity based on phenotypic and genetic correlations did not reveal a consistent pattern in the three groups. We discuss the implications of these results for the study of evolutionary developmental biology of primates and outline a research strategy for integrating mouse genomics and developmental biology into this emerging field.

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Morphological integration is not absolute but organized in units that are relatively independent while participating to generate a structure that acts as a functional whole.
“Nonetheless, this integration is not absolute but organized in units that are relatively independent while participating to generate a structure that act as functional whole.”
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Authors: Hallgrímsson, B., Willmore, K., Dorval, C., & Cooper, D. M. L.
Affiliations: University of Calgary (CA)
Corresponding author: Hallgrímsson, Benedikt
ORCID: Hallgrímsson, Benedikt
Willmore, Katherine
Cooper, David M.L.
Venue: Journal of Experimental Zoology Part B Molecular and Developmental Evolution
Publisher: Wiley
Published: 2004-05-15
Volume: 302B
Issue: 3
Pages: 207-225
ISSN: 1552-5007 (ISSN-L)
1552-5015
DOI: 10.1002/jez.b.21002
OpenAlex: W2224335487
Cited by: 134
References: 74
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 10 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 4 · 2013: 6 · 2012: 7
FWCI: 11.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 31 d)
Locations: Journal of Experimental Zoology Part B Molecular and Developmental Evolution (publishedVersion)
PubMed (publishedVersion)
Funders: NSERC (238992-02)
CFI (3923)
Alberta Innovation and Science (URSI-01-103-RI to B.H.)
Topics: Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: modularity, skull morphology, rhesus monkeys, house mouse, C57BL/6J mice, maxillary process, developmental stability, covariation, evolutionary developmental biology
MeSH terms: Animals, Biometry, Body Weights and Measures, Bone Development, Biological Evolution, Macaca mulatta, Mice, Mutant Strains, Phenotype, Skull, Species Specificity, Principal Component Analysis, Mice

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Craniofacial variability and modularity in macaques and mice

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