Cited by 156Immune Response and InflammationInflammasome and immune disordersInflammation biomarkers and pathways

The inflammatory response in interleukin-1β-deficient mice: comparison with other cytokine-related knock-out mice.

Fantuzzi, Giamila, Dinarello, Charles A·1996·Journal of Leukocyte Biology

Abstract

Interleukin-1 (IL-1) plays a crucial role in the development of the pathophysiological responses to infection and inflammation. However, the relative contributions of IL-1 alpha and IL-1 beta remain to be clarified. IL-1 beta-deficient mice are a powerful tool to investigate the specific role of IL-1 beta in various experimental conditions. In this report, we summarize the response of IL-1 beta deficient mice to two different inflammatory stimuli, turpentine and endotoxin. Although IL-1 beta-deficient mice respond normally to the systemic administration of lipopolysaccharide (LPS), they do not develop an acute-phase response in the localized tissue damage model of turpentine injection. The results obtained using the IL-1 beta-deficient mice are compared here with those observed in the IL-1 beta-converting enzyme-deficient, IL-6-deficient, tumour necrosis factor-receptor p55-deficient, and interferon-gamma-receptor-deficient mice.

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Crossref · 10.1002/jlb.59.4.489

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  • The relatively slow IL-6 response explains why corticosterone responses have previously been shown to be normal in IL-6-/- and IL-1-/- mice after TPS when evaluated at 1.5-2 h.

    “The relatively slow IL-6 response explains why corticosterone responses have previously been shown to be normal in IL-6 Ϫ/Ϫ and IL-1 Ϫ/Ϫ mice after the injection of TPS, as corticosterone responses were evaluated at 1.5-2 h thereafter (20 -22) and is consistent with our finding that stressinduced corticosterone responses are similar in IL-6 ϩ/ϩ and IL-6 Ϫ/Ϫ mice.”

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Authors
Fantuzzi, G., & Dinarello, C. A.
Affiliations
Tufts University (US)
Corresponding author
Dinarello, Charles A
Venue
Journal of Leukocyte Biology
Published
1996-04-01
Volume
59
Issue
4
Pages
489-493
ISSN
  • 0741-5400 (ISSN-L)
  • 1938-3673
OpenAlex
W2115587787
Cited by
156
References
32
Citations by year
2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 7
FWCI
5.07
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Leukocyte Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
IL-1β, inflammation, acute phase response, turpentine-induced inflammation, lipopolysaccharide, endotoxin, cytokine knockout mice, interleukin-6, TNF receptor p55, interferon-gamma receptor, tissue damage
MeSH terms
Animals, Humans, Inflammation, Interleukin-1, Lipopolysaccharides, Turpentine, Cytokines, Mice, Knockout, Mice

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