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Cited by 68Viral Infections and Immunology ResearchInfectious Encephalopathies and EncephalitisVirology and Viral Diseases

Echovirus 30, Jiangsu Province, China

Open access
Zhao, Ya Nan, Jiang, Qing Wu, Jiang, Ren Jie, Chen, Liang, Perlin, David S.·2005·Emerging infectious diseases
DOI 10.3201/eid1104.040995PMC PMC3320326
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Abstract

An outbreak of aseptic meningitis occurred in the northern area of Jiangsu Province in China from January to July in 2003. A total of 1,681 cases were involved in this outbreak, and 99% of patients were <15 years of age. To identify the etiologic agent, 66 cerebrospinal fluid specimens were tested by cell culture. Eighteen showed an enteroviruslike cytopathic effect on MRC-5 human fetal diploid lung cells. An enterovirus primer-mediated reverse transcriptase-polymerase chain reaction, a standard neutralization assay, and sequencing of the complete capsid-encoding (VP1) gene identified the 18 isolates (FDJS03) as echovirus 30. At least a 10% difference was seen in nucleotide sequences of VP1 between FDJS03 isolates and other global strains of echovirus 30. Phylogenetic analysis based on complete sequences of VP1 was performed to further characterize the FDJS03 isolates. This report is the first to identify a distinct lineage of echovirus 30 as a probable cause of this outbreak.

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  • In China, documented E30 associated aseptic meningitis outbreaks occurred in Shandong and Jiangsu in 2003 and Fujian in 2011.

    “In China, the documented E30 associated aseptic meningitis outbreak occurred in the provinces of Shandong and Jiangsu in 2003 and Fujian in 2011 [3], [8], [35].”

    From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [3]

    The Abstract and Discussion report an E30-associated aseptic meningitis outbreak in Jiangsu Province in 2003. This paper does not document the outbreaks in Shandong in 2003 or Fujian in 2011 that are also included in the cited sentence. (LLM, conf=0.88)

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  • In China, several investigations on HEV associated aseptic meningitis outbreaks have been reported, including E30 in Jiangsu in 2003, E6 in Anhui in 2005, CVA9 in Gansu in 2005, and E30, CVB3 and CVB5 in Shandong in 2003, 2008 and 2009.

    “In China, several investigation on HEV associated aseptic meningitis outbreaks have been reported, such as echovirus (E) 30 in Jiangsu Province in 2003 [3], E6 in Anhui in 2005 [4], coxsackievirus (CV) A9 in Gansu in 2005 [5], E30, CVB3 and CVB5 in Shandong in 2003, 2008 and 2009, respectively [6]–[8].”

    From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [3]

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  1. [16]Hsiung GD. Picornaviridae. In: Hsiung GD, Fong CKY, Landry ML, editors. Hsiung's diagnostic virology, 4th ed. New Haven (CT): Yale University Press; 1994. p.119–40.

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Authors
Zhao, Y. N., Jiang, Q. W., Jiang, R. J., Chen, L., & Perlin, D. S.
Affiliations
  • Fudan University (CN)
  • Fudan University, Shanghai, China;
  • Yancheng Center for Disease Prevention and Control, Yancheng, China;
  • Public Health Research Institute, Newark, New Jersey, USA
ORCID
Venue
Emerging infectious diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Published
2005-04
Volume
11
Issue
4
Pages
562-567
ISSN
  • 1080-6040 (ISSN-L)
  • 1080-6059
DOI
10.3201/eid1104.040995
PMC
PMC3320326
OpenAlex
W2165094234
Cited by
68
References
32
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 11 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 5
FWCI
2.28
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Emerging infectious diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Government of Jiangsu Province
  • Ministry of Health of the People's Republic of China
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD041055)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
echovirus 30, aseptic meningitis, enterovirus outbreak, VP1 gene, phylogenetic analysis, nucleotide variation, Jiangsu Province, cerebrospinal fluid isolates
MeSH terms
Base Sequence, China, Disease Outbreaks, DNA, Viral, Echovirus Infections, Humans, Meningitis, Aseptic, Phylogeny, RNA, Viral, Enterovirus B, Human

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