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Cited by 36Viral Infections and Immunology ResearchInfectious Encephalopathies and EncephalitisVirology and Viral Diseases

An aseptic meningitis outbreak caused by echovirus 6 in Anhui province, China

Mao, Naiying, Zhao, Liping, Zhu, Zhen, Chen, Xia, Zhou, Shujie, Zhang, Yan, Cui, Aili, Ji, Yixin +2 more·2010·Journal of Medical Virology
DOI 10.1002/jmv.21707
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Abstract

An outbreak of aseptic meningitis (AM) occurred in Jinzhai County in Anhui province from April to July in 2005. Totally, 97 children aged 3-15 years were hospitalized. To identify the etiologic agent, 77 cerebrospinal fluid specimens (CSF) and 5 fecal specimens were collected from the patients and cultured by human rhabdomyosarcoma (RD) cell line. Thirty isolates of human echovirus 6 (E6) from 27 CSF and 3 fecal specimens were confirmed by neutralization assay and sequencing analysis of the VP1 gene. The homology of VP1 gene among Anhui isolates was 99.7-100.0% and it indicated that this AM outbreak probable caused by a single transmission link of E6. Phylogenetic analysis based on all the available complete VP1 sequences indicated that E6 could be divided into clusters A, B, and C with at least 15% diversity between clusters and the C cluster could be further divided into C1, C2, C3, and C4. The Anhui isolates most resembled a 2005 strain from Russia (25465 Tambov) and belong to C4. This is the first report that E6 was responsible for an outbreak of AM in China. J. Med. Virol. 82:441-445, 2010. (c) 2010 Wiley-Liss, Inc.

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  • In China, several investigations on HEV associated aseptic meningitis outbreaks have been reported, including E30 in Jiangsu in 2003, E6 in Anhui in 2005, CVA9 in Gansu in 2005, and E30, CVB3 and CVB5 in Shandong in 2003, 2008 and 2009.

    “In China, several investigation on HEV associated aseptic meningitis outbreaks have been reported, such as echovirus (E) 30 in Jiangsu Province in 2003 [3], E6 in Anhui in 2005 [4], coxsackievirus (CV) A9 in Gansu in 2005 [5], E30, CVB3 and CVB5 in Shandong in 2003, 2008 and 2009, respectively [6]–[8].”

    From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [4]

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Authors
Mao, N., Zhao, L., Zhu, Z., Chen, X., Zhou, S., Zhang, Y., Cui, A., Ji, Y., Xu, S., & Xu, W.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • Anhui Provincial Center for Disease Control and Prevention (CN)
Corresponding author
Xu, WenBo
ORCID
Venue
Journal of Medical Virology
Publisher
Wiley
Published
2010-01-19
Volume
82
Issue
3
Pages
441-445
ISSN
  • 0146-6615 (ISSN-L)
  • 1096-9071
DOI
10.1002/jmv.21707
OpenAlex
W2029204218
Cited by
36
References
18
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
2.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Medical Virology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
aseptic meningitis, echovirus 6, viral outbreak, VP1 gene, phylogenetic analysis, children, Anhui Province, Jinzhai County, viral etiology
MeSH terms
Adolescent, Cell Line, Cerebrospinal Fluid, Child, Child, Preschool, China, Disease Outbreaks, Echovirus Infections, Echovirus 6, Human, Feces, Hospitalization, Humans, Meningitis, Aseptic, Molecular Sequence Data, Neutralization Tests, Phylogeny, Cluster Analysis, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Cell Culture Techniques, Capsid Proteins

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