The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Quantification of liver iron with MRI: State of the art and remaining challenges
Open accessAbstract
Liver iron overload is the histological hallmark of hereditary hemochromatosis and transfusional hemosiderosis, and can also occur in chronic hepatopathies. Iron overload can result in liver damage, with the eventual development of cirrhosis, liver failure, and hepatocellular carcinoma. Assessment of liver iron levels is necessary for detection and quantitative staging of iron overload and monitoring of iron‐reducing treatments. This article discusses the need for noninvasive assessment of liver iron and reviews qualitative and quantitative methods with a particular emphasis on magnetic resonance imaging (MRI). Specific MRI methods for liver iron quantification include signal intensity ratio as well as R2 and R2* relaxometry techniques. Methods that are in clinical use, as well as their limitations, are described. Remaining challenges, unsolved problems, and emerging techniques to provide improved characterization of liver iron deposition are discussed. J. Magn. Reson. Imaging 2014;40:1003–1021. © 2014 Wiley Periodicals, Inc.
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Bravo, A. A., Sheth, S. G., & Chopra, S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440706 · Cited by 2,041
Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
Anderson, L. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2822 · Cited by 1,682
Szczepaniak, L. S., Nurenberg, P., Leonard, D., Browning, J. D., Reingold, J. S., Grundy, S., Hobbs, H. H., & Dobbins, R. L. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00064.2004 · Cited by 1,562
Schenck, J. F. (1996) · Medical Physics · doi:10.1118/1.597854 · Cited by 1,522
Theory of NMR signal behavior in magnetically inhomogeneous tissues: The static dephasing regime
Yablonskiy, D. A., & Haacke, E. M. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320610 · Cited by 1,198
Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis
Niederau, C., Fischer, R., Sonnenberg, A., Stremmel, W., Trampisch, H. J., & Strohmeyer, G. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511143132004 · Cited by 1,069
1H NMR chemical shift selective (CHESS) imaging
Haase, A., Frahm, J., Hanicke, W., & Matthaei, D. (1985) · Physics in Medicine and Biology · doi:10.1088/0031-9155/30/4/008 · Cited by 1,062
Wood, J. C., Enriquez, C., Ghugre, N., Tyzka, J. M., Carson, S., Nelson, M. D., & Coates, T. D. (2005) · Blood · doi:10.1182/blood-2004-10-3982 · Cited by 1,045
Hereditary Hemochromatosis — A New Look at an Old Disease
Pietrangelo, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031573 · Cited by 992
Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
St. Pierre, T. G., Clark, P. R., Chua-anusorn, W., Fleming, A. J., Jeffrey, G. P., Olynyk, J. K., Pootrakul, P., Robins, E., & Lindeman, R. (2005) · Blood · doi:10.1182/blood-2004-01-0177 · Cited by 909
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Ramanathan, R. K., Korn, R. L., Raghunand, N., Sachdev, J. C., Newbold, R. G., Jameson, G., Fetterly, G. J., Prey, J., Klinz, S. G., Kim, J., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1990 · Cited by 183
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Metadata
- Authors
- Hernando, D., Levin, Y. S., Sirlin, C. B., & Reeder, S. B.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2014-03-03
- Volume
- 40
- Issue
- 5
- Pages
- 1003-1021
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W1939928680
- Cited by
- 280
- References
- 101
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
