The inflammatory response in interleukin-1β-deficient mice: comparison with other cytokine-related knock-out mice.
Abstract
Interleukin-1 (IL-1) plays a crucial role in the development of the pathophysiological responses to infection and inflammation. However, the relative contributions of IL-1 alpha and IL-1 beta remain to be clarified. IL-1 beta-deficient mice are a powerful tool to investigate the specific role of IL-1 beta in various experimental conditions. In this report, we summarize the response of IL-1 beta deficient mice to two different inflammatory stimuli, turpentine and endotoxin. Although IL-1 beta-deficient mice respond normally to the systemic administration of lipopolysaccharide (LPS), they do not develop an acute-phase response in the localized tissue damage model of turpentine injection. The results obtained using the IL-1 beta-deficient mice are compared here with those observed in the IL-1 beta-converting enzyme-deficient, IL-6-deficient, tumour necrosis factor-receptor p55-deficient, and interferon-gamma-receptor-deficient mice.
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The relatively slow IL-6 response explains why corticosterone responses have previously been shown to be normal in IL-6-/- and IL-1-/- mice after TPS when evaluated at 1.5-2 h.
“The relatively slow IL-6 response explains why corticosterone responses have previously been shown to be normal in IL-6 Ϫ/Ϫ and IL-1 Ϫ/Ϫ mice after the injection of TPS, as corticosterone responses were evaluated at 1.5-2 h thereafter (20 -22) and is consistent with our finding that stressinduced corticosterone responses are similar in IL-6 ϩ/ϩ and IL-6 Ϫ/Ϫ mice.”
From Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice (2003) · cites this paper as [21]
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- Authors
- Fantuzzi, G., & Dinarello, C. A.
- Affiliations
- Tufts University (US)
- Corresponding author
- Dinarello, Charles A
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-04-01
- Volume
- 59
- Issue
- 4
- Pages
- 489-493
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2115587787
- Cited by
- 156
- References
- 32
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 7
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- IL-1β, inflammation, acute phase response, turpentine-induced inflammation, lipopolysaccharide, endotoxin, cytokine knockout mice, interleukin-6, TNF receptor p55, interferon-gamma receptor, tissue damage
- MeSH terms
- Animals, Humans, Inflammation, Interleukin-1, Lipopolysaccharides, Turpentine, Cytokines, Mice, Knockout, Mice
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