The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
Open accessAbstract
ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory stimulation. Importantly, ICAM-1 serves as a biosensor to transduce outside-in-signaling via association of its cytoplasmic domain with the actin cytoskeleton following ligand engagement of the extracellular domain. Thus, ICAM-1 has emerged as a master regulator of many essential cellular functions both at the onset and at the resolution of pathologic conditions. Because the role of ICAM-1 in driving inflammatory responses is well recognized, this review will mainly focus on newly emerging roles of ICAM-1 in epithelial injury-resolution responses, as well as immune cell effector function in inflammation and tumorigenesis. ICAM-1 has been of clinical and therapeutic interest for some time now; however, several attempts at inhibiting its function to improve injury resolution have failed. Perhaps, better understanding of its beneficial roles in resolution of inflammation or its emerging function in tumorigenesis will spark new interest in revisiting the clinical value of ICAM-1 as a potential therapeutic target.
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Cited by
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Singh, V., Kaur, R., Kumari, P., Pasricha, C., & Singh, R. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117487 · Cited by 432
Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis
Młynarska, E., Bojdo, K., Frankenstein, H., Krawiranda, K., Kustosik, N., Lisińska, W., Rysz, J., & Franczyk, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010096 · Cited by 87
The link between neuroinflammation and the neurovascular unit in synucleinopathies
Wang, Q., Zheng, J., Pettersson, S., Reynolds, R., & Tan, E.-K. (2023) · Science Advances · doi:10.1126/sciadv.abq1141 · Cited by 81
Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease
Aili, M., Zhou, K., Zhan, J., Zheng, H., & Luo, F. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01023f · Cited by 80
Huang, Z., Merrihew, G. E., Larson, E. B., Park, J., Plubell, D., Fox, E. J., Montine, K. S., Latimer, C. S., Dirk Keene, C., Zou, J. Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38376-x · Cited by 37
Metadata
- Authors
- Bui, T. M., Wiesolek, H. L., & Sumagin, R.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-17
- Volume
- 108
- Issue
- 3
- Pages
- 787-799
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W3010838109
- Cited by
- 957
- References
- 8
- FWCI
- 52.88
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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